- Autor
-
Pracoviště
Cancer Research Czech Republic Olomou... 1 Department of Surgery Faculty of Medi... 1 Department of Surgery Tomas Bata Regi... 1 Department of Thoracic Surgery Clinic... 1 Faculty of Healthcare Alexander Dubce... 1 Institute of Molecular and Clinical P... 1 Laboratory of Experimental Medicine I... 1 Laboratory of Experimental Medicine U... 1
- Formát
- Publikační typ
- Kategorie
- Jazyk
- Země
- Časopis/zdroj
- Dostupnost
- Vlastník
- Autor
-
Pracoviště
Cancer Research Czech Republic Olomou... 1 Department of Surgery Faculty of Medi... 1 Department of Surgery Tomas Bata Regi... 1 Department of Thoracic Surgery Clinic... 1 Faculty of Healthcare Alexander Dubce... 1 Institute of Molecular and Clinical P... 1 Laboratory of Experimental Medicine I... 1 Laboratory of Experimental Medicine U... 1
- Formát
- Publikační typ
- Kategorie
- Jazyk
- Země
- Časopis/zdroj
- Dostupnost
- Vlastník
-
Rehulkova, Alona
Autor Rehulkova, Alona Laboratory of Experimental Medicine, Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Czech Advanced Technology and Research Institute, Palacky University in Olomouc, Olomouc, Czech Republic Laboratory of Experimental Medicine, University Hospital in Olomouc, Olomouc, Czech Republic Department of Surgery, Faculty of Medicine and Dentistry, Palacky University and University Hospital in Olomouc, Olomouc, Czech Republic Department of Surgery, Tomas Bata Regional Hospital, Zlin, Czech Republic
- Chudacek, Josef
- Prokopova, Andrea
- Vidlarova, Monika
-
Stranska, Jana
Autor Stranska, Jana Laboratory of Experimental Medicine, Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Czech Advanced Technology and Research Institute, Palacky University in Olomouc, Olomouc, Czech Republic Laboratory of Experimental Medicine, University Hospital in Olomouc, Olomouc, Czech Republic
-
Drabek, Jiri
Autor Drabek, Jiri Laboratory of Experimental Medicine, Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Czech Advanced Technology and Research Institute, Palacky University in Olomouc, Olomouc, Czech Republic Laboratory of Experimental Medicine, University Hospital in Olomouc, Olomouc, Czech Republic
- Potockova, Jana
- Trojanec, Radek
- Vrbková, Jana, 1971-
- Skarda, Josef
PubMed Central od 2012
Europe PubMed Central od 2012
PubMed
37323172
DOI
10.21037/tlcr-22-801
Knihovny.cz E-zdroje
BACKGROUND: Surgical treatment of early-stage non-small cell lung cancer (NSCLC) yields highest expectations for recovery. However, the frequency of further disease progression remains high since micro-metastatic disease may be undetected by conventional diagnostic methods. We test the presence and prognostic impact of circulating tumor cells (CTCs) in peripheral blood (PB), tumor-draining pulmonary blood (TDB) and bone marrow (BM) samples from NSCLC patients. METHODS: The presence of circulating/disseminated tumor cells (CTCs/DTCs) was detected by quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) analysis in PB, TDB and BM samples before surgery in 119 stage IA-IIIA NSCLC patients (Clinical Trial NS10285). RESULTS: NSCLC patients with the presence of carcinoembryonic antigen (CEA) mRNA-positive CTCs/DTCs in TDB and BM had significantly shorter cancer-specific survival (CSS) (P<0.013, resp. P<0.038). Patients with the presence of epithelial cellular adhesion molecule (EpCAM) mRNA-positive CTCs in TDB samples had significantly shorter CSS and disease-free survival (DFS) (P<0.031, resp. P<0.045). A multivariate analysis identified the presence of CEA mRNA-positive CTCs in the PB as an independent negative prognostic factor for DFS (P<0.005). No significant correlation of CTCs/DTCs presence and other prognostic factors was found. CONCLUSIONS: In NSCLC patients undergoing radical surgery, the presence of CEA and EpCAM mRNA-positive CTCs/DTCs is associated with poorer survival.
- Publikační typ
- časopisecké články MeSH
Upřesnit dle MeSH
Sdílet
Název dokumentu
Po ukončení testovacího provozu bude odkaz přesměrován adresu produkční verze portálu Medvik.