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Autor
Alfaro, Enrique 1 Boltin, Doron 1 Bordin, Dmitry S 1 Boyanova, Lyudmila 1 Bujanda, Luis 1 Cano-Català, Anna 1 Capelle, Lisette G 1 Dobru, Daniela 1 Doulberis, Michael 1 Fiorini, Giulia 1 Gasbarrini, Antonio 1 Gisbert, Javier P 1 Gridnyev, Oleksiy 1 Hernández, Luis 1 Jonaitis, Laimas 1 Kunovsky, Lumir 1 Kupcinskas, Juozas 1 Lamy, Vincent 1 Lanas, Ángel 1 Leja, Mārcis 1
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Pracoviště
Adelson Faculty of Medicine Ariel Uni... 1 Cardiovascular Internal Medicine IRCC... 1 Center for Research in Health Technol... 1 Centro de Investigación Biomédica en ... 1 Consejo Nacional de Investigaciones C... 1 Departamento de Medicina Universidad ... 1 Department of Digestive Disorders Abe... 1 Department of Gastroenterology Biodon... 1 Department of Gastroenterology DC Rog... 1 Department of Gastroenterology Digest... 1 Department of Gastroenterology HC Int... 1 Department of Gastroenterology Hepato... 1 Department of Gastroenterology Hospit... 1 Department of Gastroenterology Pomera... 1 Department of Gastroenterology Univer... 1 Department of Gastroenterology Univer... 1 Department of Gastroenterology Univer... 1 Department of Gastroenterology Univer... 1 Department of Gastroenterology and Di... 1 Department of Gastroenterology and He... 1
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Autor
Alfaro, Enrique 1 Boltin, Doron 1 Bordin, Dmitry S 1 Boyanova, Lyudmila 1 Bujanda, Luis 1 Cano-Català, Anna 1 Capelle, Lisette G 1 Dobru, Daniela 1 Doulberis, Michael 1 Fiorini, Giulia 1 Gasbarrini, Antonio 1 Gisbert, Javier P 1 Gridnyev, Oleksiy 1 Hernández, Luis 1 Jonaitis, Laimas 1 Kunovsky, Lumir 1 Kupcinskas, Juozas 1 Lamy, Vincent 1 Lanas, Ángel 1 Leja, Mārcis 1
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Pracoviště
Adelson Faculty of Medicine Ariel Uni... 1 Cardiovascular Internal Medicine IRCC... 1 Center for Research in Health Technol... 1 Centro de Investigación Biomédica en ... 1 Consejo Nacional de Investigaciones C... 1 Departamento de Medicina Universidad ... 1 Department of Digestive Disorders Abe... 1 Department of Gastroenterology Biodon... 1 Department of Gastroenterology DC Rog... 1 Department of Gastroenterology Digest... 1 Department of Gastroenterology HC Int... 1 Department of Gastroenterology Hepato... 1 Department of Gastroenterology Hospit... 1 Department of Gastroenterology Pomera... 1 Department of Gastroenterology Univer... 1 Department of Gastroenterology Univer... 1 Department of Gastroenterology Univer... 1 Department of Gastroenterology Univer... 1 Department of Gastroenterology and Di... 1 Department of Gastroenterology and He... 1
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Nyssen, Olga P
Autor Nyssen, Olga P ORCID Digestive System Service of the Hospital Universitario de La Princesa, 28006 Madrid, Spain Instituto de Investigación Sanitaria Princesa (IIS-Princesa), 28006 Madrid, Spain Departamento de Medicina, Universidad Autónoma de Madrid (UAM), 28049 Madrid, Spain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), 28029 Madrid, Spain
- Pratesi, Pietro
- Spínola, Miguel A
- Jonaitis, Laimas
- Pérez-Aísa, Ángeles
- Vaira, Dino
- Saracino, Ilaria Maria
- Pavoni, Matteo
- Fiorini, Giulia
- Tepes, Bojan
PubMed Central od 2012
Europe PubMed Central od 2012
ProQuest Central od 2012-01-01
Open Access Digital Library od 2012-01-01
Open Access Digital Library od 2012-01-01
ROAD: Directory of Open Access Scholarly Resources od 2012
PubMed
37760723
DOI
10.3390/antibiotics12091427
Knihovny.cz E-zdroje
The segmentation of patients into homogeneous groups could help to improve eradication therapy effectiveness. Our aim was to determine the most important treatment strategies used in Europe, to evaluate first-line treatment effectiveness according to year and country. Data collection: All first-line empirical treatments registered at AEGREDCap in the European Registry on Helicobacter pylori management (Hp-EuReg) from June 2013 to November 2022. A Boruta method determined the "most important" variables related to treatment effectiveness. Data clustering was performed through multi-correspondence analysis of the resulting six most important variables for every year in the 2013-2022 period. Based on 35,852 patients, the average overall treatment effectiveness increased from 87% in 2013 to 93% in 2022. The lowest effectiveness (80%) was obtained in 2016 in cluster #3 encompassing Slovenia, Lithuania, Latvia, and Russia, treated with 7-day triple therapy with amoxicillin-clarithromycin (92% of cases). The highest effectiveness (95%) was achieved in 2022, mostly in Spain (81%), with the bismuth-quadruple therapy, including the single-capsule (64%) and the concomitant treatment with clarithromycin-amoxicillin-metronidazole/tinidazole (34%) with 10 (69%) and 14 (32%) days. Cluster analysis allowed for the identification of patients in homogeneous treatment groups assessing the effectiveness of different first-line treatments depending on therapy scheme, adherence, country, and prescription year.
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