The sarco/endoplasmic reticulum calcium ATPase (SERCA), which plays a key role in the maintenance of Ca2+ ion homeostasis, is an extensively studied enzyme, the inhibition of which has a considerable impact on cell life and death decision. To date, several SERCA inhibitors have been thoroughly studied and the most notable one, a derivative of the sesquiterpene lactone thapsigargin, is gradually approaching a clinical application. Meanwhile, new compounds with SERCA-inhibiting properties of natural, synthetic, or semisynthetic origin are being discovered and/or developed; some of these might also be suitable for the development of new drugs with improved performance. This review brings an up-to-date comprehensive overview of recently discovered compounds with the potential of SERCA inhibition, discusses their mechanism of action, and highlights their potential clinical applications, such as cancer treatment.

• MeSH
• antitumorózní látky chemie   farmakologie   terapeutické užití   MeSH
• genové regulační sítě účinky léků   genetika   MeSH
• inhibitory enzymů chemie   farmakologie   terapeutické užití   MeSH
• lidé MeSH
• nádory farmakoterapie   enzymologie   MeSH
• sarkoplazmatická Ca2+-ATPáza antagonisté a inhibitory   chemie   genetika   MeSH
• sekundární struktura proteinů MeSH
• zvířata MeSH
• Check Tag
• lidé MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• přehledy MeSH