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25438924 OR Aggressive and nonaggressive translocation t(6 Dotaz Zobrazit nápovědu

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Článek

Aggressive and nonaggressive translocation t(6;11) renal cell carcinoma: comparative study of 6 cases and review of the literature

Five cases of t(6;11) RCCs behaved nonaggressively, and 1 was carcinoma with aggressive behavior. ...

Peckova, Kvetoslava
Autor Peckova, Kvetoslava Department of Pathology, Faculty of Medicine, University Hospital Plzeň, Charles University, Pilsen, Czech Republic
Vanecek, Tomas
Autor Vanecek, Tomas Department of Pathology, Faculty of Medicine, University Hospital Plzeň, Charles University, Pilsen, Czech Republic
Martinek, Petr
Autor Martinek, Petr Department of Pathology, Faculty of Medicine, University Hospital Plzeň, Charles University, Pilsen, Czech Republic
Spagnolo, Dominic
Autor Spagnolo, Dominic Department of Pathology, PathWest Laboratory Medicine WA, Nedlands, Australia
Kuroda, Naoto
Autor Kuroda, Naoto Department of Diagnostic Pathology, Kochi Red Cross Hospital, Kochi, Japan
Brunelli, Matteo
Autor Brunelli, Matteo Department of Pathology and Diagnostic, University of Verona, Verona, Italy
Vranic, Semir
Autor Vranic, Semir Department of Pathology, Clinical Center of the University of Sarajevo, Sarajevo, Bosnia and Herzegovina
Djuricic, Slavisa
Autor Djuricic, Slavisa Department of Pathology, Mother and Child Health Institute of Serbia, Belgrade, Serbia
Rotterova, Pavla
Autor Rotterova, Pavla Department of Pathology, Faculty of Medicine, University Hospital Plzeň, Charles University, Pilsen, Czech Republic
Daum, Ondrej
Autor Daum, Ondrej Department of Pathology, Faculty of Medicine, University Hospital Plzeň, Charles University, Pilsen, Czech Republic

Annals of diagnostic pathology. 2014 ; 18 (6) : 351-7. [pub] 20141013

Ann. diagn. pathol.
ISSN 1532-8198
Medvik
Zdroj

UNLABELLED: t(6;11) renal cell carcinoma (RCC) has been recognized as a rare and mostly nonaggressive tumor (NAT). The criteria for distinguishing aggressive tumors (AT) from NATs are not well established. A total of 6 cases were selected for the study. Five cases of t(6;11) RCCs behaved nonaggressively, and 1 was carcinoma with aggressive behavior. The tumors were analyzed morphologically using immunohistochemistry and by molecular-genetic methods. The specimen of aggressive t(6;11) RCC was from a 77-year-old woman who died of the disease 2.5 months after diagnosis. The specimens of nonaggressive t(6;11) RCCs were from 3 women and 2 men whose ages range between 15 and 54 years. Follow-up was available in all cases (2.5 months-8 years). The tumor size ranged from 3 to 14 cm in nonaggressive t(6;11) RCC. In the aggressive carcinoma, the tumor size was 12 cm. All tumors (6/6) were well circumscribed. Aggressive t(6;11) RCC was widely necrotic. Six (100%) of 6 all tumors displayed a solid/alveolar architecture with occasional tubules and pseudorosettes. Pseudopapillary formations lined by bizarre polymorphic cells were found focally in the aggressive t(6;11) RCC case. Mitoses, though rare, were found as well. All cases (AT and NAT) were positive for HMB-45, Melan-A, Cathepsin K, and cytokeratins. CD117 positivity was seen in 4 of 5 NATs, as well as in the primary and metastatic lesions of the AT. mTOR was positive in 2 of 5 NATs and vimentin in 4 of 5 NATs. Vimentin was negative in the primary lesion of the AT, as well as in the metastasis found in the adrenal gland. Translocation t(6;11)(Alpha-TFEB) or TFEB break was detected in 4 of 5 NATs and in the AT case. Aggressive tumor showed amplification of TFEB locus. Losses of part of chromosome 1 and chromosome 22 were found in 1 of 5 NATs and in the AT. CONCLUSIONS: (1) Aggressive t(6;11) RCCs generally occur in the older population in comparison with their indolent counterparts. (2) In regard to the histologic findings in ATs, 3 of 5 so far published cases were morphologically not typical for t(6;11) RCC. Of the 3 cases, 2 cases lacked a small cell component and 1 closely mimicked clear cell-type RCC. (3) Necroses were only present in aggressive t(6;11) RCC. (4) Amplification of TFEB locus was also found only in the aggressive t(6;11) RCC.