Catechol O-Methyltransferase Inhibitors [inhibitory katechol-O-methyltransferasy]

topical
31
Terms

inhibitory COMT
inhibitory katechol-O-methyltransferázy
inhibitory katechol-O-metyltransferázy
katechol-O-methyltransferáza - inhibitory

Persistent link   https://www.medvik.cz/link/D065098
Definition

Compounds and drugs that inhibit or block the activity of CATECHOL O-METHYLTRANSFERASE enzymes. Drugs in this class are used in management of central nervous system disorders such as PARKINSON DISEASE.

DUI
D065098 MeSH Browser
CUI
M0587310
Previous indexing
Catechol O-Methyltransferase/ Antagonists & Inhibitors (1996-2014)
History note
2015
Public note
2015

Allowable subheadings

AD
administration & dosage
AE
adverse effects 1
AN
analysis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry 1
CL
classification 1
EC
economics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology 5
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use 7
TO
toxicity
UR
urine

D Chemicals and Drugs
D27 Chemical Actions and Uses 374
D27.505 Pharmacologic Actions 408
D27.505.519 Molecular Mechanisms of Pharmacological Action 89
D27.505.519.389 Enzyme Inhibitors 873
D27.505.519.389.086 5-Lipoxygenase-Activating Protein Inhibitors 3
D27.505.519.389.089 Acetaldehyde Dehydrogenase Inhibitors 2
D27.505.519.389.092 Adenosine Deaminase Inhibitors 6
D27.505.519.389.108 Adenylyl Cyclase Inhibitors 14
D27.505.519.389.124 Aromatic Amino Acid Decarboxylase Inhibitors 8
D27.505.519.389.174 Calcineurin Inhibitors 122
D27.505.519.389.200 Carbonic Anhydrase Inhibitors 59
D27.505.519.389.237 Catechol O-Methyltransferase Inhibitors 31
D27.505.519.389.275 Cholinesterase Inhibitors 967
D27.505.519.389.310 Cyclooxygenase Inhibitors 454
D27.505.519.389.315 Gamma Secretase Inhibitors and Modulators
D27.505.519.389.320 Glycoside Hydrolase Inhibitors 47
D27.505.519.389.335 Cytochrome P-450 Enzyme Inhibitors 93
D27.505.519.389.350 Folic Acid Antagonists 67
D27.505.519.389.360 Histone Deacetylase Inhibitors 110
D27.505.519.389.370 Hydroxymethylglutaryl-CoA Reductase Inhibitors 1 837
D27.505.519.389.375 Integrase Inhibitors 4
D27.505.519.389.400 beta-Lactamase Inhibitors 74
D27.505.519.389.480 Lipoxygenase Inhibitors 51
D27.505.519.389.616 Monoamine Oxidase Inhibitors 155
D27.505.519.389.675 Nucleic Acid Synthesis Inhibitors 33
D27.505.519.389.705 Ornithine Decarboxylase Inhibitors 3
D27.505.519.389.735 Phosphodiesterase Inhibitors 405
D27.505.519.389.736 Phosphoinositide-3 Kinase Inhibitors 31
D27.505.519.389.737 Phospholipase A2 Inhibitors 9
D27.505.519.389.739 Poly(ADP-ribose) Polymerase Inhibitors 185
D27.505.519.389.740 Prolyl-Hydroxylase Inhibitors 3
D27.505.519.389.745 Protease Inhibitors 272
D27.505.519.389.755 Protein Kinase Inhibitors 1 364
D27.505.519.389.760 Protein Synthesis Inhibitors 37
D27.505.519.389.848 Proton Pump Inhibitors 489
D27.505.519.389.870 Steroid Synthesis Inhibitors 1
D27.505.519.389.892 Topoisomerase Inhibitors 7
D27.505.519.389.936 Uncoupling Agents 24
D27.505.954 Therapeutic Uses 61
D27.505.954.427 Central Nervous System Agents 231
D27.505.954.427.090 Anti-Dyskinesia Agents 3
D27.505.954.427.090.050 Antiparkinson Agents 208
D27.505.954.427.090.050.249 Aromatic Amino Acid Decarboxylase Inhibitors 8
D27.505.954.427.090.050.500 Catechol O-Methyltransferase Inhibitors 31

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