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Center for Immunology and Inflammator... 1 Center for Transplantation Sciences D... 1 DF HCC Specialized Histopathology Cor... 1 Department of Dermatology Brigham and... 1 Department of Plastic and Hand Surger... 1 Division of Nephrology Massachusetts ... 1 Division of Plastic Surgery Departmen... 1 Program in Dermatopathology Departmen... 1 Schuster Family Transplantation Resea... 1
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Center for Immunology and Inflammator... 1 Center for Transplantation Sciences D... 1 DF HCC Specialized Histopathology Cor... 1 Department of Dermatology Brigham and... 1 Department of Plastic and Hand Surger... 1 Division of Nephrology Massachusetts ... 1 Division of Plastic Surgery Departmen... 1 Program in Dermatopathology Departmen... 1 Schuster Family Transplantation Resea... 1
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Borges, Thiago J
Autor Borges, Thiago J Schuster Family Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
- Abarzua, Phammela
- Gassen, Rodrigo B
- Kollar, Branislav
- Lima-Filho, Mauricio
- Aoyama, Bruno T
- Gluhova, Diana
- Clark, Rachael A
- Islam, Sabina A
- Pomahač, Bohdan, 1971-
NLK
Directory of Open Access Journals
od 2020
PubMed Central
od 2020
Elsevier Open Access Journals
od 2020-04-21
ROAD: Directory of Open Access Scholarly Resources
od 2020
PubMed
35492875
DOI
10.1016/j.xcrm.2022.100559
Knihovny.cz E-zdroje
Limb transplantation is a life-changing procedure for amputees. However, limb recipients have a 6-fold greater rejection rate than solid organ transplant recipients, related in part to greater immunogenicity of the skin. Here, we report a detailed immunological and molecular characterization of individuals who underwent bilateral limb transplantation at our institution. Circulating Th17 cells are increased in limb transplant recipients over time. Molecular characterization of 770 genes in skin biopsies reveals upregulation of T cell effector immune molecules and chemokines, particularly CCL18. Skin antigen-presenting cells primarily express the chemokine CCL18, which binds to the CCR8 receptor. CCL18 treatment recruits more allo-T cells to the skin xenograft in a humanized skin transplantation model, leading to signs of accelerated graft rejection. Blockade of CCR8 remarkedly decreases CCL18-induced allo-T cell infiltration. Our results suggest that targeting the CCL18:CCR8 pathway could be a promising immunosuppressive approach in transplantation.
- MeSH
- chemokiny CC genetika MeSH
- chemokiny * MeSH
- imunosupresiva MeSH
- kůže MeSH
- lidé MeSH
- transplantace kůže * MeSH
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- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, U.S. Gov't, Non-P.H.S. MeSH
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