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Department of Biology and Ecology Fac... 1 Department of Biophysical Chemistry a... 1 Department of Experimental Biology Fa... 1 Department of Mathematics Faculty of ... 1 Department of Physics Faculty of Scie... 1 Faculty of Informatics Masaryk Univer... 1 Global Change Research Institute of t... 1 National Centre for Biomolecular Rese... 1
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- Autor
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Pracoviště
Department of Biology and Ecology Fac... 1 Department of Biophysical Chemistry a... 1 Department of Experimental Biology Fa... 1 Department of Mathematics Faculty of ... 1 Department of Physics Faculty of Scie... 1 Faculty of Informatics Masaryk Univer... 1 Global Change Research Institute of t... 1 National Centre for Biomolecular Rese... 1
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Medline Complete (EBSCOhost) od 2000-01-01 do Před 1 rokem
PubMed
33341900
DOI
10.1093/bib/bbaa385
Knihovny.cz E-zdroje
SARS-CoV-2 is an intensively investigated virus from the order Nidovirales (Coronaviridae family) that causes COVID-19 disease in humans. Through enormous scientific effort, thousands of viral strains have been sequenced to date, thereby creating a strong background for deep bioinformatics studies of the SARS-CoV-2 genome. In this study, we inspected high-frequency mutations of SARS-CoV-2 and carried out systematic analyses of their overlay with inverted repeat (IR) loci and CpG islands. The main conclusion of our study is that SARS-CoV-2 hot-spot mutations are significantly enriched within both IRs and CpG island loci. This points to their role in genomic instability and may predict further mutational drive of the SARS-CoV-2 genome. Moreover, CpG islands are strongly enriched upstream from viral ORFs and thus could play important roles in transcription and the viral life cycle. We hypothesize that hypermethylation of these loci will decrease the transcription of viral ORFs and could therefore limit the progression of the disease.
- MeSH
- COVID-19 virologie MeSH
- CpG ostrůvky * MeSH
- genom virový MeSH
- lidé MeSH
- metylace DNA MeSH
- mutace * MeSH
- SARS-CoV-2 genetika MeSH
- vazba proteinů MeSH
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- lidé MeSH
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- časopisecké články MeSH
- práce podpořená grantem MeSH
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