The recent SARS-CoV-2 pandemic has refocused attention to the betacoronaviruses, only eight years after the emergence of another zoonotic betacoronavirus, the Middle East respiratory syndrome coronavirus (MERS-CoV). While the wild source of SARS-CoV-2 may be disputed, for MERS-CoV, dromedaries are considered as source of zoonotic human infections. Testing 100 immune-response genes in 121 dromedaries from United Arab Emirates (UAE) for potential association with present MERS-CoV infection, we identified candidate genes with important functions in the adaptive, MHC-class I (HLA-A-24-like) and II (HLA-DPB1-like), and innate immune response (PTPN4, MAGOHB), and in cilia coating the respiratory tract (DNAH7). Some of these genes previously have been associated with viral replication in SARS-CoV-1/-2 in humans, others have an important role in the movement of bronchial cilia. These results suggest similar host genetic pathways associated with these betacoronaviruses, although further work is required to better understand the MERS-CoV disease dynamics in both dromedaries and humans.
- MeSH
- adaptivní imunita genetika MeSH
- bronchy cytologie fyziologie MeSH
- cilie fyziologie MeSH
- COVID-19 genetika imunologie virologie MeSH
- genetická predispozice k nemoci MeSH
- interakce mikroorganismu a hostitele genetika imunologie MeSH
- koronavirové infekce genetika imunologie přenos virologie MeSH
- koronavirus MERS imunologie izolace a purifikace patogenita MeSH
- lidé MeSH
- objevující se infekční nemoci genetika imunologie přenos virologie MeSH
- přirozená imunita genetika MeSH
- protilátky virové MeSH
- replikace viru genetika imunologie MeSH
- respirační sliznice cytologie fyziologie MeSH
- SARS-CoV-2 imunologie patogenita MeSH
- velbloudi genetika imunologie virologie MeSH
- zdroje nemoci virologie MeSH
- zoonózy genetika imunologie přenos virologie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Spojené arabské emiráty MeSH
