Toxin-antitoxin systems (TAS) emerged more than 25 years ago and developed as an important field in molecular microbiology. TAS are autoregulated operons coding a stable toxin and an unstable antitoxin found in plasmids and chromosomes of Bacteria and Archaea. The conditional activation of their toxins interferes with cell growth/viability and, depending on the context, can influence plasmid maintenance, stress management, bacterial persistence, cell differentiation and, likely, bacterial virulence. This review summarizes recent results on the parD system of plasmid R1 and on the chromosomal relBE systems found in Escherichia coli and in Streptococcus pneumoniae with a focus on the RNase activity of their toxins, their regulation and their biomedical applications and implications.
- MeSH
- antitoxiny genetika imunologie metabolismus MeSH
- bakteriální toxiny genetika imunologie metabolismus MeSH
- biotechnologie metody trendy MeSH
- buňky - růstové procesy genetika imunologie MeSH
- financování organizované MeSH
- inhibitory syntézy proteinů imunologie metabolismus MeSH
- lidé MeSH
- mikrobiologie trendy MeSH
- molekulární biologie metody trendy MeSH
- plazmidy genetika MeSH
- ribonukleasy genetika imunologie toxicita MeSH
- ribozomy genetika imunologie MeSH
- RNA genetika imunologie toxicita MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- přehledy MeSH
