A large and highly glycosylated protein constituent of LIPOPROTEIN (A). It has very little affinity for lipids but forms disulfide-linkage to APOLIPOPROTEIN B-100. Apoprotein(a) has SERINE PROTEINASE activity and can be of varying sizes from 400- to 800-kDa. It is homologous to PLASMINOGEN and is known to modulate THROMBOSIS and FIBRINOLYSIS.

Annotation

do not confuse with APOLIPOPROTEINS A, normal structural proteins of the alpha-lipoproteins (HIGH DENSITY LIPOPROTEINS)

DUI

D053241 MeSH Browser

CUI

M0001595

Previous indexing

Apolipoproteins (1977-1993); Apolipoproteins A (1982-2006); Apoproteins (1978-2004)

History note

2007 (1986); use APOLIPOPROTEINS A 1988-2006

Public note

2007; see APOLIPOPROTEINS A 1988-2006; APOLIPOPROTEIN LP(A+) was indexed under APOLIPOPROTEINS & LIPOPROTEIN(A) 1986-2006