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Pracoviště: Max Delbrück Center for Molecular Medicine in t...

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Individual Prognostication of Disease Activity and Disability Worsening in Multiple Sclerosis With Retinal Layer Thickness z Scores

Lin, Ting-Yi
Autor Lin, Ting-Yi ORCID From the Charité - Universitätsmedizin Berlin (T.-Y.L., S.M., S.A., C.C., S. Samadzadeh, J.B.-S., T.S.-H., A.U.B., H.G.Z., F.P.) Experimental and Clinical Research Center (T.-Y.L., S.M., S.A., C.C., S. Samadzadeh, J.B.-S., T.S.-H., A.U.B., H.G.Z., F.P.), a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité - Universitätsmedizin Berlin Max-Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) (T.-Y.L., S.M., S.A., C.C., S. Samadzadeh, J.B.-S., T.S.-H., A.U.B., H.G.Z., F.P.) Neuroscience Clinical Research Center (S.M., S.A., C.C., J.B.-S., T.S.-H., H.G.Z., F.P.) Department of Psychiatry and Psychotherapy (C.C.), Charité - Universitätsmedizin Berlin, Germany Department of Neurology (S. Saidha, P.A.C., K.C.F.) Department of Epidemiology (K.C.F.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD Department of Regional Health Research and Molecular Medicine (S. Samadzadeh), University of Southern Denmark, Odense Department of Neurology (S. Samadzadeh), Slagelse Hospital, Denmark Department of Neurology (P. Villoslada), Hospital Del Mar - Pompeu Fabra University Neuroimmunology and Multiple Sclerosis Unit (S.L.), Hospital Clinic Barcelona and IDIBAPS, Barcelona, Spain Department of Neurology (A.J.G.), University of California San Francisco Department of Neurology (J.L.P.), Charles University in Prague, Czech Republic Moorfield's Eye Hospital (A.P.), The National Hospital for Neurology and Neurosurgery, Queen Square Institute of Neurology, University College London, United Kingdom Neuro-ophthalmology Expert Center (A.P.), Amsterdam UMC, Netherlands Experimental Neurophysiology Unit (L.L.), Institute of Experimental Neurology (INSPE), San Raffaele Scientific Institute Vita-Salute San Raffaele University (L.L.), Milan, Italy Miguel Servet University Hospital (E.G.-M.), Zaragoza Department of Neurology (C.O.-G.), Hospital Clínico Universitario San Carlos, Madrid, Spain Department of Neurology (O.O., P. Vermersch) Department of Neuroradiology (O.O., P. Vermersch), Centre Hospitalier Universitaire de Lille, France Departments of Neurology (L.J.B., R.K.), Population Health and Ophthalmology, NYU Grossman School of Medicine, NY Department of Neurology (P.A., O.A.), Heinrich-Heine-University, Düsseldorf, Germany Departments of Clinical Neurosciences and Surgery Cumming School of Medicine (F.C.), University of Calgary, Alberta, Canada Clinic of Optic Neuritis and Clinic of Multiple Sclerosis (J.F.), Department of Neurology, Rigshospitalet - Glostrup, Denmark Department of Neurosciences (A.U., M.C.), Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Italy Laboratory of Neuroimmunology (E.M.F., T.C.F.), Professor Lawrence Steinman, Stanford University School of Medicine, Palo Alto, CA Department of Neurology (K.R., F.P.), Charité - Universitätsmedizin Berlin and Einstein Center Digital Future (H.G.Z.), Berlin, Germany
Motamedi, Seyedamirhosein
Autor Motamedi, Seyedamirhosein From the Charité - Universitätsmedizin Berlin (T.-Y.L., S.M., S.A., C.C., S. Samadzadeh, J.B.-S., T.S.-H., A.U.B., H.G.Z., F.P.) Experimental and Clinical Research Center (T.-Y.L., S.M., S.A., C.C., S. Samadzadeh, J.B.-S., T.S.-H., A.U.B., H.G.Z., F.P.), a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité - Universitätsmedizin Berlin Max-Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) (T.-Y.L., S.M., S.A., C.C., S. Samadzadeh, J.B.-S., T.S.-H., A.U.B., H.G.Z., F.P.) Neuroscience Clinical Research Center (S.M., S.A., C.C., J.B.-S., T.S.-H., H.G.Z., F.P.) Department of Psychiatry and Psychotherapy (C.C.), Charité - Universitätsmedizin Berlin, Germany Department of Neurology (S. Saidha, P.A.C., K.C.F.) Department of Epidemiology (K.C.F.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD Department of Regional Health Research and Molecular Medicine (S. Samadzadeh), University of Southern Denmark, Odense Department of Neurology (S. Samadzadeh), Slagelse Hospital, Denmark Department of Neurology (P. Villoslada), Hospital Del Mar - Pompeu Fabra University Neuroimmunology and Multiple Sclerosis Unit (S.L.), Hospital Clinic Barcelona and IDIBAPS, Barcelona, Spain Department of Neurology (A.J.G.), University of California San Francisco Department of Neurology (J.L.P.), Charles University in Prague, Czech Republic Moorfield's Eye Hospital (A.P.), The National Hospital for Neurology and Neurosurgery, Queen Square Institute of Neurology, University College London, United Kingdom Neuro-ophthalmology Expert Center (A.P.), Amsterdam UMC, Netherlands Experimental Neurophysiology Unit (L.L.), Institute of Experimental Neurology (INSPE), San Raffaele Scientific Institute Vita-Salute San Raffaele University (L.L.), Milan, Italy Miguel Servet University Hospital (E.G.-M.), Zaragoza Department of Neurology (C.O.-G.), Hospital Clínico Universitario San Carlos, Madrid, Spain Department of Neurology (O.O., P. Vermersch) Department of Neuroradiology (O.O., P. Vermersch), Centre Hospitalier Universitaire de Lille, France Departments of Neurology (L.J.B., R.K.), Population Health and Ophthalmology, NYU Grossman School of Medicine, NY Department of Neurology (P.A., O.A.), Heinrich-Heine-University, Düsseldorf, Germany Departments of Clinical Neurosciences and Surgery Cumming School of Medicine (F.C.), University of Calgary, Alberta, Canada Clinic of Optic Neuritis and Clinic of Multiple Sclerosis (J.F.), Department of Neurology, Rigshospitalet - Glostrup, Denmark Department of Neurosciences (A.U., M.C.), Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Italy Laboratory of Neuroimmunology (E.M.F., T.C.F.), Professor Lawrence Steinman, Stanford University School of Medicine, Palo Alto, CA Department of Neurology (K.R., F.P.), Charité - Universitätsmedizin Berlin and Einstein Center Digital Future (H.G.Z.), Berlin, Germany
Asseyer, Susanna
Autor Asseyer, Susanna From the Charité - Universitätsmedizin Berlin (T.-Y.L., S.M., S.A., C.C., S. Samadzadeh, J.B.-S., T.S.-H., A.U.B., H.G.Z., F.P.) Experimental and Clinical Research Center (T.-Y.L., S.M., S.A., C.C., S. Samadzadeh, J.B.-S., T.S.-H., A.U.B., H.G.Z., F.P.), a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité - Universitätsmedizin Berlin Max-Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) (T.-Y.L., S.M., S.A., C.C., S. Samadzadeh, J.B.-S., T.S.-H., A.U.B., H.G.Z., F.P.) Neuroscience Clinical Research Center (S.M., S.A., C.C., J.B.-S., T.S.-H., H.G.Z., F.P.) Department of Psychiatry and Psychotherapy (C.C.), Charité - Universitätsmedizin Berlin, Germany Department of Neurology (S. Saidha, P.A.C., K.C.F.) Department of Epidemiology (K.C.F.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD Department of Regional Health Research and Molecular Medicine (S. Samadzadeh), University of Southern Denmark, Odense Department of Neurology (S. Samadzadeh), Slagelse Hospital, Denmark Department of Neurology (P. Villoslada), Hospital Del Mar - Pompeu Fabra University Neuroimmunology and Multiple Sclerosis Unit (S.L.), Hospital Clinic Barcelona and IDIBAPS, Barcelona, Spain Department of Neurology (A.J.G.), University of California San Francisco Department of Neurology (J.L.P.), Charles University in Prague, Czech Republic Moorfield's Eye Hospital (A.P.), The National Hospital for Neurology and Neurosurgery, Queen Square Institute of Neurology, University College London, United Kingdom Neuro-ophthalmology Expert Center (A.P.), Amsterdam UMC, Netherlands Experimental Neurophysiology Unit (L.L.), Institute of Experimental Neurology (INSPE), San Raffaele Scientific Institute Vita-Salute San Raffaele University (L.L.), Milan, Italy Miguel Servet University Hospital (E.G.-M.), Zaragoza Department of Neurology (C.O.-G.), Hospital Clínico Universitario San Carlos, Madrid, Spain Department of Neurology (O.O., P. Vermersch) Department of Neuroradiology (O.O., P. Vermersch), Centre Hospitalier Universitaire de Lille, France Departments of Neurology (L.J.B., R.K.), Population Health and Ophthalmology, NYU Grossman School of Medicine, NY Department of Neurology (P.A., O.A.), Heinrich-Heine-University, Düsseldorf, Germany Departments of Clinical Neurosciences and Surgery Cumming School of Medicine (F.C.), University of Calgary, Alberta, Canada Clinic of Optic Neuritis and Clinic of Multiple Sclerosis (J.F.), Department of Neurology, Rigshospitalet - Glostrup, Denmark Department of Neurosciences (A.U., M.C.), Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Italy Laboratory of Neuroimmunology (E.M.F., T.C.F.), Professor Lawrence Steinman, Stanford University School of Medicine, Palo Alto, CA Department of Neurology (K.R., F.P.), Charité - Universitätsmedizin Berlin and Einstein Center Digital Future (H.G.Z.), Berlin, Germany
Chien, Claudia
Autor Chien, Claudia ORCID From the Charité - Universitätsmedizin Berlin (T.-Y.L., S.M., S.A., C.C., S. Samadzadeh, J.B.-S., T.S.-H., A.U.B., H.G.Z., F.P.) Experimental and Clinical Research Center (T.-Y.L., S.M., S.A., C.C., S. Samadzadeh, J.B.-S., T.S.-H., A.U.B., H.G.Z., F.P.), a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité - Universitätsmedizin Berlin Max-Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) (T.-Y.L., S.M., S.A., C.C., S. Samadzadeh, J.B.-S., T.S.-H., A.U.B., H.G.Z., F.P.) Neuroscience Clinical Research Center (S.M., S.A., C.C., J.B.-S., T.S.-H., H.G.Z., F.P.) Department of Psychiatry and Psychotherapy (C.C.), Charité - Universitätsmedizin Berlin, Germany Department of Neurology (S. Saidha, P.A.C., K.C.F.) Department of Epidemiology (K.C.F.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD Department of Regional Health Research and Molecular Medicine (S. Samadzadeh), University of Southern Denmark, Odense Department of Neurology (S. Samadzadeh), Slagelse Hospital, Denmark Department of Neurology (P. Villoslada), Hospital Del Mar - Pompeu Fabra University Neuroimmunology and Multiple Sclerosis Unit (S.L.), Hospital Clinic Barcelona and IDIBAPS, Barcelona, Spain Department of Neurology (A.J.G.), University of California San Francisco Department of Neurology (J.L.P.), Charles University in Prague, Czech Republic Moorfield's Eye Hospital (A.P.), The National Hospital for Neurology and Neurosurgery, Queen Square Institute of Neurology, University College London, United Kingdom Neuro-ophthalmology Expert Center (A.P.), Amsterdam UMC, Netherlands Experimental Neurophysiology Unit (L.L.), Institute of Experimental Neurology (INSPE), San Raffaele Scientific Institute Vita-Salute San Raffaele University (L.L.), Milan, Italy Miguel Servet University Hospital (E.G.-M.), Zaragoza Department of Neurology (C.O.-G.), Hospital Clínico Universitario San Carlos, Madrid, Spain Department of Neurology (O.O., P. Vermersch) Department of Neuroradiology (O.O., P. Vermersch), Centre Hospitalier Universitaire de Lille, France Departments of Neurology (L.J.B., R.K.), Population Health and Ophthalmology, NYU Grossman School of Medicine, NY Department of Neurology (P.A., O.A.), Heinrich-Heine-University, Düsseldorf, Germany Departments of Clinical Neurosciences and Surgery Cumming School of Medicine (F.C.), University of Calgary, Alberta, Canada Clinic of Optic Neuritis and Clinic of Multiple Sclerosis (J.F.), Department of Neurology, Rigshospitalet - Glostrup, Denmark Department of Neurosciences (A.U., M.C.), Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Italy Laboratory of Neuroimmunology (E.M.F., T.C.F.), Professor Lawrence Steinman, Stanford University School of Medicine, Palo Alto, CA Department of Neurology (K.R., F.P.), Charité - Universitätsmedizin Berlin and Einstein Center Digital Future (H.G.Z.), Berlin, Germany
Saidha, Shiv
Autor Saidha, Shiv ORCID From the Charité - Universitätsmedizin Berlin (T.-Y.L., S.M., S.A., C.C., S. Samadzadeh, J.B.-S., T.S.-H., A.U.B., H.G.Z., F.P.) Experimental and Clinical Research Center (T.-Y.L., S.M., S.A., C.C., S. Samadzadeh, J.B.-S., T.S.-H., A.U.B., H.G.Z., F.P.), a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité - Universitätsmedizin Berlin Max-Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) (T.-Y.L., S.M., S.A., C.C., S. Samadzadeh, J.B.-S., T.S.-H., A.U.B., H.G.Z., F.P.) Neuroscience Clinical Research Center (S.M., S.A., C.C., J.B.-S., T.S.-H., H.G.Z., F.P.) Department of Psychiatry and Psychotherapy (C.C.), Charité - Universitätsmedizin Berlin, Germany Department of Neurology (S. Saidha, P.A.C., K.C.F.) Department of Epidemiology (K.C.F.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD Department of Regional Health Research and Molecular Medicine (S. Samadzadeh), University of Southern Denmark, Odense Department of Neurology (S. Samadzadeh), Slagelse Hospital, Denmark Department of Neurology (P. Villoslada), Hospital Del Mar - Pompeu Fabra University Neuroimmunology and Multiple Sclerosis Unit (S.L.), Hospital Clinic Barcelona and IDIBAPS, Barcelona, Spain Department of Neurology (A.J.G.), University of California San Francisco Department of Neurology (J.L.P.), Charles University in Prague, Czech Republic Moorfield's Eye Hospital (A.P.), The National Hospital for Neurology and Neurosurgery, Queen Square Institute of Neurology, University College London, United Kingdom Neuro-ophthalmology Expert Center (A.P.), Amsterdam UMC, Netherlands Experimental Neurophysiology Unit (L.L.), Institute of Experimental Neurology (INSPE), San Raffaele Scientific Institute Vita-Salute San Raffaele University (L.L.), Milan, Italy Miguel Servet University Hospital (E.G.-M.), Zaragoza Department of Neurology (C.O.-G.), Hospital Clínico Universitario San Carlos, Madrid, Spain Department of Neurology (O.O., P. Vermersch) Department of Neuroradiology (O.O., P. Vermersch), Centre Hospitalier Universitaire de Lille, France Departments of Neurology (L.J.B., R.K.), Population Health and Ophthalmology, NYU Grossman School of Medicine, NY Department of Neurology (P.A., O.A.), Heinrich-Heine-University, Düsseldorf, Germany Departments of Clinical Neurosciences and Surgery Cumming School of Medicine (F.C.), University of Calgary, Alberta, Canada Clinic of Optic Neuritis and Clinic of Multiple Sclerosis (J.F.), Department of Neurology, Rigshospitalet - Glostrup, Denmark Department of Neurosciences (A.U., M.C.), Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Italy Laboratory of Neuroimmunology (E.M.F., T.C.F.), Professor Lawrence Steinman, Stanford University School of Medicine, Palo Alto, CA Department of Neurology (K.R., F.P.), Charité - Universitätsmedizin Berlin and Einstein Center Digital Future (H.G.Z.), Berlin, Germany
Calabresi, Peter A
Autor Calabresi, Peter A From the Charité - Universitätsmedizin Berlin (T.-Y.L., S.M., S.A., C.C., S. Samadzadeh, J.B.-S., T.S.-H., A.U.B., H.G.Z., F.P.) Experimental and Clinical Research Center (T.-Y.L., S.M., S.A., C.C., S. Samadzadeh, J.B.-S., T.S.-H., A.U.B., H.G.Z., F.P.), a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité - Universitätsmedizin Berlin Max-Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) (T.-Y.L., S.M., S.A., C.C., S. Samadzadeh, J.B.-S., T.S.-H., A.U.B., H.G.Z., F.P.) Neuroscience Clinical Research Center (S.M., S.A., C.C., J.B.-S., T.S.-H., H.G.Z., F.P.) Department of Psychiatry and Psychotherapy (C.C.), Charité - Universitätsmedizin Berlin, Germany Department of Neurology (S. Saidha, P.A.C., K.C.F.) Department of Epidemiology (K.C.F.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD Department of Regional Health Research and Molecular Medicine (S. Samadzadeh), University of Southern Denmark, Odense Department of Neurology (S. Samadzadeh), Slagelse Hospital, Denmark Department of Neurology (P. Villoslada), Hospital Del Mar - Pompeu Fabra University Neuroimmunology and Multiple Sclerosis Unit (S.L.), Hospital Clinic Barcelona and IDIBAPS, Barcelona, Spain Department of Neurology (A.J.G.), University of California San Francisco Department of Neurology (J.L.P.), Charles University in Prague, Czech Republic Moorfield's Eye Hospital (A.P.), The National Hospital for Neurology and Neurosurgery, Queen Square Institute of Neurology, University College London, United Kingdom Neuro-ophthalmology Expert Center (A.P.), Amsterdam UMC, Netherlands Experimental Neurophysiology Unit (L.L.), Institute of Experimental Neurology (INSPE), San Raffaele Scientific Institute Vita-Salute San Raffaele University (L.L.), Milan, Italy Miguel Servet University Hospital (E.G.-M.), Zaragoza Department of Neurology (C.O.-G.), Hospital Clínico Universitario San Carlos, Madrid, Spain Department of Neurology (O.O., P. Vermersch) Department of Neuroradiology (O.O., P. Vermersch), Centre Hospitalier Universitaire de Lille, France Departments of Neurology (L.J.B., R.K.), Population Health and Ophthalmology, NYU Grossman School of Medicine, NY Department of Neurology (P.A., O.A.), Heinrich-Heine-University, Düsseldorf, Germany Departments of Clinical Neurosciences and Surgery Cumming School of Medicine (F.C.), University of Calgary, Alberta, Canada Clinic of Optic Neuritis and Clinic of Multiple Sclerosis (J.F.), Department of Neurology, Rigshospitalet - Glostrup, Denmark Department of Neurosciences (A.U., M.C.), Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Italy Laboratory of Neuroimmunology (E.M.F., T.C.F.), Professor Lawrence Steinman, Stanford University School of Medicine, Palo Alto, CA Department of Neurology (K.R., F.P.), Charité - Universitätsmedizin Berlin and Einstein Center Digital Future (H.G.Z.), Berlin, Germany
Fitzgerald, Kathryn C
Autor Fitzgerald, Kathryn C ORCID From the Charité - Universitätsmedizin Berlin (T.-Y.L., S.M., S.A., C.C., S. Samadzadeh, J.B.-S., T.S.-H., A.U.B., H.G.Z., F.P.) Experimental and Clinical Research Center (T.-Y.L., S.M., S.A., C.C., S. Samadzadeh, J.B.-S., T.S.-H., A.U.B., H.G.Z., F.P.), a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité - Universitätsmedizin Berlin Max-Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) (T.-Y.L., S.M., S.A., C.C., S. Samadzadeh, J.B.-S., T.S.-H., A.U.B., H.G.Z., F.P.) Neuroscience Clinical Research Center (S.M., S.A., C.C., J.B.-S., T.S.-H., H.G.Z., F.P.) Department of Psychiatry and Psychotherapy (C.C.), Charité - Universitätsmedizin Berlin, Germany Department of Neurology (S. Saidha, P.A.C., K.C.F.) Department of Epidemiology (K.C.F.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD Department of Regional Health Research and Molecular Medicine (S. Samadzadeh), University of Southern Denmark, Odense Department of Neurology (S. Samadzadeh), Slagelse Hospital, Denmark Department of Neurology (P. Villoslada), Hospital Del Mar - Pompeu Fabra University Neuroimmunology and Multiple Sclerosis Unit (S.L.), Hospital Clinic Barcelona and IDIBAPS, Barcelona, Spain Department of Neurology (A.J.G.), University of California San Francisco Department of Neurology (J.L.P.), Charles University in Prague, Czech Republic Moorfield's Eye Hospital (A.P.), The National Hospital for Neurology and Neurosurgery, Queen Square Institute of Neurology, University College London, United Kingdom Neuro-ophthalmology Expert Center (A.P.), Amsterdam UMC, Netherlands Experimental Neurophysiology Unit (L.L.), Institute of Experimental Neurology (INSPE), San Raffaele Scientific Institute Vita-Salute San Raffaele University (L.L.), Milan, Italy Miguel Servet University Hospital (E.G.-M.), Zaragoza Department of Neurology (C.O.-G.), Hospital Clínico Universitario San Carlos, Madrid, Spain Department of Neurology (O.O., P. Vermersch) Department of Neuroradiology (O.O., P. Vermersch), Centre Hospitalier Universitaire de Lille, France Departments of Neurology (L.J.B., R.K.), Population Health and Ophthalmology, NYU Grossman School of Medicine, NY Department of Neurology (P.A., O.A.), Heinrich-Heine-University, Düsseldorf, Germany Departments of Clinical Neurosciences and Surgery Cumming School of Medicine (F.C.), University of Calgary, Alberta, Canada Clinic of Optic Neuritis and Clinic of Multiple Sclerosis (J.F.), Department of Neurology, Rigshospitalet - Glostrup, Denmark Department of Neurosciences (A.U., M.C.), Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Italy Laboratory of Neuroimmunology (E.M.F., T.C.F.), Professor Lawrence Steinman, Stanford University School of Medicine, Palo Alto, CA Department of Neurology (K.R., F.P.), Charité - Universitätsmedizin Berlin and Einstein Center Digital Future (H.G.Z.), Berlin, Germany
Samadzadeh, Sara
Autor Samadzadeh, Sara From the Charité - Universitätsmedizin Berlin (T.-Y.L., S.M., S.A., C.C., S. Samadzadeh, J.B.-S., T.S.-H., A.U.B., H.G.Z., F.P.) Experimental and Clinical Research Center (T.-Y.L., S.M., S.A., C.C., S. Samadzadeh, J.B.-S., T.S.-H., A.U.B., H.G.Z., F.P.), a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité - Universitätsmedizin Berlin Max-Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) (T.-Y.L., S.M., S.A., C.C., S. Samadzadeh, J.B.-S., T.S.-H., A.U.B., H.G.Z., F.P.) Neuroscience Clinical Research Center (S.M., S.A., C.C., J.B.-S., T.S.-H., H.G.Z., F.P.) Department of Psychiatry and Psychotherapy (C.C.), Charité - Universitätsmedizin Berlin, Germany Department of Neurology (S. Saidha, P.A.C., K.C.F.) Department of Epidemiology (K.C.F.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD Department of Regional Health Research and Molecular Medicine (S. Samadzadeh), University of Southern Denmark, Odense Department of Neurology (S. Samadzadeh), Slagelse Hospital, Denmark Department of Neurology (P. Villoslada), Hospital Del Mar - Pompeu Fabra University Neuroimmunology and Multiple Sclerosis Unit (S.L.), Hospital Clinic Barcelona and IDIBAPS, Barcelona, Spain Department of Neurology (A.J.G.), University of California San Francisco Department of Neurology (J.L.P.), Charles University in Prague, Czech Republic Moorfield's Eye Hospital (A.P.), The National Hospital for Neurology and Neurosurgery, Queen Square Institute of Neurology, University College London, United Kingdom Neuro-ophthalmology Expert Center (A.P.), Amsterdam UMC, Netherlands Experimental Neurophysiology Unit (L.L.), Institute of Experimental Neurology (INSPE), San Raffaele Scientific Institute Vita-Salute San Raffaele University (L.L.), Milan, Italy Miguel Servet University Hospital (E.G.-M.), Zaragoza Department of Neurology (C.O.-G.), Hospital Clínico Universitario San Carlos, Madrid, Spain Department of Neurology (O.O., P. Vermersch) Department of Neuroradiology (O.O., P. Vermersch), Centre Hospitalier Universitaire de Lille, France Departments of Neurology (L.J.B., R.K.), Population Health and Ophthalmology, NYU Grossman School of Medicine, NY Department of Neurology (P.A., O.A.), Heinrich-Heine-University, Düsseldorf, Germany Departments of Clinical Neurosciences and Surgery Cumming School of Medicine (F.C.), University of Calgary, Alberta, Canada Clinic of Optic Neuritis and Clinic of Multiple Sclerosis (J.F.), Department of Neurology, Rigshospitalet - Glostrup, Denmark Department of Neurosciences (A.U., M.C.), Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Italy Laboratory of Neuroimmunology (E.M.F., T.C.F.), Professor Lawrence Steinman, Stanford University School of Medicine, Palo Alto, CA Department of Neurology (K.R., F.P.), Charité - Universitätsmedizin Berlin and Einstein Center Digital Future (H.G.Z.), Berlin, Germany
Villoslada, Pablo
Autor Villoslada, Pablo ORCID From the Charité - Universitätsmedizin Berlin (T.-Y.L., S.M., S.A., C.C., S. Samadzadeh, J.B.-S., T.S.-H., A.U.B., H.G.Z., F.P.) Experimental and Clinical Research Center (T.-Y.L., S.M., S.A., C.C., S. Samadzadeh, J.B.-S., T.S.-H., A.U.B., H.G.Z., F.P.), a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité - Universitätsmedizin Berlin Max-Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) (T.-Y.L., S.M., S.A., C.C., S. Samadzadeh, J.B.-S., T.S.-H., A.U.B., H.G.Z., F.P.) Neuroscience Clinical Research Center (S.M., S.A., C.C., J.B.-S., T.S.-H., H.G.Z., F.P.) Department of Psychiatry and Psychotherapy (C.C.), Charité - Universitätsmedizin Berlin, Germany Department of Neurology (S. Saidha, P.A.C., K.C.F.) Department of Epidemiology (K.C.F.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD Department of Regional Health Research and Molecular Medicine (S. Samadzadeh), University of Southern Denmark, Odense Department of Neurology (S. Samadzadeh), Slagelse Hospital, Denmark Department of Neurology (P. Villoslada), Hospital Del Mar - Pompeu Fabra University Neuroimmunology and Multiple Sclerosis Unit (S.L.), Hospital Clinic Barcelona and IDIBAPS, Barcelona, Spain Department of Neurology (A.J.G.), University of California San Francisco Department of Neurology (J.L.P.), Charles University in Prague, Czech Republic Moorfield's Eye Hospital (A.P.), The National Hospital for Neurology and Neurosurgery, Queen Square Institute of Neurology, University College London, United Kingdom Neuro-ophthalmology Expert Center (A.P.), Amsterdam UMC, Netherlands Experimental Neurophysiology Unit (L.L.), Institute of Experimental Neurology (INSPE), San Raffaele Scientific Institute Vita-Salute San Raffaele University (L.L.), Milan, Italy Miguel Servet University Hospital (E.G.-M.), Zaragoza Department of Neurology (C.O.-G.), Hospital Clínico Universitario San Carlos, Madrid, Spain Department of Neurology (O.O., P. Vermersch) Department of Neuroradiology (O.O., P. Vermersch), Centre Hospitalier Universitaire de Lille, France Departments of Neurology (L.J.B., R.K.), Population Health and Ophthalmology, NYU Grossman School of Medicine, NY Department of Neurology (P.A., O.A.), Heinrich-Heine-University, Düsseldorf, Germany Departments of Clinical Neurosciences and Surgery Cumming School of Medicine (F.C.), University of Calgary, Alberta, Canada Clinic of Optic Neuritis and Clinic of Multiple Sclerosis (J.F.), Department of Neurology, Rigshospitalet - Glostrup, Denmark Department of Neurosciences (A.U., M.C.), Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Italy Laboratory of Neuroimmunology (E.M.F., T.C.F.), Professor Lawrence Steinman, Stanford University School of Medicine, Palo Alto, CA Department of Neurology (K.R., F.P.), Charité - Universitätsmedizin Berlin and Einstein Center Digital Future (H.G.Z.), Berlin, Germany
Llufriu, Sara
Autor Llufriu, Sara ORCID From the Charité - Universitätsmedizin Berlin (T.-Y.L., S.M., S.A., C.C., S. Samadzadeh, J.B.-S., T.S.-H., A.U.B., H.G.Z., F.P.) Experimental and Clinical Research Center (T.-Y.L., S.M., S.A., C.C., S. Samadzadeh, J.B.-S., T.S.-H., A.U.B., H.G.Z., F.P.), a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité - Universitätsmedizin Berlin Max-Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) (T.-Y.L., S.M., S.A., C.C., S. Samadzadeh, J.B.-S., T.S.-H., A.U.B., H.G.Z., F.P.) Neuroscience Clinical Research Center (S.M., S.A., C.C., J.B.-S., T.S.-H., H.G.Z., F.P.) Department of Psychiatry and Psychotherapy (C.C.), Charité - Universitätsmedizin Berlin, Germany Department of Neurology (S. Saidha, P.A.C., K.C.F.) Department of Epidemiology (K.C.F.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD Department of Regional Health Research and Molecular Medicine (S. Samadzadeh), University of Southern Denmark, Odense Department of Neurology (S. Samadzadeh), Slagelse Hospital, Denmark Department of Neurology (P. Villoslada), Hospital Del Mar - Pompeu Fabra University Neuroimmunology and Multiple Sclerosis Unit (S.L.), Hospital Clinic Barcelona and IDIBAPS, Barcelona, Spain Department of Neurology (A.J.G.), University of California San Francisco Department of Neurology (J.L.P.), Charles University in Prague, Czech Republic Moorfield's Eye Hospital (A.P.), The National Hospital for Neurology and Neurosurgery, Queen Square Institute of Neurology, University College London, United Kingdom Neuro-ophthalmology Expert Center (A.P.), Amsterdam UMC, Netherlands Experimental Neurophysiology Unit (L.L.), Institute of Experimental Neurology (INSPE), San Raffaele Scientific Institute Vita-Salute San Raffaele University (L.L.), Milan, Italy Miguel Servet University Hospital (E.G.-M.), Zaragoza Department of Neurology (C.O.-G.), Hospital Clínico Universitario San Carlos, Madrid, Spain Department of Neurology (O.O., P. Vermersch) Department of Neuroradiology (O.O., P. Vermersch), Centre Hospitalier Universitaire de Lille, France Departments of Neurology (L.J.B., R.K.), Population Health and Ophthalmology, NYU Grossman School of Medicine, NY Department of Neurology (P.A., O.A.), Heinrich-Heine-University, Düsseldorf, Germany Departments of Clinical Neurosciences and Surgery Cumming School of Medicine (F.C.), University of Calgary, Alberta, Canada Clinic of Optic Neuritis and Clinic of Multiple Sclerosis (J.F.), Department of Neurology, Rigshospitalet - Glostrup, Denmark Department of Neurosciences (A.U., M.C.), Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Italy Laboratory of Neuroimmunology (E.M.F., T.C.F.), Professor Lawrence Steinman, Stanford University School of Medicine, Palo Alto, CA Department of Neurology (K.R., F.P.), Charité - Universitätsmedizin Berlin and Einstein Center Digital Future (H.G.Z.), Berlin, Germany

Neurology® neuroimmunology & neuroinflammation. 2024 ; 11 (5) : e200269. [pub] 20240628

Neurol Neuroimmunol Neuroinflamm
ISSN 2332-7812
Medvik
Zdroj

BACKGROUND AND OBJECTIVES: Retinal optical coherence tomography (OCT) provides promising prognostic imaging biomarkers for future disease activity in multiple sclerosis (MS). However, raw OCT-derived measures have multiple dependencies, supporting the need for establishing reference values adjusted for possible confounders. The purpose of this study was to investigate the capacity for age-adjusted z scores of OCT-derived measures to prognosticate future disease activity and disability worsening in people with MS (PwMS). METHODS: We established age-adjusted OCT reference data using generalized additive models for location, scale, and shape for peripapillary retinal nerve fiber layer (pRNFL) and ganglion cell-inner plexiform layer (GCIP) thicknesses, involving 910 and 423 healthy eyes, respectively. Next, we transformed the retinal layer thickness of PwMS from 3 published studies into age-adjusted z scores (pRNFL-z and GCIP-z) based on the reference data. Finally, we investigated the association of pRNFL-z or GCIP-z as predictors with future confirmed disability worsening (Expanded Disability Status Scale score increase) or disease activity (failing of the no evidence of disease activity [NEDA-3] criteria) as outcomes. Cox proportional hazards models or logistic regression analyses were applied according to the original studies. Optimal cutoffs were identified using the Akaike information criterion as well as location with the log-rank and likelihood-ratio tests. RESULTS: In the first cohort (n = 863), 172 PwMS (24%) had disability worsening over a median observational period of 2.0 (interquartile range [IQR]:1.0-3.0) years. Low pRNFL-z (≤-2.04) were associated with an increased risk of disability worsening (adjusted hazard ratio (aHR) [95% CI] = 2.08 [1.47-2.95], p = 3.82e-5). In the second cohort (n = 170), logistic regression analyses revealed that lower pRNFL-z showed a higher likelihood for disability accumulation at the two-year follow-up (reciprocal odds ratio [95% CI] = 1.51[1.06-2.15], p = 0.03). In the third cohort (n = 78), 46 PwMS (59%) did not maintain the NEDA-3 status over a median follow-up of 2.0 (IQR: 1.9-2.1) years. PwMS with low GCIP-z (≤-1.03) had a higher risk of showing disease activity (aHR [95% CI] = 2.14 [1.03-4.43], p = 0.04). Compared with raw values with arbitrary cutoffs, applying the z score approach with optimal cutoffs showed better performance in discrimination and calibration (higher Harrell's concordance index and lower integrated Brier score). DISCUSSION: In conclusion, our work demonstrated reference cohort-based z scores that account for age, a major driver for disease progression in MS, to be a promising approach for creating OCT-derived measures useable across devices and toward individualized prognostication.

MeSH
dospělí MeSH
lidé středního věku MeSH
lidé MeSH
optická koherentní tomografie * MeSH
prognóza MeSH
progrese nemoci * MeSH
retina diagnostické zobrazování patologie patofyziologie MeSH
roztroušená skleróza * patofyziologie diagnostické zobrazování MeSH
stupeň závažnosti nemoci MeSH
Check Tag
dospělí MeSH
lidé středního věku MeSH
lidé MeSH
mužské pohlaví MeSH
ženské pohlaví MeSH
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časopisecké články MeSH

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