- MeSH
- dorostové lékařství MeSH
- kongresy jako téma MeSH
- Publikační typ
- zprávy MeSH
Úvod: Infekcia ľudskými papilomavírusmi (HPV) je najčastejším pohlavne prenosným ochorením u ľudí. Je asociovaná s rozvojom viacerých benígnych, ako aj malígnych stavov a chorôb. Vzhľadom na dokázaný onkogénny potenciál patrí HPV medzi závažné ľudské patogény. V súčasnosti existujú účinné možnosti prevencie HPV infekcie a jej následkov – očkovanie, ktoré je určené nielen pre ženy, ale aj pre mužov. Materiál a metódy: Cieľom našej práce bolo vyhodnotiť údaje týkajúce sa informovanosti o možnostiach očkovania proti infekcii HPV, získané dotazníkovou metódou na vzorke 432 adolescentiek (16,21 ± 1,7 roka). Štúdia bola realizovaná v rokoch 2010 a 2011 na ôsmich stredných školách na Slovensku. Respondentky odpovedali na tri základné otázky týkajúce sa HPV infekcie a možnosti jej prevencie očkovaním. Výsledky: Väčšina respondentiek (93,98 %) bola oboznámená s možnosťou očkovania proti HPV, pričom najčastejším zdrojom informácií boli médiá a lekár gynekológ (spolu 81 %). Napriek dobrej informovanosti o tejto problematike bolo zaočkovaných len 5,79 % dievčat. Záver: Napriek dokázanému preventívnemu účinku, ako aj výbornému bezpečnostnému profilu vakcín proti HPV je preočkovanosť na Slovensku stále nízka. Vzhľadom na najlepšiu účinnosť očkovania pri jeho realizácii v prepubertálnom období, kľúčovú úlohu v jeho odporúčaní zohrávajú všeobecní lekári pre deti a dorast. Nemenej dôležitými sú však aj lekári špecialisti, ktorí sa stretávajú s ochoreniami asociovanými s HPV. Svojím potenciálom zabrániť vzniku rôznych nádorových ochorení predstavuje očkovanie proti HPV jeden z najvýznamnejších objavov modernej preventívnej medicíny.
Introduction: Human papillomavirus (HPV) infection is the most common sexually transmitted human diseases and is associated with the development of several benign and malign conditions and diseases. Regarding its proven oncogenic potential, HPV belongs to the important human pathogens. Today vaccination represents an effective possibility of HPV infection and is not dedicated only to women but also to men. Material and methods: The aim of our survey was the evaluation of the data regarding the knowledge about the possibility of vaccination against HPV in the cohort of 432 adolescent girls (aged 16.21 ± 1.7 years) using the questionnaire. The study was performed in the period 2010 – 2011. Participants responded to the three basic questions about HPV infection and the possibility of prevention through the vaccination. Results: The majority of the respondents (93.98 %) were already familiar with the possibility of vaccination against HPV and the most frequent source of information was media and gynaecologists (together 81 %). Despite the good awareness of this topic, only 5.79 % of the girls were already vaccinated. Conclusions: Despite already proven preventive effect and excellent safety profile of the vaccines against HPV, the vaccination rate is still very low in the Slovak population. Regarding the better vaccine efficacy in its timing in the prepubertal age, the key role in vaccination recommendation and realization play general practitioners for children and adolescents. However, also other physicians and general practitioners for adults, who also take care about the patients with HPV-associated conditions, are not less important. Vaccination against HPV represents one of the most important inventions of modern preventive medicine due to its capacity to prevent the development of various oncologic diseases.
Introduction: Human papillomavirus (HPV) infection is associated with the development of several benign and malign conditions and diseases. Regarding its proven oncogenic potential, HPV belongs to the important human pathogens. Today, vaccination represents an effective possibility of HPV infection and is not dedicated only for women but also for men. Material and methods: The aim of our survey was the evaluation of the data regarding the knowledge about the possibility of vaccination against HPV in the cohort of 432 adolescent girls (aged 16.21 ± 1.7 years) by using the questionnaire. The study was performed in the period 2010 - 2011. Participants responded to the three basic questions about HPV infection and the possibility of prevention through the vaccination. Results: The majority of the respondents (93.98 %) were already familiar with the possibility of vaccination against HPV and the most frequent source of information were media and gynaecologists (together 81 %). Despite the good awareness about this topic, only 5.79 % of the girls were already vaccinated. Conclusions: Despite already proven preventive effect and excellent safety profile of the vaccines against HPV, the vaccination rate is still very low in the population of Slovakia. Regarding the better vaccine efficacy in its timing in the prepubertal age, the key role in vaccination recommendation and realization play general practitioners for children and adolescents. However, also other physicians and general practitioners for adults, who also take care about the patients with HPV-associated conditions, are not less important. Vaccination against HPV represents one of the most important inventions of modern preventive medicine due to its capacity to prevent the development of various oncologic diseases.
Introduction: Human papillomavirus (HPV) infection is associated with the development of several benign and malign conditions and diseases. Regarding its proven oncogenic potential, HPV belongs to the important human pathogens. Today, vaccination represents an effective possibility of HPV infection and is not dedicated only for women but also for men. Material and methods: The aim of our survey was the evaluation of the data regarding the knowledge about the possibility of vaccination against HPV in the cohort of 432 adolescent girls (aged 16.21 ± 1.7 years) by using the questionnaire. The study was performed in the period 2010 - 2011. Participants responded to the three basic questions about HPV infection and the possibility of prevention through the vaccination. Results: The majority of the respondents (93.98 %) were already familiar with the possibility of vaccination against HPV and the most frequent source of information were media and gynaecologists (together 81 %). Despite the good awareness about this topic, only 5.79 % of the girls were already vaccinated. Conclusions: Despite already proven preventive effect and excellent safety profile of the vaccines against HPV, the vaccination rate is still very low in the population of Slovakia. Regarding the better vaccine efficacy in its timing in the prepubertal age, the key role in vaccination recommendation and realization play general practitioners for children and adolescents. However, also other physicians and general practitioners for adults, who also take care about the patients with HPV-associated conditions, are not less important. Vaccination against HPV represents one of the most important inventions of modern preventive medicine due to its capacity to prevent the development of various oncologic diseases.
Cieľ: Včasná diagnostika a liečba infekcie horných močových ciest je v detskom veku náročná a veľmi dôležitá vzhľadom na prognózu ochorenia. Cieľom našej práce bolo overiť možnosti využitia merania indexu rezistencie počas akútnej pyelonefritídy pri diagnostike ochorenia a pri určovaní rozsahu postihnutia obličiek. Metódy: Do súboru bolo zaradených 53 detí (43 dievčat, 10 chlapcov) vo veku 0-19 rokov s prvým atakom akútnej pyelonefritídy. Pacienti boli rozdelení do troch vekových skupín - deti do 4 rokov, od 4 do 7 rokov a deti nad 7 rokov a porovnávali sa so skupinou 29 detí bez príznakov akútnej infekcie a s normálnou funkciou obličiek. U 37 detí sme urobili analýzu rozsahu postihnutia zápalovým procesom. U všetkých pacientov bolo realizované ultrasonografické vyšetrenie uropoetického traktu do 72 hodín od začiatku hospitalizácie zamerané na morfológiu obličiek a meranie indexu rezistencie (RI) prostredníctvom dopplerovskej sonografie. Vo všetkých troch vekových kategóriách boli zistené signifikantne vyššie hodnoty RI pri zápalom postihnutých obličkách oproti obličkám kontrolnej skupiny. Výsledky: U 24 detí (64,8 %) išlo o unilaterálny zápalový proces a u 13 detí (35,2 %) išlo o proces bilaterálny. Záver: Na základe výsledkov možno skonštatovať, že meranie RI má výrazný prínos v diagnostike nejednoznačných prípadov akútnej pyelonefritídy, ako aj v možnosti určenia rozsahu postihnutia obličiek a možno ho odporučiť ako diagnostický postup doplňujúci štandardné diagnostické metodiky.
Aim: Early diagnosis and treatment of infections of the upper urinary tract in children is difficult and very important with regard to the prognosis of the disease. The aim of our study was to verify the possibility of using measurements of resistivity index during acute pyelonephritis in the diagnosis of disease and to determine the extent of renal involvement. Methods: 53 children were eligible in the group (43 girls, 10 boys) at the age of 0-19 years at the first attack of acute pyelonephritis. The patients were divided into three age groups - children up to 4 years, 4 to 7 years and children older than 7 years and they were compared with a group of 29 children without symptoms of acute infection and normal kidney function. Ultrasonography examination of uropoietic tract oriented to kidney morphology was performed in all patients up to 72 hours from the beginning of hospitaliza-tion and RI was measured by beans of Doppler sonography In all the three age categories the authors detected significantly higher values of RI in kidneys affected by inflammation as compared with kidneys of the control group. Results: In 24 children (64.8%) was a unilateral inflammatory process and in 13 children (35.2%) was a bilateral process. Conclusion: Based on the results it may be concluded that the measurement of RI has significant benefits in the diagnosis of equivocal cases of acute pyelonephritis, as well as the possibility of determining the extent of renal involvement and can be recommended as a complementary diagnostic procedure.
- Klíčová slova
- bilaterální pyelonefritida, unilaterální pyelonefritida,
- MeSH
- akutní nemoc MeSH
- analýza moči MeSH
- biochemická analýza krve MeSH
- cévní rezistence MeSH
- dítě MeSH
- kojenec MeSH
- ledviny patofyziologie ultrasonografie MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- novorozenec MeSH
- předškolní dítě MeSH
- pyelonefritida * diagnóza krev moč patofyziologie MeSH
- ultrasonografie dopplerovská MeSH
- Check Tag
- dítě MeSH
- kojenec MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- novorozenec MeSH
- předškolní dítě MeSH
- ženské pohlaví MeSH
Interleukin-10 (IL-10) is a potent inhibitor of leukocyte chemotaxis, bacterial killing in phagocytes and synthesis of pro-inflammatory cytokines and chemokines, and recent studies have suggested an important role for this immunoregulatory cytokine in the pathogenesis of urinary tract infections (UTIs). Therefore, the gene encoding IL-10 (IL10) is an attractive candidate for association studies attempting to identify susceptibility genes conferring risk of UTIs. In this case-control study, we aimed to investigate the association of single nucleotide polymorphisms (SNPs) in the promoter region of IL10 with acute pyelonephritis in the Slovak population. Polymerase chain reaction with sequence-specific primers was used to analyse IL10 -1082A/G (rs1800896), -819C/T (rs1800871) and -592C/A (rs1800872) SNPs in 147 children with acute pyelonephritis and 215 healthy controls. Comparison of patients with healthy controls using the logistic regression analysis revealed significantly increased risk of developing recurrent attacks of acute pyelonephritis for -1082 G allele in a dominant genetic model GG (GG + AG vs. AA, P = 0.019, odds ratio (OR) = 2.26). A similar tendency was also found when the recurrent acute pyelonephritis subgroup was compared to episodic pyelonephritis cases (GG + AG vs. AA, P = 0.009, OR = 3.38). In conclusion, our results suggest that IL10 -1082 A/G SNP is a susceptibility factor for development of recurrent attacks of acute pyelonephritis.
- MeSH
- alely MeSH
- dítě MeSH
- DNA chemie genetika MeSH
- dospělí MeSH
- genetická predispozice k nemoci MeSH
- genetická variace MeSH
- interleukin-10 genetika MeSH
- jednonukleotidový polymorfismus MeSH
- lidé středního věku MeSH
- lidé MeSH
- logistické modely MeSH
- mladiství MeSH
- mladý dospělý MeSH
- polymerázová řetězová reakce MeSH
- předškolní dítě MeSH
- promotorové oblasti (genetika) MeSH
- pyelonefritida genetika MeSH
- studie případů a kontrol MeSH
- Check Tag
- dítě MeSH
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- předškolní dítě MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Slovenská republika MeSH
Úvod: Infekcia ľudskými papilomavírusmi (HPV) je najčastejším pohlavne prenosným ochorením u ľudí. Je asociovaná s rozvojom viacerých benígnych, ako aj malígnych stavov a chorôb. Vzhľadom na dokázaný onkogénny potenciál patrí HPV medzi závažné ľudské patogény. V súčasnosti existujú účinné možnosti prevencie HPV infekcie a jej následkov – očkovanie, ktoré je určené nielen pre ženy, ale aj pre mužov. Materiál a metódy: Cieľom našej práce bolo vyhodnotiť údaje týkajúce sa informovanosti o možnostiach očkovania proti infekcii HPV, získané dotazníkovou metódou na vzorke 432 adolescentiek (16,21 ± 1,7 roka). Štúdia bola realizovaná v rokoch 2010 a 2011 na ôsmich stredných školách na Slovensku. Respondentky odpovedali na tri základné otázky týkajúce sa HPV infekcie a možnosti jej prevencie očkovaním. Výsledky: Väčšina respondentiek (93,98 %) bola oboznámená s možnosťou očkovania proti HPV, pričom najčastejším zdrojom informácií boli médiá a lekár gynekológ (spolu 81 %). Napriek dobrej informovanosti o tejto problematike bolo zaočkovaných len 5,79 % dievčat. Záver: Napriek dokázanému preventívnemu účinku, ako aj výbornému bezpečnostnému profilu vakcín proti HPV je preočkovanosť na Slovensku stále nízka. Vzhľadom na najlepšiu účinnosť očkovania pri jeho realizácii v prepubertálnom období, kľúčovú úlohu v jeho odporúčaní zohrávajú všeobecní lekári pre deti a dorast. Nemenej dôležitými sú však aj lekári špecialisti, ktorí sa stretávajú s ochoreniami asociovanými s HPV. Svojím potenciálom zabrániť vzniku rôznych nádorových ochorení predstavuje očkovanie proti HPV jeden z najvýznamnejších objavov modernej preventívnej medicíny.
Introduction: Human papillomavirus (HPV) infection is the most common sexually transmitted human diseases and is associated with the development of several benign and malign conditions and diseases. Regarding its proven oncogenic potential, HPV belongs to the important human pathogens. Today vaccination represents an effective possibility of HPV infection and is not dedicated only to women but also to men. Material and methods: The aim of our survey was the evaluation of the data regarding the knowledge about the possibility of vaccination against HPV in the cohort of 432 adolescent girls (aged 16.21 ± 1.7 years) using the questionnaire. The study was performed in the period 2010 – 2011. Participants responded to the three basic questions about HPV infection and the possibility of prevention through the vaccination. Results: The majority of the respondents (93.98 %) were already familiar with the possibility of vaccination against HPV and the most frequent source of information was media and gynaecologists (together 81 %). Despite the good awareness of this topic, only 5.79 % of the girls were already vaccinated. Conclusions: Despite already proven preventive effect and excellent safety profile of the vaccines against HPV, the vaccination rate is still very low in the Slovak population. Regarding the better vaccine efficacy in its timing in the prepubertal age, the key role in vaccination recommendation and realization play general practitioners for children and adolescents. However, also other physicians and general practitioners for adults, who also take care about the patients with HPV-associated conditions, are not less important. Vaccination against HPV represents one of the most important inventions of modern preventive medicine due to its capacity to prevent the development of various oncologic diseases.
- Publikační typ
- abstrakt z konference MeSH
- Publikační typ
- abstrakt z konference MeSH
