Progress in mass spectroscopy of posttranslational oxidative modifications has enabled researchers to experimentally verify the concept of redox signaling. We focus here on redox signaling originating from mitochondria under physiological situations, discussing mechanisms of transient redox burst in mitochondria, as well as the possible ways to transfer such redox signals to specific extramitochondrial targets. A role of peroxiredoxins is described which enables redox relay to other targets. Examples of mitochondrial redox signaling are discussed: initiation of hypoxia-inducible factor (HIF) responses; retrograde redox signaling to PGC1α during exercise in skeletal muscle; redox signaling in innate immune cells; redox stimulation of insulin secretion, and other physiological situations.

• MeSH
• beta-buňky metabolismus   MeSH
• hypoxie metabolismus   MeSH
• imunita fyziologie   MeSH
• kosterní svaly metabolismus   MeSH
• mitochondrie metabolismus   MeSH
• oxidace-redukce MeSH
• peroxid vodíku metabolismus   MeSH
• peroxiredoxiny MeSH
• posttranslační úpravy proteinů MeSH
• reaktivní formy kyslíku metabolismus   MeSH
• signální transdukce fyziologie   MeSH
• superoxidy metabolismus   MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH