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4th Internal Haematology Department C... 1 Central European Institute of Technol... 1 Clinic of Maxillofacial Surgery Insti... 1 Clinic of Stomatology Faculty of Medi... 1 Department of Burns and Plastic Surge... 1 Department of Burns and Reconstructiv... 1 Department of Burns and Reconstructiv... 1 Department of Clinical Microbiology U... 1 Department of Dermatovenerology Charl... 1 Department of Military Surgery Facult... 1 Department of Molecular Pharmacy Facu... 1 Department of Paediatrics Charles Uni... 1 Department of Pathophysiology Faculty... 1 Division of Plastic Surgery and Burns... 1 Institute of Biostatistics and Analys... 1 Institute of Medical Genetics and Gen... 1 Prague Burn Center Charles University... 1
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4th Internal Haematology Department C... 1 Central European Institute of Technol... 1 Clinic of Maxillofacial Surgery Insti... 1 Clinic of Stomatology Faculty of Medi... 1 Department of Burns and Plastic Surge... 1 Department of Burns and Reconstructiv... 1 Department of Burns and Reconstructiv... 1 Department of Clinical Microbiology U... 1 Department of Dermatovenerology Charl... 1 Department of Military Surgery Facult... 1 Department of Molecular Pharmacy Facu... 1 Department of Paediatrics Charles Uni... 1 Department of Pathophysiology Faculty... 1 Division of Plastic Surgery and Burns... 1 Institute of Biostatistics and Analys... 1 Institute of Medical Genetics and Gen... 1 Prague Burn Center Charles University... 1
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Lipovy, Bretislav
Autor Lipovy, Bretislav Department of Burns and Plastic Surgery, Institution Shared with the University Hospital Brno, Faculty of Medicine, Masaryk University, Kamenice 753/5, 625 00 Brno, Czech Republic Central European Institute of Technology, Brno University of Technology, Purkyňova 656/123, 612 00 Brno, Czech Republic
- Holoubek, Jakub
- Hanslianova, Marketa
- Cvanova, Michaela
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Klein, Leo
Autor Klein, Leo Division of Plastic Surgery and Burns Treatment, Department of Surgery, Charles Univesrity, Faculty of Medicine and Teaching Hospital, Sokolská 581, 500 05 Hradec Králové, Czech Republic Department of Military Surgery, Faculty of Military Health Sciences, University of Defence, Třebešská 1575, 500 01 Hradec Králové, Czech Republic
- Grossova, Ivana
- Zajicek, Robert
- Bukovcan, Peter
- Koller, Jan
- Baran, Matus
NLK
Directory of Open Access Journals
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PubMed Central
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ROAD: Directory of Open Access Scholarly Resources
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PubMed
33477980
DOI
10.3390/microorganisms9010202
Knihovny.cz E-zdroje
Toxic epidermal necrolysis (TEN) is a rare disease, which predominantly manifests as damage to the skin and mucosa. Antibiotics count among the most common triggers of this hypersensitive reaction. Patients with TEN are highly susceptible to infectious complications due to the loss of protective barriers and immunosuppressant therapy. The aim of this study was to investigate the potential relationship between antibiotics used before the development of TEN and early and late-onset infectious complications in TEN patients. In this European multicentric retrospective study (Central European Lyell syndrome: therapeutic evaluation (CELESTE)), records showed that 18 patients with TEN used antibiotics (mostly aminopenicillins) before the disease development (group 1), while in 21 patients, TEN was triggered by another factor (group 2). The incidence of late-onset infectious complications (5 or more days after the transfer to the hospital) caused by Gram-positive bacteria (especially by Enterococcus faecalis/faecium) was significantly higher in group 1 than in group 2 (82.4% vs. 35.0%, p = 0.007/pcorr = 0.014) while no statistically significant difference was observed between groups of patients with infection caused by Gram-negative bacteria, yeasts, and filamentous fungi (p > 0.05). Patients with post-antibiotic development of TEN are critically predisposed to late-onset infectious complications caused by Gram-positive bacteria, which may result from the dissemination of these bacteria from the primary focus.
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Po ukončení testovacího provozu bude odkaz přesměrován adresu produkční verze portálu Medvik.