- Autor
-
Pracoviště
Department of Agricultural Food and Nutritio... 1 Department of Cell Biology and Genetics Pala... 1 Department of Medicine Albert Einstein Colle... 1 Department of Microbiology University of Pen... 1 Department of Pathology Mary H Weiser Food A... 1 Department of Pharmaceutical Sciences Univer... 1 Division of Gastroenterology and Hepatology ... 1 Division of Gastroenterology and Nutrition U... 1 TES Pharma Corso Vannucci Perugia Italy 1 The Center for Clinical Pharmacology Washing... 1 The Department of Biological and Environment... 1
- Formát
- Publikační typ
- Check Tag
- Kategorie
- Jazyk
- Země
- Časopis/zdroj
- Dostupnost
- Vlastník
-
Dvorak, Zdenek
Autor Dvorak, Zdenek Department of Cell Biology and Genetics, Palacký University, Olomouc, Czech Republic (Z.D.) Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania (M.K., M.L.) The Center for Clinical Pharmacology, Washington University in St. Louis and St. Louis College of Pharmacy, St. Louis, Missouri (T.P.B.) Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta (B.P.W.) Department of Pharmaceutical Sciences, University of Perugia, Perugia, Italy (A.G., F.G.) TES Pharma, Corso Vannucci, Perugia, Italy (R.P.) The Department of Biological and Environmental Engineering, Cornell University, Ithaca, New York (J.M.) Division of Gastroenterology and Nutrition, UPMC Presbyterian Hospital, Pittsburgh, Pennsylvania (S.J.O.) Division of Gastroenterology and Hepatology, Department of Medicine, Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (R.B.S.) Department of Pathology, Mary H. Weiser Food Allergy Center, and Rogel Cancer Center, University of Michigan School of Medicine, Ann Arbor, Michigan (C.H.K.) and Department of Medicine, Albert Einstein College of Medicine, Bronx, New York (S.M.)
-
Klapholz, Max
Autor Klapholz, Max Department of Cell Biology and Genetics, Palacký University, Olomouc, Czech Republic (Z.D.) Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania (M.K., M.L.) The Center for Clinical Pharmacology, Washington University in St. Louis and St. Louis College of Pharmacy, St. Louis, Missouri (T.P.B.) Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta (B.P.W.) Department of Pharmaceutical Sciences, University of Perugia, Perugia, Italy (A.G., F.G.) TES Pharma, Corso Vannucci, Perugia, Italy (R.P.) The Department of Biological and Environmental Engineering, Cornell University, Ithaca, New York (J.M.) Division of Gastroenterology and Nutrition, UPMC Presbyterian Hospital, Pittsburgh, Pennsylvania (S.J.O.) Division of Gastroenterology and Hepatology, Department of Medicine, Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (R.B.S.) Department of Pathology, Mary H. Weiser Food Allergy Center, and Rogel Cancer Center, University of Michigan School of Medicine, Ann Arbor, Michigan (C.H.K.) and Department of Medicine, Albert Einstein College of Medicine, Bronx, New York (S.M.)
-
Burris, Thomas P
Autor Burris, Thomas P Department of Cell Biology and Genetics, Palacký University, Olomouc, Czech Republic (Z.D.) Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania (M.K., M.L.) The Center for Clinical Pharmacology, Washington University in St. Louis and St. Louis College of Pharmacy, St. Louis, Missouri (T.P.B.) Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta (B.P.W.) Department of Pharmaceutical Sciences, University of Perugia, Perugia, Italy (A.G., F.G.) TES Pharma, Corso Vannucci, Perugia, Italy (R.P.) The Department of Biological and Environmental Engineering, Cornell University, Ithaca, New York (J.M.) Division of Gastroenterology and Nutrition, UPMC Presbyterian Hospital, Pittsburgh, Pennsylvania (S.J.O.) Division of Gastroenterology and Hepatology, Department of Medicine, Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (R.B.S.) Department of Pathology, Mary H. Weiser Food Allergy Center, and Rogel Cancer Center, University of Michigan School of Medicine, Ann Arbor, Michigan (C.H.K.) and Department of Medicine, Albert Einstein College of Medicine, Bronx, New York (S.M.)
-
Willing, Benjamin P
Autor Willing, Benjamin P Department of Cell Biology and Genetics, Palacký University, Olomouc, Czech Republic (Z.D.) Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania (M.K., M.L.) The Center for Clinical Pharmacology, Washington University in St. Louis and St. Louis College of Pharmacy, St. Louis, Missouri (T.P.B.) Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta (B.P.W.) Department of Pharmaceutical Sciences, University of Perugia, Perugia, Italy (A.G., F.G.) TES Pharma, Corso Vannucci, Perugia, Italy (R.P.) The Department of Biological and Environmental Engineering, Cornell University, Ithaca, New York (J.M.) Division of Gastroenterology and Nutrition, UPMC Presbyterian Hospital, Pittsburgh, Pennsylvania (S.J.O.) Division of Gastroenterology and Hepatology, Department of Medicine, Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (R.B.S.) Department of Pathology, Mary H. Weiser Food Allergy Center, and Rogel Cancer Center, University of Michigan School of Medicine, Ann Arbor, Michigan (C.H.K.) and Department of Medicine, Albert Einstein College of Medicine, Bronx, New York (S.M.)
-
Gioiello, Antimo
Autor Gioiello, Antimo Department of Cell Biology and Genetics, Palacký University, Olomouc, Czech Republic (Z.D.) Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania (M.K., M.L.) The Center for Clinical Pharmacology, Washington University in St. Louis and St. Louis College of Pharmacy, St. Louis, Missouri (T.P.B.) Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta (B.P.W.) Department of Pharmaceutical Sciences, University of Perugia, Perugia, Italy (A.G., F.G.) TES Pharma, Corso Vannucci, Perugia, Italy (R.P.) The Department of Biological and Environmental Engineering, Cornell University, Ithaca, New York (J.M.) Division of Gastroenterology and Nutrition, UPMC Presbyterian Hospital, Pittsburgh, Pennsylvania (S.J.O.) Division of Gastroenterology and Hepatology, Department of Medicine, Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (R.B.S.) Department of Pathology, Mary H. Weiser Food Allergy Center, and Rogel Cancer Center, University of Michigan School of Medicine, Ann Arbor, Michigan (C.H.K.) and Department of Medicine, Albert Einstein College of Medicine, Bronx, New York (S.M.)
-
Pellicciari, Roberto
Autor Pellicciari, Roberto Department of Cell Biology and Genetics, Palacký University, Olomouc, Czech Republic (Z.D.) Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania (M.K., M.L.) The Center for Clinical Pharmacology, Washington University in St. Louis and St. Louis College of Pharmacy, St. Louis, Missouri (T.P.B.) Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta (B.P.W.) Department of Pharmaceutical Sciences, University of Perugia, Perugia, Italy (A.G., F.G.) TES Pharma, Corso Vannucci, Perugia, Italy (R.P.) The Department of Biological and Environmental Engineering, Cornell University, Ithaca, New York (J.M.) Division of Gastroenterology and Nutrition, UPMC Presbyterian Hospital, Pittsburgh, Pennsylvania (S.J.O.) Division of Gastroenterology and Hepatology, Department of Medicine, Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (R.B.S.) Department of Pathology, Mary H. Weiser Food Allergy Center, and Rogel Cancer Center, University of Michigan School of Medicine, Ann Arbor, Michigan (C.H.K.) and Department of Medicine, Albert Einstein College of Medicine, Bronx, New York (S.M.)
-
Galli, Francesco
Autor Galli, Francesco Department of Cell Biology and Genetics, Palacký University, Olomouc, Czech Republic (Z.D.) Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania (M.K., M.L.) The Center for Clinical Pharmacology, Washington University in St. Louis and St. Louis College of Pharmacy, St. Louis, Missouri (T.P.B.) Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta (B.P.W.) Department of Pharmaceutical Sciences, University of Perugia, Perugia, Italy (A.G., F.G.) TES Pharma, Corso Vannucci, Perugia, Italy (R.P.) The Department of Biological and Environmental Engineering, Cornell University, Ithaca, New York (J.M.) Division of Gastroenterology and Nutrition, UPMC Presbyterian Hospital, Pittsburgh, Pennsylvania (S.J.O.) Division of Gastroenterology and Hepatology, Department of Medicine, Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (R.B.S.) Department of Pathology, Mary H. Weiser Food Allergy Center, and Rogel Cancer Center, University of Michigan School of Medicine, Ann Arbor, Michigan (C.H.K.) and Department of Medicine, Albert Einstein College of Medicine, Bronx, New York (S.M.)
-
March, John
Autor March, John Department of Cell Biology and Genetics, Palacký University, Olomouc, Czech Republic (Z.D.) Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania (M.K., M.L.) The Center for Clinical Pharmacology, Washington University in St. Louis and St. Louis College of Pharmacy, St. Louis, Missouri (T.P.B.) Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta (B.P.W.) Department of Pharmaceutical Sciences, University of Perugia, Perugia, Italy (A.G., F.G.) TES Pharma, Corso Vannucci, Perugia, Italy (R.P.) The Department of Biological and Environmental Engineering, Cornell University, Ithaca, New York (J.M.) Division of Gastroenterology and Nutrition, UPMC Presbyterian Hospital, Pittsburgh, Pennsylvania (S.J.O.) Division of Gastroenterology and Hepatology, Department of Medicine, Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (R.B.S.) Department of Pathology, Mary H. Weiser Food Allergy Center, and Rogel Cancer Center, University of Michigan School of Medicine, Ann Arbor, Michigan (C.H.K.) and Department of Medicine, Albert Einstein College of Medicine, Bronx, New York (S.M.)
-
O'Keefe, Stephen J
Autor O'Keefe, Stephen J Department of Cell Biology and Genetics, Palacký University, Olomouc, Czech Republic (Z.D.) Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania (M.K., M.L.) The Center for Clinical Pharmacology, Washington University in St. Louis and St. Louis College of Pharmacy, St. Louis, Missouri (T.P.B.) Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta (B.P.W.) Department of Pharmaceutical Sciences, University of Perugia, Perugia, Italy (A.G., F.G.) TES Pharma, Corso Vannucci, Perugia, Italy (R.P.) The Department of Biological and Environmental Engineering, Cornell University, Ithaca, New York (J.M.) Division of Gastroenterology and Nutrition, UPMC Presbyterian Hospital, Pittsburgh, Pennsylvania (S.J.O.) Division of Gastroenterology and Hepatology, Department of Medicine, Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (R.B.S.) Department of Pathology, Mary H. Weiser Food Allergy Center, and Rogel Cancer Center, University of Michigan School of Medicine, Ann Arbor, Michigan (C.H.K.) and Department of Medicine, Albert Einstein College of Medicine, Bronx, New York (S.M.)
-
Sartor, R Balfour
Autor Sartor, R Balfour Department of Cell Biology and Genetics, Palacký University, Olomouc, Czech Republic (Z.D.) Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania (M.K., M.L.) The Center for Clinical Pharmacology, Washington University in St. Louis and St. Louis College of Pharmacy, St. Louis, Missouri (T.P.B.) Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta (B.P.W.) Department of Pharmaceutical Sciences, University of Perugia, Perugia, Italy (A.G., F.G.) TES Pharma, Corso Vannucci, Perugia, Italy (R.P.) The Department of Biological and Environmental Engineering, Cornell University, Ithaca, New York (J.M.) Division of Gastroenterology and Nutrition, UPMC Presbyterian Hospital, Pittsburgh, Pennsylvania (S.J.O.) Division of Gastroenterology and Hepatology, Department of Medicine, Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (R.B.S.) Department of Pathology, Mary H. Weiser Food Allergy Center, and Rogel Cancer Center, University of Michigan School of Medicine, Ann Arbor, Michigan (C.H.K.) and Department of Medicine, Albert Einstein College of Medicine, Bronx, New York (S.M.) ryan_balfour_sartor@med.unc.edu
NLK
Free Medical Journals
od Před 5 lety do Před 1 rokem
Open Access Digital Library
od 1965-07-01
Open Access Digital Library
od 1997-01-01
PubMed
32764096
DOI
10.1124/molpharm.120.000035
Knihovny.cz E-zdroje
For decades, traditional drug discovery has used natural product and synthetic chemistry approaches to generate libraries of compounds, with some ending as promising drug candidates. A complementary approach has been to adopt the concept of biomimicry of natural products and metabolites so as to improve multiple drug-like features of the parent molecule. In this effort, promiscuous and weak interactions between ligands and receptors are often ignored in a drug discovery process. In this Emerging Concepts article, we highlight microbial metabolite mimicry, whereby parent metabolites have weak interactions with their receptors that then have led to discrete examples of more potent and effective drug-like molecules. We show specific examples of parent-metabolite mimics with potent effects in vitro and in vivo. Furthermore, we show examples of emerging microbial ligand-receptor interactions and provide a context in which these ligands could be improved as potential drugs. A balanced conceptual advance is provided in which we also acknowledge potential pitfalls-hyperstimulation of finely balanced receptor-ligand interactions could also be detrimental. However, with balance, we provide examples of where this emerging concept needs to be tested. SIGNIFICANCE STATEMENT: Microbial metabolite mimicry is a novel way to expand on the chemical repertoire of future drugs. The emerging concept is now explained using specific examples of the discovery of therapeutic leads from microbial metabolites.
- MeSH
- Bacteria chemie MeSH
- biologické přípravky chemie MeSH
- indoly chemie farmakologie MeSH
- lidé MeSH
- ligandy MeSH
- molekulární mimikry MeSH
- objevování léků MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
- Research Support, U.S. Gov't, Non-P.H.S. MeSH
Upřesnit dle MeSH
Sdílet
Název dokumentu
Po ukončení testovacího provozu bude odkaz přesměrován adresu produkční verze portálu Medvik.