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1st Department of Neurology Faculty o... 1 Department of ENT and HNS Faculty of ... 1 Department of Neurology General Hospi... 1 Department of Neurology University Ho... 1 Department of Otorhinolaryngology Uni... 1 Department of Pediatric Otorhinolaryn... 1 Faculty of Medicine Masaryk Universit... 1 Institute of Cancer and Genomic Scien... 1 Institute of Medical Chemistry Bioche... 1
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1st Department of Neurology Faculty o... 1 Department of ENT and HNS Faculty of ... 1 Department of Neurology General Hospi... 1 Department of Neurology University Ho... 1 Department of Otorhinolaryngology Uni... 1 Department of Pediatric Otorhinolaryn... 1 Faculty of Medicine Masaryk Universit... 1 Institute of Cancer and Genomic Scien... 1 Institute of Medical Chemistry Bioche... 1
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NLK
Directory of Open Access Journals
od 2011
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od 2011
PubMed Central
od 2011
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PubMed
36836798
DOI
10.3390/life13020441
Knihovny.cz E-zdroje
BACKGROUND: Obstructive sleep apnea (OSA) activates several pathophysiological mechanisms which can lead to the development of vascular diseases. Endothelial dysfunction (ED) is an initial step in the development of atherosclerosis. The association between ED and OSA has been described in several studies, even in previously healthy subjects. High-density lipoproteins (HDL) were generally considered to be atheroprotective, and low-density lipoprotein (LDL) to be an atherogenic component of lipoproteins. However, recent findings suggest a pro-atherogenic role of small HDL subfractions (8-10) and LDL subfractions (3-7). This study aimed to evaluate the relationship between endothelial function and lipid subfractions in previously healthy OSA subjects. MATERIAL AND METHODS: We prospectively enrolled 205 subjects with sleep monitoring. Plasma levels of triacylglycerols, total cholesterol, LDL, HDL, and their subfractions were assessed. Endothelial function was determined using peripheral arterial tonometry, and reperfusion hyperemia index (RHI) was assessed. RESULTS: Plasma levels of small and intermediate HDL subfractions have statistically significant pro-atherogenic correlations with endothelial function (p = 0.015 and p = 0.019). In other lipoprotein levels, no other significant correlation was found with RHI. In stepwise multiple linear regression analysis, small HDL (beta = -0.507, p = 0.032) was the only significant contributor in the model predicting RHI. CONCLUSIONS: In our studied sample, a pro-atherogenic role of small HDL subfractions in previously healthy subjects with moderate-to-severe OSA was proven.
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Po ukončení testovacího provozu bude odkaz přesměrován adresu produkční verze portálu Medvik.