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Autor
Babiar, Donna 1 Bednarik, Josef 1 Bril, Vera 1 Dimachkie, Mazen M 1 Distad, B Jane 1 Freimer, Miriam L 1 Griffin, Rhonda 1 Hon, Petr 1 Kostera-Pruszczyk, Anna 1 Köhler, Wolfgang 1 Lin, Jiang 1 Magnus, Tim 1 Mondou, Elsa 1 Mozaffar, Tahseen 1 Nicolle, Michael W 1 Nowak, Richard J 1 Pascuzzi, Robert M 1 Pulley, Michael T 1 Querolt Coll, Montse 1 Rivner, Michael 1
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Centrum Neurologii Klinicznej Krakow ... 1 Department of Neurology Kaunas Clinic... 1 Department of Neurology Masaryk Unive... 1 Department of Neurology Medical Unive... 1 Department of Neurology The Ohio Stat... 1 Department of Neurology Yale Universi... 1 East Tallinn Central Hospital Estonia 1 FKH Hubertusburg Klinik Fuer Neurolog... 1 Fakultni Nemocnice Ostrava Neurologic... 1 From the Toronto General Hospital Tor... 1 Grifols Bioscience Research Group Res... 1 Grifols Bioscience Research Group San... 1 Indiana School of Medicine Indianapolis 1 Jahn Ferenc Del pesti Korhaz es Rende... 1 London Health Sciences Centre Western... 1 Neurology EMG Laboratory Augusta Univ... 1 The University of Kansas Medical Center 1 Universitaetsklinikum Hamburg Eppendo... 1 University of California Irvine Orange 1 University of Florida Health Science ... 1
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Autor
Babiar, Donna 1 Bednarik, Josef 1 Bril, Vera 1 Dimachkie, Mazen M 1 Distad, B Jane 1 Freimer, Miriam L 1 Griffin, Rhonda 1 Hon, Petr 1 Kostera-Pruszczyk, Anna 1 Köhler, Wolfgang 1 Lin, Jiang 1 Magnus, Tim 1 Mondou, Elsa 1 Mozaffar, Tahseen 1 Nicolle, Michael W 1 Nowak, Richard J 1 Pascuzzi, Robert M 1 Pulley, Michael T 1 Querolt Coll, Montse 1 Rivner, Michael 1
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Pracoviště
Centrum Neurologii Klinicznej Krakow ... 1 Department of Neurology Kaunas Clinic... 1 Department of Neurology Masaryk Unive... 1 Department of Neurology Medical Unive... 1 Department of Neurology The Ohio Stat... 1 Department of Neurology Yale Universi... 1 East Tallinn Central Hospital Estonia 1 FKH Hubertusburg Klinik Fuer Neurolog... 1 Fakultni Nemocnice Ostrava Neurologic... 1 From the Toronto General Hospital Tor... 1 Grifols Bioscience Research Group Res... 1 Grifols Bioscience Research Group San... 1 Indiana School of Medicine Indianapolis 1 Jahn Ferenc Del pesti Korhaz es Rende... 1 London Health Sciences Centre Western... 1 Neurology EMG Laboratory Augusta Univ... 1 The University of Kansas Medical Center 1 Universitaetsklinikum Hamburg Eppendo... 1 University of California Irvine Orange 1 University of Florida Health Science ... 1
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36270895 OR Randomized Double-Blind Placebo-Controlled Trial of the Corticosteroid-Sparing Effects of Immunoglobulin in Myasthenia Gravis Dotaz Zobrazit nápovědu
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Bril, Vera
Autor Bril, Vera From the Toronto General Hospital (V.B.), Toronto, Ontario, Canada Centrum Neurologii Klinicznej (A.S.), Krakow, Poland Department of Neurology (A.V.), Kaunas Clinics, Hospital of Lithuanian University of Health Sciences, Lithuania Jahn Ferenc Del-pesti Korhaz es Rendelointezet Neurologiai Osztaly (C.R.), Budapest, Hungary Department of Neurology (A.K.-P.), Medical University of Warsaw, Poland, ERN EURO NMD Fakultni Nemocnice Ostrava (P.H.), Neurologicka Klinika, Ostrava-Poruba, Czech Republic Department of Neurology (J.B.), Masaryk University, University Hospital Brno and Faculty of Medicine, Czech Republic Vseobecna Fakultni Nemocnice v Praze (M.T.), Neurologicka Klinika, Centrum Myasthenia Gravis, Praha, Czech Republic FKH Hubertusburg (W.K.), Klinik Fuer Neurologie und Neurologische, Intensivmedizin, Wermsdorf, Germany East Tallinn Central Hospital (T.T.), Estonia Department of Neurology (R.J.N.), Yale University School of Medicine, New Haven, CT University of California (Tahseen Mozaffar), Irvine, Orange Department of Neurology (M.L.F.), The Ohio State University, Columbus London Health Sciences Centre (M.W.N.), Western University, Ontario, Canada Universitaetsklinikum Hamburg Eppendorf (Tim Magnus), Klinik und Poliklinik Fuer Neurologie, Neurologische Studienzentrale, Hamburg, Germany University of Florida Health Science Center (M.T.P.), Jacksonville, FL Neurology/EMG Laboratory (M.R.), Augusta University, GA The University of Kansas Medical Center (M.M.D.) University of Washington (B.J.D.), Seattle Indiana School of Medicine (R.M.P.), Indianapolis Grifols Bioscience Research Group (D.B., J.L., R.G., E.M.), Research Triangle Park, NC and Grifols Bioscience Research Group (M.Q.C.), Sant Cugat, Spain. vera.bril@utoronto.ca
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Szczudlik, Andrzej
Autor Szczudlik, Andrzej From the Toronto General Hospital (V.B.), Toronto, Ontario, Canada Centrum Neurologii Klinicznej (A.S.), Krakow, Poland Department of Neurology (A.V.), Kaunas Clinics, Hospital of Lithuanian University of Health Sciences, Lithuania Jahn Ferenc Del-pesti Korhaz es Rendelointezet Neurologiai Osztaly (C.R.), Budapest, Hungary Department of Neurology (A.K.-P.), Medical University of Warsaw, Poland, ERN EURO NMD Fakultni Nemocnice Ostrava (P.H.), Neurologicka Klinika, Ostrava-Poruba, Czech Republic Department of Neurology (J.B.), Masaryk University, University Hospital Brno and Faculty of Medicine, Czech Republic Vseobecna Fakultni Nemocnice v Praze (M.T.), Neurologicka Klinika, Centrum Myasthenia Gravis, Praha, Czech Republic FKH Hubertusburg (W.K.), Klinik Fuer Neurologie und Neurologische, Intensivmedizin, Wermsdorf, Germany East Tallinn Central Hospital (T.T.), Estonia Department of Neurology (R.J.N.), Yale University School of Medicine, New Haven, CT University of California (Tahseen Mozaffar), Irvine, Orange Department of Neurology (M.L.F.), The Ohio State University, Columbus London Health Sciences Centre (M.W.N.), Western University, Ontario, Canada Universitaetsklinikum Hamburg Eppendorf (Tim Magnus), Klinik und Poliklinik Fuer Neurologie, Neurologische Studienzentrale, Hamburg, Germany University of Florida Health Science Center (M.T.P.), Jacksonville, FL Neurology/EMG Laboratory (M.R.), Augusta University, GA The University of Kansas Medical Center (M.M.D.) University of Washington (B.J.D.), Seattle Indiana School of Medicine (R.M.P.), Indianapolis Grifols Bioscience Research Group (D.B., J.L., R.G., E.M.), Research Triangle Park, NC and Grifols Bioscience Research Group (M.Q.C.), Sant Cugat, Spain
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Vaitkus, Antanas
Autor Vaitkus, Antanas From the Toronto General Hospital (V.B.), Toronto, Ontario, Canada Centrum Neurologii Klinicznej (A.S.), Krakow, Poland Department of Neurology (A.V.), Kaunas Clinics, Hospital of Lithuanian University of Health Sciences, Lithuania Jahn Ferenc Del-pesti Korhaz es Rendelointezet Neurologiai Osztaly (C.R.), Budapest, Hungary Department of Neurology (A.K.-P.), Medical University of Warsaw, Poland, ERN EURO NMD Fakultni Nemocnice Ostrava (P.H.), Neurologicka Klinika, Ostrava-Poruba, Czech Republic Department of Neurology (J.B.), Masaryk University, University Hospital Brno and Faculty of Medicine, Czech Republic Vseobecna Fakultni Nemocnice v Praze (M.T.), Neurologicka Klinika, Centrum Myasthenia Gravis, Praha, Czech Republic FKH Hubertusburg (W.K.), Klinik Fuer Neurologie und Neurologische, Intensivmedizin, Wermsdorf, Germany East Tallinn Central Hospital (T.T.), Estonia Department of Neurology (R.J.N.), Yale University School of Medicine, New Haven, CT University of California (Tahseen Mozaffar), Irvine, Orange Department of Neurology (M.L.F.), The Ohio State University, Columbus London Health Sciences Centre (M.W.N.), Western University, Ontario, Canada Universitaetsklinikum Hamburg Eppendorf (Tim Magnus), Klinik und Poliklinik Fuer Neurologie, Neurologische Studienzentrale, Hamburg, Germany University of Florida Health Science Center (M.T.P.), Jacksonville, FL Neurology/EMG Laboratory (M.R.), Augusta University, GA The University of Kansas Medical Center (M.M.D.) University of Washington (B.J.D.), Seattle Indiana School of Medicine (R.M.P.), Indianapolis Grifols Bioscience Research Group (D.B., J.L., R.G., E.M.), Research Triangle Park, NC and Grifols Bioscience Research Group (M.Q.C.), Sant Cugat, Spain
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Rozsa, Csilla
Autor Rozsa, Csilla From the Toronto General Hospital (V.B.), Toronto, Ontario, Canada Centrum Neurologii Klinicznej (A.S.), Krakow, Poland Department of Neurology (A.V.), Kaunas Clinics, Hospital of Lithuanian University of Health Sciences, Lithuania Jahn Ferenc Del-pesti Korhaz es Rendelointezet Neurologiai Osztaly (C.R.), Budapest, Hungary Department of Neurology (A.K.-P.), Medical University of Warsaw, Poland, ERN EURO NMD Fakultni Nemocnice Ostrava (P.H.), Neurologicka Klinika, Ostrava-Poruba, Czech Republic Department of Neurology (J.B.), Masaryk University, University Hospital Brno and Faculty of Medicine, Czech Republic Vseobecna Fakultni Nemocnice v Praze (M.T.), Neurologicka Klinika, Centrum Myasthenia Gravis, Praha, Czech Republic FKH Hubertusburg (W.K.), Klinik Fuer Neurologie und Neurologische, Intensivmedizin, Wermsdorf, Germany East Tallinn Central Hospital (T.T.), Estonia Department of Neurology (R.J.N.), Yale University School of Medicine, New Haven, CT University of California (Tahseen Mozaffar), Irvine, Orange Department of Neurology (M.L.F.), The Ohio State University, Columbus London Health Sciences Centre (M.W.N.), Western University, Ontario, Canada Universitaetsklinikum Hamburg Eppendorf (Tim Magnus), Klinik und Poliklinik Fuer Neurologie, Neurologische Studienzentrale, Hamburg, Germany University of Florida Health Science Center (M.T.P.), Jacksonville, FL Neurology/EMG Laboratory (M.R.), Augusta University, GA The University of Kansas Medical Center (M.M.D.) University of Washington (B.J.D.), Seattle Indiana School of Medicine (R.M.P.), Indianapolis Grifols Bioscience Research Group (D.B., J.L., R.G., E.M.), Research Triangle Park, NC and Grifols Bioscience Research Group (M.Q.C.), Sant Cugat, Spain
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Kostera-Pruszczyk, Anna
Autor Kostera-Pruszczyk, Anna ORCID From the Toronto General Hospital (V.B.), Toronto, Ontario, Canada Centrum Neurologii Klinicznej (A.S.), Krakow, Poland Department of Neurology (A.V.), Kaunas Clinics, Hospital of Lithuanian University of Health Sciences, Lithuania Jahn Ferenc Del-pesti Korhaz es Rendelointezet Neurologiai Osztaly (C.R.), Budapest, Hungary Department of Neurology (A.K.-P.), Medical University of Warsaw, Poland, ERN EURO NMD Fakultni Nemocnice Ostrava (P.H.), Neurologicka Klinika, Ostrava-Poruba, Czech Republic Department of Neurology (J.B.), Masaryk University, University Hospital Brno and Faculty of Medicine, Czech Republic Vseobecna Fakultni Nemocnice v Praze (M.T.), Neurologicka Klinika, Centrum Myasthenia Gravis, Praha, Czech Republic FKH Hubertusburg (W.K.), Klinik Fuer Neurologie und Neurologische, Intensivmedizin, Wermsdorf, Germany East Tallinn Central Hospital (T.T.), Estonia Department of Neurology (R.J.N.), Yale University School of Medicine, New Haven, CT University of California (Tahseen Mozaffar), Irvine, Orange Department of Neurology (M.L.F.), The Ohio State University, Columbus London Health Sciences Centre (M.W.N.), Western University, Ontario, Canada Universitaetsklinikum Hamburg Eppendorf (Tim Magnus), Klinik und Poliklinik Fuer Neurologie, Neurologische Studienzentrale, Hamburg, Germany University of Florida Health Science Center (M.T.P.), Jacksonville, FL Neurology/EMG Laboratory (M.R.), Augusta University, GA The University of Kansas Medical Center (M.M.D.) University of Washington (B.J.D.), Seattle Indiana School of Medicine (R.M.P.), Indianapolis Grifols Bioscience Research Group (D.B., J.L., R.G., E.M.), Research Triangle Park, NC and Grifols Bioscience Research Group (M.Q.C.), Sant Cugat, Spain
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Hon, Petr
Autor Hon, Petr From the Toronto General Hospital (V.B.), Toronto, Ontario, Canada Centrum Neurologii Klinicznej (A.S.), Krakow, Poland Department of Neurology (A.V.), Kaunas Clinics, Hospital of Lithuanian University of Health Sciences, Lithuania Jahn Ferenc Del-pesti Korhaz es Rendelointezet Neurologiai Osztaly (C.R.), Budapest, Hungary Department of Neurology (A.K.-P.), Medical University of Warsaw, Poland, ERN EURO NMD Fakultni Nemocnice Ostrava (P.H.), Neurologicka Klinika, Ostrava-Poruba, Czech Republic Department of Neurology (J.B.), Masaryk University, University Hospital Brno and Faculty of Medicine, Czech Republic Vseobecna Fakultni Nemocnice v Praze (M.T.), Neurologicka Klinika, Centrum Myasthenia Gravis, Praha, Czech Republic FKH Hubertusburg (W.K.), Klinik Fuer Neurologie und Neurologische, Intensivmedizin, Wermsdorf, Germany East Tallinn Central Hospital (T.T.), Estonia Department of Neurology (R.J.N.), Yale University School of Medicine, New Haven, CT University of California (Tahseen Mozaffar), Irvine, Orange Department of Neurology (M.L.F.), The Ohio State University, Columbus London Health Sciences Centre (M.W.N.), Western University, Ontario, Canada Universitaetsklinikum Hamburg Eppendorf (Tim Magnus), Klinik und Poliklinik Fuer Neurologie, Neurologische Studienzentrale, Hamburg, Germany University of Florida Health Science Center (M.T.P.), Jacksonville, FL Neurology/EMG Laboratory (M.R.), Augusta University, GA The University of Kansas Medical Center (M.M.D.) University of Washington (B.J.D.), Seattle Indiana School of Medicine (R.M.P.), Indianapolis Grifols Bioscience Research Group (D.B., J.L., R.G., E.M.), Research Triangle Park, NC and Grifols Bioscience Research Group (M.Q.C.), Sant Cugat, Spain
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Bednarik, Josef
Autor Autorita ORCID From the Toronto General Hospital (V.B.), Toronto, Ontario, Canada Centrum Neurologii Klinicznej (A.S.), Krakow, Poland Department of Neurology (A.V.), Kaunas Clinics, Hospital of Lithuanian University of Health Sciences, Lithuania Jahn Ferenc Del-pesti Korhaz es Rendelointezet Neurologiai Osztaly (C.R.), Budapest, Hungary Department of Neurology (A.K.-P.), Medical University of Warsaw, Poland, ERN EURO NMD Fakultni Nemocnice Ostrava (P.H.), Neurologicka Klinika, Ostrava-Poruba, Czech Republic Department of Neurology (J.B.), Masaryk University, University Hospital Brno and Faculty of Medicine, Czech Republic Vseobecna Fakultni Nemocnice v Praze (M.T.), Neurologicka Klinika, Centrum Myasthenia Gravis, Praha, Czech Republic FKH Hubertusburg (W.K.), Klinik Fuer Neurologie und Neurologische, Intensivmedizin, Wermsdorf, Germany East Tallinn Central Hospital (T.T.), Estonia Department of Neurology (R.J.N.), Yale University School of Medicine, New Haven, CT University of California (Tahseen Mozaffar), Irvine, Orange Department of Neurology (M.L.F.), The Ohio State University, Columbus London Health Sciences Centre (M.W.N.), Western University, Ontario, Canada Universitaetsklinikum Hamburg Eppendorf (Tim Magnus), Klinik und Poliklinik Fuer Neurologie, Neurologische Studienzentrale, Hamburg, Germany University of Florida Health Science Center (M.T.P.), Jacksonville, FL Neurology/EMG Laboratory (M.R.), Augusta University, GA The University of Kansas Medical Center (M.M.D.) University of Washington (B.J.D.), Seattle Indiana School of Medicine (R.M.P.), Indianapolis Grifols Bioscience Research Group (D.B., J.L., R.G., E.M.), Research Triangle Park, NC and Grifols Bioscience Research Group (M.Q.C.), Sant Cugat, Spain
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Tyblova, Michaela
Autor Tyblova, Michaela From the Toronto General Hospital (V.B.), Toronto, Ontario, Canada Centrum Neurologii Klinicznej (A.S.), Krakow, Poland Department of Neurology (A.V.), Kaunas Clinics, Hospital of Lithuanian University of Health Sciences, Lithuania Jahn Ferenc Del-pesti Korhaz es Rendelointezet Neurologiai Osztaly (C.R.), Budapest, Hungary Department of Neurology (A.K.-P.), Medical University of Warsaw, Poland, ERN EURO NMD Fakultni Nemocnice Ostrava (P.H.), Neurologicka Klinika, Ostrava-Poruba, Czech Republic Department of Neurology (J.B.), Masaryk University, University Hospital Brno and Faculty of Medicine, Czech Republic Vseobecna Fakultni Nemocnice v Praze (M.T.), Neurologicka Klinika, Centrum Myasthenia Gravis, Praha, Czech Republic FKH Hubertusburg (W.K.), Klinik Fuer Neurologie und Neurologische, Intensivmedizin, Wermsdorf, Germany East Tallinn Central Hospital (T.T.), Estonia Department of Neurology (R.J.N.), Yale University School of Medicine, New Haven, CT University of California (Tahseen Mozaffar), Irvine, Orange Department of Neurology (M.L.F.), The Ohio State University, Columbus London Health Sciences Centre (M.W.N.), Western University, Ontario, Canada Universitaetsklinikum Hamburg Eppendorf (Tim Magnus), Klinik und Poliklinik Fuer Neurologie, Neurologische Studienzentrale, Hamburg, Germany University of Florida Health Science Center (M.T.P.), Jacksonville, FL Neurology/EMG Laboratory (M.R.), Augusta University, GA The University of Kansas Medical Center (M.M.D.) University of Washington (B.J.D.), Seattle Indiana School of Medicine (R.M.P.), Indianapolis Grifols Bioscience Research Group (D.B., J.L., R.G., E.M.), Research Triangle Park, NC and Grifols Bioscience Research Group (M.Q.C.), Sant Cugat, Spain
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Köhler, Wolfgang
Autor Köhler, Wolfgang From the Toronto General Hospital (V.B.), Toronto, Ontario, Canada Centrum Neurologii Klinicznej (A.S.), Krakow, Poland Department of Neurology (A.V.), Kaunas Clinics, Hospital of Lithuanian University of Health Sciences, Lithuania Jahn Ferenc Del-pesti Korhaz es Rendelointezet Neurologiai Osztaly (C.R.), Budapest, Hungary Department of Neurology (A.K.-P.), Medical University of Warsaw, Poland, ERN EURO NMD Fakultni Nemocnice Ostrava (P.H.), Neurologicka Klinika, Ostrava-Poruba, Czech Republic Department of Neurology (J.B.), Masaryk University, University Hospital Brno and Faculty of Medicine, Czech Republic Vseobecna Fakultni Nemocnice v Praze (M.T.), Neurologicka Klinika, Centrum Myasthenia Gravis, Praha, Czech Republic FKH Hubertusburg (W.K.), Klinik Fuer Neurologie und Neurologische, Intensivmedizin, Wermsdorf, Germany East Tallinn Central Hospital (T.T.), Estonia Department of Neurology (R.J.N.), Yale University School of Medicine, New Haven, CT University of California (Tahseen Mozaffar), Irvine, Orange Department of Neurology (M.L.F.), The Ohio State University, Columbus London Health Sciences Centre (M.W.N.), Western University, Ontario, Canada Universitaetsklinikum Hamburg Eppendorf (Tim Magnus), Klinik und Poliklinik Fuer Neurologie, Neurologische Studienzentrale, Hamburg, Germany University of Florida Health Science Center (M.T.P.), Jacksonville, FL Neurology/EMG Laboratory (M.R.), Augusta University, GA The University of Kansas Medical Center (M.M.D.) University of Washington (B.J.D.), Seattle Indiana School of Medicine (R.M.P.), Indianapolis Grifols Bioscience Research Group (D.B., J.L., R.G., E.M.), Research Triangle Park, NC and Grifols Bioscience Research Group (M.Q.C.), Sant Cugat, Spain
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Toomsoo, Toomas
Autor Toomsoo, Toomas From the Toronto General Hospital (V.B.), Toronto, Ontario, Canada Centrum Neurologii Klinicznej (A.S.), Krakow, Poland Department of Neurology (A.V.), Kaunas Clinics, Hospital of Lithuanian University of Health Sciences, Lithuania Jahn Ferenc Del-pesti Korhaz es Rendelointezet Neurologiai Osztaly (C.R.), Budapest, Hungary Department of Neurology (A.K.-P.), Medical University of Warsaw, Poland, ERN EURO NMD Fakultni Nemocnice Ostrava (P.H.), Neurologicka Klinika, Ostrava-Poruba, Czech Republic Department of Neurology (J.B.), Masaryk University, University Hospital Brno and Faculty of Medicine, Czech Republic Vseobecna Fakultni Nemocnice v Praze (M.T.), Neurologicka Klinika, Centrum Myasthenia Gravis, Praha, Czech Republic FKH Hubertusburg (W.K.), Klinik Fuer Neurologie und Neurologische, Intensivmedizin, Wermsdorf, Germany East Tallinn Central Hospital (T.T.), Estonia Department of Neurology (R.J.N.), Yale University School of Medicine, New Haven, CT University of California (Tahseen Mozaffar), Irvine, Orange Department of Neurology (M.L.F.), The Ohio State University, Columbus London Health Sciences Centre (M.W.N.), Western University, Ontario, Canada Universitaetsklinikum Hamburg Eppendorf (Tim Magnus), Klinik und Poliklinik Fuer Neurologie, Neurologische Studienzentrale, Hamburg, Germany University of Florida Health Science Center (M.T.P.), Jacksonville, FL Neurology/EMG Laboratory (M.R.), Augusta University, GA The University of Kansas Medical Center (M.M.D.) University of Washington (B.J.D.), Seattle Indiana School of Medicine (R.M.P.), Indianapolis Grifols Bioscience Research Group (D.B., J.L., R.G., E.M.), Research Triangle Park, NC and Grifols Bioscience Research Group (M.Q.C.), Sant Cugat, Spain
BACKGROUND AND OBJECTIVES: Myasthenia gravis (MG) is an autoimmune disease characterized by dysfunction at the neuromuscular junction. Treatment frequently includes corticosteroids (CSs) and IV immunoglobulin (IVIG). This study was conducted to determine whether immune globulin (human), 10% caprylate/chromatography purified (IGIV-C) could facilitate CS dose reduction in CS-dependent patients with MG. METHODS: In this randomized double-blind placebo-controlled trial, CS-dependent patients with MG (Myasthenia Gravis Foundation of America Class II-Iva; AChR+) received a loading dose of 2 g/kg IGIV-C over 2 days (maximum 80 g/d) or placebo at week 0 (baseline). Maintenance doses (1 g/kg IGIV-C or placebo) were administered every 3 weeks through week 36. Tapering of CS was initiated at week 9 and continued through week 36 unless the patient worsened (quantitative MG score ≥4 points from baseline). CS doses were increased (based on the current CS dose) in patients who worsened. Patients were withdrawn if worsening failed to improve within 6 weeks or if a second CS increase was required. The primary efficacy end point (at week 39) was a ≥50% reduction in CS dose. Secondary and safety end points were assessed throughout the study and follow-up (weeks 42 and 45). The study results and full protocol are available at clinicaltrials.gov/ct2/show/NCT02473965. RESULTS: The primary end point (≥50% reduction in CS dose) showed no significant difference between the IGIV-C treatment (60.0% of patients) and placebo (63.3%). There were no significant differences for secondary end points. Safety data indicated that IGIV-C was well tolerated. DISCUSSION: In this study, IGIV-C was not more effective than placebo in reducing daily CS dose. These results suggest that the effects of IGIV-C and CS are not synergistic and may be mechanistically different. TRIAL REGISTRATION INFORMATION: The trial was registered on clinicaltrialsregister.eu (EudraCT #: 2013-005099-17) and clinicaltrials.gov (identifier NCT02473965). CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that IVIG infusions in adult patients with MG do not increase the percentage of patients achieving a ≥50% reduction in corticosteroid dose compared with placebo.
- MeSH
- dospělí MeSH
- dvojitá slepá metoda MeSH
- hormony kůry nadledvin terapeutické užití MeSH
- intravenózní imunoglobuliny * terapeutické užití MeSH
- lidé MeSH
- myasthenia gravis * farmakoterapie MeSH
- výsledek terapie MeSH
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- dospělí MeSH
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- randomizované kontrolované studie MeSH
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