The substitution of insects for laboratory animals in toxicity testing is likely to become a reality in the framework of prescreening. Haematotoxicological studies of newly developed chemicals, such as food components, drugs, etc. performed on insects can offer advantages in, for example, environmental toxicology. Reliable routine predictions should produce an increase in our knowledge of haemocyte physiology. Although the differences between human physiology and morphology and those of insects are great, the basic functions of insect haemocytes and mammalian leukocytes appear not to have changed during evolution. The use of insects in haematotoxicity assays represents a preclinical testing strategy which will lower costs, accelerate screening and offer ethical benefits.

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• alternativy výzkumu na zvířatech MeSH
• druhová specificita MeSH
• hmyz účinky léků   MeSH
• krevní buňky účinky léků   MeSH
• krevní nemoci chemicky indukované   MeSH
• prediktivní hodnota testů MeSH
• preklinické hodnocení léčiv metody   MeSH
• testy toxicity metody   MeSH
• xenobiotika toxicita   MeSH
• zvířata MeSH
• Check Tag
• zvířata MeSH
• Publikační typ
• přehledy MeSH