Several new biocompatible and degradable materials were prepared by chemical modification of sodium hyaluronate. The method of activation of hyaluronate by cyanogen bromide was used and subsequent reaction with nucleophile led to the formation of carbamate. This modification of hydroxyl groups of glycosaminoglycans preserves the carboxyl groups and retains properties of polyelectrolyte. This method affords derivatives easily and the reaction condition correlates with degree of substitution. The experimental results show the effect of reaction conditions (reaction time, ratio of reactants) and effect of substitution on biodegradability. The obtained materials were characterized by nuclear magnetic resonance and Fourier transform infrared spectroscopy. Copyright (c) 2006 Wiley Periodicals, Inc.

• MeSH
• biodegradace MeSH
• biokompatibilní materiály chemická syntéza   MeSH
• bromkyan chemie   MeSH
• financování organizované MeSH
• gelová chromatografie MeSH
• glykosaminoglykany chemie   MeSH
• hyaluronoglukosaminidasa farmakologie   MeSH
• hydroxylový radikál chemie   MeSH
• karbamáty chemická syntéza   MeSH
• kinetika MeSH
• kyselina hyaluronová chemická syntéza   chemie   MeSH
• nukleární magnetická rezonance biomolekulární MeSH
• rozpustnost MeSH
• skot MeSH
• spektroskopie infračervená s Fourierovou transformací MeSH
• viskozita MeSH
• voda chemie   MeSH
• zvířata MeSH
• Check Tag
• mužské pohlaví MeSH
• skot MeSH
• zvířata MeSH