HPV-vaccinated women develop CIN III very rarely. We have identified a study group of 38 such patients and showed that a specific HPV genotype prevalence in those cases equals the prevalence of HPV genotypes in CIN III present in the general Czech population. In all cases, CIN III was diagnosed within 3 years after having completed the HPV vaccination. We conclude that dysplasia was present before the vaccination in those women. A history of abnormal pre-vaccination PAP smear result (present in 78 % of women in the study group) and age of over 17 by the time of vaccination completion (97 % of women in the study group) are identified as probable factors increasing the risk of CIN III development after HPV vaccination.

• MeSH
• biopsie MeSH
• dospělí MeSH
• dysplazie děložního hrdla patologie   virologie   MeSH
• genotyp MeSH
• lidé MeSH
• mladiství MeSH
• nádory děložního čípku patologie   virologie   MeSH
• Papillomaviridae klasifikace   MeSH
• vakcinace * MeSH
• vakcíny proti papilomavirům imunologie   MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• mladiství MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH