Cell cycle represents not only a tightly orchestrated mechanism of cell replication and cell division but it also plays an important role in regulation of cell fate decision. Particularly in the context of pluripotent stem cells or multipotent progenitor cells, regulation of cell fate decision is of paramount importance. It has been shown that human embryonic stem cells (hESCs) show unique cell cycle characteristics, such as short doubling time due to abbreviated G1 phase; these properties change with the onset of differentiation. This review summarizes the current understanding of cell cycle regulation in hESCs. We discuss cell cycle properties as well as regulatory machinery governing cell cycle progression of undifferentiated hESCs. Additionally, we provide evidence that long-term culture of hESCs is accompanied by changes in cell cycle properties as well as configuration of several cell cycle regulatory molecules.

• MeSH
• buněčná diferenciace MeSH
• buněčné kultury MeSH
• buněčný cyklus fyziologie   MeSH
• embryonální kmenové buňky cytologie   fyziologie   MeSH
• kontrolní body buněčného cyklu fyziologie   MeSH
• lidé MeSH
• pluripotentní kmenové buňky cytologie   fyziologie   MeSH
• proteiny buněčného cyklu metabolismus   fyziologie   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH