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CIBER in Epidemiology and Public Heal... 1 Department of Genomics and Health Fou... 1 Department of Genomics and Health Fou... 1 Department of Genomics and Health Fou... 1 Institute for Integrative Systems Bio... 1 Institute of Molecular Biomedicine Fa... 1 Institute of Molecular Biomedicine Fa... 1 Institute of Molecular Biomedicine Fa... 1 School of Dentistry The University of... 1
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CIBER in Epidemiology and Public Heal... 1 Department of Genomics and Health Fou... 1 Department of Genomics and Health Fou... 1 Department of Genomics and Health Fou... 1 Institute for Integrative Systems Bio... 1 Institute of Molecular Biomedicine Fa... 1 Institute of Molecular Biomedicine Fa... 1 Institute of Molecular Biomedicine Fa... 1 School of Dentistry The University of... 1
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Džunková, Mária
Autor Džunková, Mária Department of Genomics and Health, Foundation for the Promotion of Health and Biomedical Research of Valencia Region (FISABIO-Public Health), Valencia, Spain. CIBER in Epidemiology and Public Health (CIBEResp), Madrid, Spain. 3Institute for Integrative Systems Biology (I2SysBio), The University of Valencia and The Spanish National Research Council (CSIC)-UVEG, Valencia, Spain. 4Australian Centre for Ecogenomics, The University of Queensland, St Lucia, QLD Australia
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Martinez-Martinez, Daniel
Autor Martinez-Martinez, Daniel Department of Genomics and Health, Foundation for the Promotion of Health and Biomedical Research of Valencia Region (FISABIO-Public Health), Valencia, Spain. CIBER in Epidemiology and Public Health (CIBEResp), Madrid, Spain. 3Institute for Integrative Systems Biology (I2SysBio), The University of Valencia and The Spanish National Research Council (CSIC)-UVEG, Valencia, Spain
- Gardlík, Roman, 1983-
- Behuliak, Michal
- Janšáková, Katarína
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Jiménez, Nuria
Autor Jiménez, Nuria Department of Genomics and Health, Foundation for the Promotion of Health and Biomedical Research of Valencia Region (FISABIO-Public Health), Valencia, Spain. CIBER in Epidemiology and Public Health (CIBEResp), Madrid, Spain. 3Institute for Integrative Systems Biology (I2SysBio), The University of Valencia and The Spanish National Research Council (CSIC)-UVEG, Valencia, Spain
- Vázquez-Castellanos, Jorge F
- Martí, Jose Manuel
- D'Auria, Giuseppe
- Bandara, H M H N
Nature Open Access od 2015-12-01
PubMed Central od 2015
Europe PubMed Central od 2015
ProQuest Central od 2015-03-01
Open Access Digital Library od 2015-01-01
Open Access Digital Library od 2015-03-25
Health & Medicine (ProQuest) od 2015-03-01
ROAD: Directory of Open Access Scholarly Resources od 2014
PubMed
30510769
DOI
10.1038/s41522-018-0072-3
Knihovny.cz E-zdroje
The term "bacterial dysbiosis" is being used quite extensively in metagenomic studies, however, the identification of harmful bacteria often fails due to large overlap between the bacterial species found in healthy volunteers and patients. We hypothesized that the pathogenic oral bacteria are individual-specific and they correlate with oxidative stress markers in saliva which reflect the inflammatory processes in the oral cavity. Temporally direct and lagged correlations between the markers and bacterial taxa were computed individually for 26 volunteers who provided saliva samples during one month (21.2 ± 2.7 samples/volunteer, 551 samples in total). The volunteers' microbiomes differed significantly by their composition and also by their degree of microbiome temporal variability and oxidative stress markers fluctuation. The results showed that each of the marker-taxa pairs can have negative correlations in some volunteers while positive in others. Streptococcus mutans, which used to be associated with caries before the metagenomics era, had the most prominent correlations with the oxidative stress markers, however, these correlations were not confirmed in all volunteers. The importance of longitudinal samples collections in correlation studies was underlined by simulation of single sample collections in 1000 different combinations which produced contradictory results. In conclusion, the distinct intra-individual correlation patterns suggest that different bacterial consortia might be involved in the oxidative stress induction in each human subject. In the future, decreasing cost of DNA sequencing will allow to analyze multiple samples from each patient, which might help to explore potential diagnostic applications and understand pathogenesis of microbiome-associated oral diseases.
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Po ukončení testovacího provozu bude odkaz přesměrován adresu produkční verze portálu Medvik.