Unconjugated bilirubin (UCB) is known to be one of the most potent endogenous antioxidant substances. While hyperbilirubinemia has long been recognized as an ominous sign of liver dysfunction, recent data strongly indicate that mildly elevated bilirubin (BLB) levels can be protective against an array of diseases associated with increased oxidative stress. These clinical observations are supported by new discoveries relating to the role of BLB in immunosuppression and inhibition of protein phosphorylation, resulting in the modulation of intracellular signaling pathways in vascular biology and cancer, among others. Collectively, the evidence suggests that targeting BLB metabolism could be considered a potential therapeutic approach to ameliorate a variety of conditions.

• MeSH
• antioxidancia metabolismus   MeSH
• bilirubin metabolismus   MeSH
• diabetes mellitus metabolismus   MeSH
• hyperbilirubinemie metabolismus   MeSH
• kardiovaskulární nemoci metabolismus   MeSH
• lidé MeSH
• nádory metabolismus   MeSH
• nemoci nervového systému metabolismus   MeSH
• oxidace-redukce MeSH
• oxidační stres MeSH
• signální transdukce * MeSH
• zánět metabolismus   MeSH
• zvířata MeSH
• Check Tag
• lidé MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH