Background: Low back pain (LBP) is one of the common musckloskeletal diseases and usual treated by epidural steroid injection (ESI). ESIs improve patients' quality of life, reduce lumbar radicular pain, and postpone spinal surgery. The mechanism of improvement is yet unscertain, perhaps involve type α collagen (COL2α) for bone maintenance, hence, we sought to investigate the role of injected steroids in bone healing focusing on the role of COL2α.Methods: All patients in this research were diagnosed by specialists based on their histories and clinical features and associated diseaeses or compiling therapy. Serum samples collected from LBP patients and control group for comparisons.Results: The present study found a significant (<0.0001) increase in the concentration of COL2α in patients with LBP after injection with ESI treatment compared with patients before injection and healthy individuals.Conclusion: ESI helps LBP sufferers by boosting COL2α, which repairs damaged tissues.
- MeSH
- biologické markery analýza MeSH
- bolesti zad * farmakoterapie MeSH
- glukokortikoidy aplikace a dávkování farmakologie terapeutické užití MeSH
- injekce epidurální * metody MeSH
- klinická studie jako téma metody MeSH
- kolagen typ II * aplikace a dávkování farmakologie terapeutické užití MeSH
- lidé MeSH
- management bolesti metody MeSH
- radikulopatie etiologie farmakoterapie MeSH
- regenerace kostí účinky léků MeSH
- Check Tag
- lidé MeSH
