Species of Scedosporium and Lomentospora are considered as emerging opportunists, affecting immunosuppressed and otherwise debilitated patients, although classically they are known from causing trauma-associated infections in healthy individuals. Clinical manifestations range from local infection to pulmonary colonization and severe invasive disease, in which mortality rates may be over 80%. These unacceptably high rates are due to the clinical status of patients, diagnostic difficulties, and to intrinsic antifungal resistance of these fungi. In consequence, several consortia have been founded to increase research efforts on these orphan fungi. The current review presents recent findings and summarizes the most relevant points, including the Scedosporium/Lomentospora taxonomy, environmental distribution, epidemiology, pathology, virulence factors, immunology, diagnostic methods, and therapeutic strategies.
- MeSH
- antifungální látky farmakologie terapeutické užití MeSH
- Ascomycota klasifikace účinky léků genetika fyziologie MeSH
- chirurgie operační MeSH
- ekologie MeSH
- faktory virulence MeSH
- hostitel s imunodeficiencí MeSH
- interakce hostitele a patogenu imunologie MeSH
- kombinovaná terapie MeSH
- lidé MeSH
- mnohočetná fungální léková rezistence genetika MeSH
- molekulární typizace MeSH
- mykózy diagnóza mikrobiologie patologie terapie MeSH
- oportunní infekce diagnóza mikrobiologie patologie terapie MeSH
- Scedosporium klasifikace účinky léků genetika fyziologie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
