Sixty-five samples of cerebrospinal fluid (CSF) were evaluated using an automated cytoflow method with the CD-Sapphire hematology analyzer in order to investigate possible relationships between cell population patterns and diagnostic groups and better understand the biology of neurological disease. A basic panel of CD markers, including CD3/4/8/19/138/HLA-DR, was used to analyze CSF samples from clinical and laboratory confirmed cases of multiple sclerosis, neuroborreliosis, viral and bacterial neuroinfective diseases, malignant infiltrations of meninges and scavenger macrophagic reactions of the central nervous system. The principles of immune response and the contribution of cytological 'disease-related patterns' for these nosological entities are described. The distinct patterns of lymphocyte subpopulations in neuroborreliosis appear to be characteristic and could possibly serve as diagnostic indicators. Further verification and research will be necessary to clarify the significance and nature of CD4+ CD8+ positive subset in cerebrospinal fluid.

• MeSH
• CD antigeny izolace a purifikace   MeSH
• lidé MeSH
• lymská neuroborelióza diagnóza   MeSH
• meningeální nádory diagnóza   MeSH
• monoklonální protilátky imunologie   izolace a purifikace   MeSH
• mozkomíšní mok imunologie   MeSH
• nemoci centrálního nervového systému diagnóza   imunologie   MeSH
• průtoková cytometrie metody   využití   MeSH
• roztroušená skleróza diagnóza   MeSH
• Check Tag
• lidé MeSH