Vector-borne diseases cause over 700,000 deaths annually and represent 17% of all infectious illnesses worldwide. This public health menace highlights the importance of understanding how arthropod vectors, microbes and their mammalian hosts interact. Currently, an emphasis of the scientific enterprise is at the vector-host interface where human pathogens are acquired and transmitted. At this spatial junction, arthropod effector molecules are secreted, enabling microbial pathogenesis and disease. Extracellular vesicles manipulate signaling networks by carrying proteins, lipids, carbohydrates and regulatory nucleic acids. Therefore, they are well positioned to aid in cell-to-cell communication and mediate molecular interactions. This Review briefly discusses exosome and microvesicle biogenesis, their cargo, and the role that nanovesicles play during pathogen spread, host colonization and disease pathogenesis. We then focus on the role of extracellular vesicles in dictating microbial pathogenesis and host immunity during transmission of vector-borne pathogens.

• MeSH
• amébiáza parazitologie   přenos   MeSH
• členovci - vektory * mikrobiologie   parazitologie   MeSH
• Culicidae mikrobiologie   parazitologie   MeSH
• exozómy imunologie   mikrobiologie   parazitologie   MeSH
• extracelulární vezikuly * imunologie   mikrobiologie   parazitologie   MeSH
• filarióza parazitologie   přenos   MeSH
• Hemiptera mikrobiologie   parazitologie   MeSH
• imunomodulace MeSH
• infekce přenášené vektorem MeSH
• interakce hostitele a parazita imunologie   fyziologie   MeSH
• leishmanióza parazitologie   přenos   MeSH
• lidé MeSH
• malárie parazitologie   přenos   MeSH
• nemoci přenášené vektory * mikrobiologie   parazitologie   přenos   MeSH
• Psychodidae mikrobiologie   parazitologie   MeSH
• trypanozomiáza parazitologie   přenos   MeSH
• virové nemoci mikrobiologie   přenos   MeSH
• zvířata MeSH
• Check Tag
• lidé MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH
• Research Support, N.I.H., Extramural MeSH