- Bildziukevich, Uladzimir
- Özdemir, Zulal
- Šaman, David
- Vlk, Martin
- Šlouf, Miroslav
- Rárová, Lucie
-
Wimmer, Zdeněk
Autor Wimmer, Zdeněk ORCID Institute of Experimental Botany of the Czech Academy of Sciences, Isotope Laboratory, Vídeňská 1083, CZ-14220 Prague 4, Czech Republic. wimmerz@vscht.cz University of Chemistry and Technology in Prague, Department of Chemistry of Natural Compounds, Technická 5, CZ-16628 Prague 6, Czech Republic
PubMed
36222062
DOI
10.1039/d2ob01172g
Knihovny.cz E-zdroje
1,10-Phenanthroline was decorated with triterpenoid-based substituents bearing additional spermine units to form amphiphilic molecules. The synthetic procedure designed for the new phenanthroline-triterpenoid amphiphiles is described in detail. Besides 1,10-phenanthroline, all target structures bear 1,4-disubstituted 1,2,3-triazole rings. The target compounds self-assembled into either helical-like or sheet-like nanostructures, depending on the structure of the target molecule, either based on betulinic acid or oleanolic acid, and on the way of binding spermine subunits to the rest of the molecules. They also proved their ability to coordinate 64Cu(II) ions. Finally, the target compounds showed cytotoxicity that was partly dependent on the formation of nanostructures.
- MeSH
- fenantroliny chemie MeSH
- kyselina olenalová * MeSH
- spermin MeSH
- triazoly MeSH
- triterpeny * MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
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