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Autor
Belachew, Alem A 1 Berndt, Sonja I 1 Bhatti, Parveen 1 Brown, Elizabeth E 1 Buda, Gabriele 1 Butrym, Aleksandra 1 Camp, Nicola J 1 Campa, Daniele 1 Canzian, Federico 1 Carvajal-Carmona, Luis G 1 Chanock, Stephen J 1 Clay-Gilmour, Alyssa 1 Cozen, Wendy 1 Dudziński, Marek 1 Försti, Asta 1 Giles, Graham G 1 Goldschmidt, Hartmut 1 Hemminki, Kari 1 Hielscher, Thomas 1 Hildebrandt, Michelle A T 1
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Pracoviště
Biomedical Center Faculty of Medicine... 1 CCU Molecular Hematology Oncology Ger... 1 Cancer Epidemiology Division Cancer C... 1 Centre for Epidemiology and Biostatis... 1 Clinical and Experimental Medicine Se... 1 Community Engagement Program Clinical... 1 Department of Biochemistry and Molecu... 1 Department of Biology University of P... 1 Department of Epidemiology and Biosta... 1 Department of Haematology Rigshospita... 1 Department of Haematology and Bone Ma... 1 Department of Hematology Institute of... 1 Department of Hematology Medical Univ... 1 Department of Hematology Military Ins... 1 Department of Hematology Rydygier Hos... 1 Department of Hematology Specialist H... 1 Department of Hematology Transplantat... 1 Department of Hematology University H... 1 Department of Hematology University H... 1 Department of Hematology and Internal... 1
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Autor
Belachew, Alem A 1 Berndt, Sonja I 1 Bhatti, Parveen 1 Brown, Elizabeth E 1 Buda, Gabriele 1 Butrym, Aleksandra 1 Camp, Nicola J 1 Campa, Daniele 1 Canzian, Federico 1 Carvajal-Carmona, Luis G 1 Chanock, Stephen J 1 Clay-Gilmour, Alyssa 1 Cozen, Wendy 1 Dudziński, Marek 1 Försti, Asta 1 Giles, Graham G 1 Goldschmidt, Hartmut 1 Hemminki, Kari 1 Hielscher, Thomas 1 Hildebrandt, Michelle A T 1
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Pracoviště
Biomedical Center Faculty of Medicine... 1 CCU Molecular Hematology Oncology Ger... 1 Cancer Epidemiology Division Cancer C... 1 Centre for Epidemiology and Biostatis... 1 Clinical and Experimental Medicine Se... 1 Community Engagement Program Clinical... 1 Department of Biochemistry and Molecu... 1 Department of Biology University of P... 1 Department of Epidemiology and Biosta... 1 Department of Haematology Rigshospita... 1 Department of Haematology and Bone Ma... 1 Department of Hematology Institute of... 1 Department of Hematology Medical Univ... 1 Department of Hematology Military Ins... 1 Department of Hematology Rydygier Hos... 1 Department of Hematology Specialist H... 1 Department of Hematology Transplantat... 1 Department of Hematology University H... 1 Department of Hematology University H... 1 Department of Hematology and Internal... 1
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NLK
Free Medical Journals
od 1991 do Před 1 rokem
Freely Accessible Science Journals
od 1991 do Před 12 měsíci
Open Access Digital Library
od 1991-11-01
Open Access Digital Library
od 1991-11-01
PubMed
35700034
DOI
10.1158/1055-9965.epi-22-0043
Knihovny.cz E-zdroje
BACKGROUND: Genome-wide association studies (GWAS) of multiple myeloma in populations of European ancestry (EA) identified and confirmed 24 susceptibility loci. For other cancers (e.g., colorectum and melanoma), risk loci have also been associated with patient survival. METHODS: We explored the possible association of all the known risk variants and their polygenic risk score (PRS) with multiple myeloma overall survival (OS) in multiple populations of EA [the International Multiple Myeloma rESEarch (IMMEnSE) consortium, the International Lymphoma Epidemiology consortium, CoMMpass, and the German GWAS] for a total of 3,748 multiple myeloma cases. Cox proportional hazards regression was used to assess the association between each risk SNP with OS under the allelic and codominant models of inheritance. All analyses were adjusted for age, sex, country of origin (for IMMEnSE) or principal components (for the others) and disease stage (ISS). SNP associations were meta-analyzed. RESULTS: SNP associations were meta-analyzed. From the meta-analysis, two multiple myeloma risk SNPs were associated with OS (P < 0.05), specifically POT1-AS1-rs2170352 [HR = 1.37; 95% confidence interval (CI) = 1.09-1.73; P = 0.007] and TNFRSF13B-rs4273077 (HR = 1.19; 95% CI = 1.01-1.41; P = 0.04). The association between the combined 24 SNP MM-PRS and OS, however, was not significant. CONCLUSIONS: Overall, our results did not support an association between the majority of multiple myeloma risk SNPs and OS. IMPACT: This is the first study to investigate the association between multiple myeloma PRS and OS in multiple myeloma.
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