-
Je něco špatně v tomto záznamu ?
Synthesis and characterization of new biodegradable hyaluronan alkyl derivatives
Mlcochová P, Bystrický S, Steiner B, Machová E, Koós M, Velebný V, Krcmár M.
Jazyk angličtina Země Spojené státy americké
NLK
Wiley Online Library (archiv)
od 1996-01-01 do 2012-12-31
Wiley Online Library (archiv)
od 1996-01-01 do 2012-12-31
- MeSH
- biodegradace MeSH
- biokompatibilní materiály chemická syntéza MeSH
- bromkyan chemie MeSH
- financování organizované MeSH
- gelová chromatografie MeSH
- glykosaminoglykany chemie MeSH
- hyaluronoglukosaminidasa farmakologie MeSH
- hydroxylový radikál chemie MeSH
- karbamáty chemická syntéza MeSH
- kinetika MeSH
- kyselina hyaluronová chemická syntéza chemie MeSH
- nukleární magnetická rezonance biomolekulární MeSH
- rozpustnost MeSH
- skot MeSH
- spektroskopie infračervená s Fourierovou transformací MeSH
- viskozita MeSH
- voda chemie MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- skot MeSH
- zvířata MeSH
Several new biocompatible and degradable materials were prepared by chemical modification of sodium hyaluronate. The method of activation of hyaluronate by cyanogen bromide was used and subsequent reaction with nucleophile led to the formation of carbamate. This modification of hydroxyl groups of glycosaminoglycans preserves the carboxyl groups and retains properties of polyelectrolyte. This method affords derivatives easily and the reaction condition correlates with degree of substitution. The experimental results show the effect of reaction conditions (reaction time, ratio of reactants) and effect of substitution on biodegradability. The obtained materials were characterized by nuclear magnetic resonance and Fourier transform infrared spectroscopy. Copyright (c) 2006 Wiley Periodicals, Inc.
- 000
- 00000naa 2200000 a 4500
- 001
- bmc07521407
- 003
- CZ-PrNML
- 005
- 20240918124022.0
- 008
- 090422s2006 xxu e eng||
- 009
- AR
- 040 __
- $a ABA008 $b cze $c ABA008 $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxu
- 100 1_
- $a Mlčochová, Petra $7 _AN030986
- 245 10
- $a Synthesis and characterization of new biodegradable hyaluronan alkyl derivatives / $c Mlcochová P, Bystrický S, Steiner B, Machová E, Koós M, Velebný V, Krcmár M.
- 314 __
- $a CPN spol. s r.o., Dolní Dobrouc, Czech Republic. mlcochova@contipro.cz
- 520 9_
- $a Several new biocompatible and degradable materials were prepared by chemical modification of sodium hyaluronate. The method of activation of hyaluronate by cyanogen bromide was used and subsequent reaction with nucleophile led to the formation of carbamate. This modification of hydroxyl groups of glycosaminoglycans preserves the carboxyl groups and retains properties of polyelectrolyte. This method affords derivatives easily and the reaction condition correlates with degree of substitution. The experimental results show the effect of reaction conditions (reaction time, ratio of reactants) and effect of substitution on biodegradability. The obtained materials were characterized by nuclear magnetic resonance and Fourier transform infrared spectroscopy. Copyright (c) 2006 Wiley Periodicals, Inc.
- 650 _2
- $a zvířata $7 D000818
- 650 _2
- $a biokompatibilní materiály $x chemická syntéza $7 D001672
- 650 _2
- $a biodegradace $7 D001673
- 650 _2
- $a karbamáty $x chemická syntéza $7 D002219
- 650 _2
- $a skot $7 D002417
- 650 _2
- $a gelová chromatografie $7 D002850
- 650 _2
- $a bromkyan $x chemie $7 D003488
- 650 _2
- $a glykosaminoglykany $x chemie $7 D006025
- 650 _2
- $a kyselina hyaluronová $x chemická syntéza $x chemie $7 D006820
- 650 _2
- $a hyaluronoglukosaminidasa $x farmakologie $7 D006821
- 650 _2
- $a hydroxylový radikál $x chemie $7 D017665
- 650 _2
- $a kinetika $7 D007700
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a nukleární magnetická rezonance biomolekulární $7 D019906
- 650 _2
- $a rozpustnost $7 D012995
- 650 _2
- $a spektroskopie infračervená s Fourierovou transformací $7 D017550
- 650 _2
- $a viskozita $7 D014783
- 650 _2
- $a voda $x chemie $7 D014867
- 650 _2
- $a financování organizované $7 D005381
- 700 1_
- $a Bystrický, Slavomír, $d 1947- $7 xx0322827
- 700 1_
- $a Steiner, Bohumil $7 xx0100568
- 700 1_
- $a Machová, Eva $7 xx0128741
- 700 1_
- $a Koóš, Miroslav, $d 1952-2021 $7 xx0303927
- 700 1_
- $a Velebný, Vladimír $7 jo2012691878
- 700 1_
- $a Krčmář, Martin $7 xx0098964
- 773 0_
- $w MED00000777 $t Biopolymers $g Roč. 82, č. 1 (2006), s. 74-79 $x 0006-3525
- 910 __
- $a ABA008 $b x $y 9 $z 0
- 990 __
- $a 20090312170439 $b ABA008
- 991 __
- $a 20240918124018 $b ABA008
- 999 __
- $a ok $b bmc $g 644282 $s 497193
- BAS __
- $a 3
- BMC __
- $a 2006 $b 82 $c 1 $d 74-79 $i 0006-3525 $m Biopolymers $x MED00000777
- LZP __
- $a 2009-B1/vtme
