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Clinical Immunology and Immunology of... 2 Department of Burns and Plastic Surge... 2 Advanced Biomaterials Group Central E... 1 CEITEC Central European Institute of ... 1 Department of Histology and Embryolog... 1 Department of Microbiology St Anne's ... 1 Department of Microbiology St Anne’s ... 1
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- Autor
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Pracoviště
Clinical Immunology and Immunology of... 2 Department of Burns and Plastic Surge... 2 Advanced Biomaterials Group Central E... 1 CEITEC Central European Institute of ... 1 Department of Histology and Embryolog... 1 Department of Microbiology St Anne's ... 1 Department of Microbiology St Anne’s ... 1
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Free Medical Journals od 2001
Free Medical Journals od 2001
PubMed Central od 2022
ProQuest Central od 2001-01-01
Open Access Digital Library od 2001-01-01
ROAD: Directory of Open Access Scholarly Resources od 2001
DOI
10.17221/25/2024-vetmed
stránka časopisu
Knihovny.cz E-zdroje
Pseudomonas aeruginosa poses a significant threat to both immunocompetent and immunocompromised individuals, often resulting in life-threatening infections. With increasing antimicrobial resistance, novel therapeutic strategies are urgently needed. Although animal models are crucial for preclinical studies, limited data are available for porcine models, more specifically for P. aeruginosa complicated skin and soft tissue infections (cSSTIs). This study presents a novel porcine model inducing and sustaining cSSTI for 14 days. Six pigs (120 wounds) were used for the development of infections, and within this group, two pigs (40 wounds) were used to evaluate the progression of the cSSTI infection. The model demonstrated bacterial loads of more than 107 CFU/gram of tissue or higher. The cSSTI fully developed within three days and remained well above these levels until day 14 post-infection. Due to the immunocompetence of this model, all the immunological processes associated with the response to the presence of infection and the wound healing process are preserved.
- Raška, F
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Lipový, B
Autor Lipový, B Department of Burns and Plastic Surgery, Institution Shared with University Hospital Brno, Faculty of Medicine, Masaryk University, Brno, Czech Republic CEITEC - Central European Institute of Technology, Brno University of Technology, Brno, Czech Republic. Electronic address: Lipovy.Bretislav@fnbrno.cz
- Holoubek, J
- Kobzová, Š
- Vacek, L
- Vojtová, L
- Janda, L
- MeSH
- antibakteriální látky farmakologie terapeutické užití MeSH
- antiinfekční látky * farmakologie MeSH
- lidé MeSH
- methicilin rezistentní Staphylococcus aureus * MeSH
- mikrobiální testy citlivosti MeSH
- popálení * MeSH
- stafylokokové infekce * farmakoterapie MeSH
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- lidé MeSH
- Publikační typ
- dopisy MeSH
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