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Autor
Blennow, Kaj 1 Boonkamp, Lynn 1 Fialova, Lubica 1 Hanes, Jozef 1 Hansson, Oskar 1 Hort, Jakub 1 Katina, Stanislav 1 Kontsekova, Eva 1 Kovac, Andrej 1 Kovacech, Branislav 1 Kvartsberg, Hlin 1 Novak, Michal 1 Scheltens, Philip 1 Stevens, Eva 1 Teunissen, Charlotte E 1 Vyhnalek, Martin 1 Zetterberg, Henrik 1 Zilka, Norbert 1
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Pracoviště
AXON Neuroscience CRM Services SE Bra... 1 Axon Neuroscience SE Larnaca Cyprus 1 Clinical Memory Research Unit Departm... 1 Clinical Neurochemistry Laboratory Sa... 1 Department of Clinical Chemistry Neur... 1 Department of Neurodegenerative Disea... 1 Department of Neurology Alzheimer Cen... 1 Department of Psychiatry and Neuroche... 1 From the AXON Neuroscience R and D Se... 1 International Clinical Research Centr... 1 Memory Clinic Department of Neurology... 1 Memory Clinic Skåne University Hospit... 1 UK Dementia Research Institute at UCL... 1
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Autor
Blennow, Kaj 1 Boonkamp, Lynn 1 Fialova, Lubica 1 Hanes, Jozef 1 Hansson, Oskar 1 Hort, Jakub 1 Katina, Stanislav 1 Kontsekova, Eva 1 Kovac, Andrej 1 Kovacech, Branislav 1 Kvartsberg, Hlin 1 Novak, Michal 1 Scheltens, Philip 1 Stevens, Eva 1 Teunissen, Charlotte E 1 Vyhnalek, Martin 1 Zetterberg, Henrik 1 Zilka, Norbert 1
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Pracoviště
AXON Neuroscience CRM Services SE Bra... 1 Axon Neuroscience SE Larnaca Cyprus 1 Clinical Memory Research Unit Departm... 1 Clinical Neurochemistry Laboratory Sa... 1 Department of Clinical Chemistry Neur... 1 Department of Neurodegenerative Disea... 1 Department of Neurology Alzheimer Cen... 1 Department of Psychiatry and Neuroche... 1 From the AXON Neuroscience R and D Se... 1 International Clinical Research Centr... 1 Memory Clinic Department of Neurology... 1 Memory Clinic Skåne University Hospit... 1 UK Dementia Research Institute at UCL... 1
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Hanes, Jozef
Autor Hanes, Jozef From the AXON Neuroscience R&D Services SE (J. Hanes, A.K., E.K., L.F., B.K., E.S., N.Z.), Bratislava, Slovakia Department of Psychiatry and Neurochemistry (H.K., H.Z., K.B.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal Clinical Neurochemistry Laboratory (H.K., H.Z., K.B.), Sahlgrenska University Hospital, Mölndal, Sweden AXON Neuroscience CRM Services SE (S.K.), Bratislava, Slovakia International Clinical Research Centre (J. Hort, M.V.), St. Anne's University Hospital Brno Memory Clinic, Department of Neurology (J. Hort, M.V.), Charles University, 2nd Faculty of Medicine and Motol University Hospital, Czech Republic Department of Clinical Chemistry, Neurochemistry Laboratory (L.B., C.E.T.), Amsterdam Neuroscience, VU University Medical Center Amsterdam, the Netherlands Axon Neuroscience SE (M.N.), Larnaca, Cyprus Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, Queen Square, London UK Dementia Research Institute at UCL (H.Z.), London Clinical Memory Research Unit (O.H.), Department of Clinical Sciences Malmö, Lund University Memory Clinic (O.H.), Skåne University Hospital, Malmö, Sweden and Department of Neurology, Alzheimer Center (P.S.), Amsterdam Neuroscience, the Netherlands
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Kovac, Andrej
Autor Kovac, Andrej From the AXON Neuroscience R&D Services SE (J. Hanes, A.K., E.K., L.F., B.K., E.S., N.Z.), Bratislava, Slovakia Department of Psychiatry and Neurochemistry (H.K., H.Z., K.B.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal Clinical Neurochemistry Laboratory (H.K., H.Z., K.B.), Sahlgrenska University Hospital, Mölndal, Sweden AXON Neuroscience CRM Services SE (S.K.), Bratislava, Slovakia International Clinical Research Centre (J. Hort, M.V.), St. Anne's University Hospital Brno Memory Clinic, Department of Neurology (J. Hort, M.V.), Charles University, 2nd Faculty of Medicine and Motol University Hospital, Czech Republic Department of Clinical Chemistry, Neurochemistry Laboratory (L.B., C.E.T.), Amsterdam Neuroscience, VU University Medical Center Amsterdam, the Netherlands Axon Neuroscience SE (M.N.), Larnaca, Cyprus Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, Queen Square, London UK Dementia Research Institute at UCL (H.Z.), London Clinical Memory Research Unit (O.H.), Department of Clinical Sciences Malmö, Lund University Memory Clinic (O.H.), Skåne University Hospital, Malmö, Sweden and Department of Neurology, Alzheimer Center (P.S.), Amsterdam Neuroscience, the Netherlands
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Kvartsberg, Hlin
Autor Kvartsberg, Hlin From the AXON Neuroscience R&D Services SE (J. Hanes, A.K., E.K., L.F., B.K., E.S., N.Z.), Bratislava, Slovakia Department of Psychiatry and Neurochemistry (H.K., H.Z., K.B.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal Clinical Neurochemistry Laboratory (H.K., H.Z., K.B.), Sahlgrenska University Hospital, Mölndal, Sweden AXON Neuroscience CRM Services SE (S.K.), Bratislava, Slovakia International Clinical Research Centre (J. Hort, M.V.), St. Anne's University Hospital Brno Memory Clinic, Department of Neurology (J. Hort, M.V.), Charles University, 2nd Faculty of Medicine and Motol University Hospital, Czech Republic Department of Clinical Chemistry, Neurochemistry Laboratory (L.B., C.E.T.), Amsterdam Neuroscience, VU University Medical Center Amsterdam, the Netherlands Axon Neuroscience SE (M.N.), Larnaca, Cyprus Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, Queen Square, London UK Dementia Research Institute at UCL (H.Z.), London Clinical Memory Research Unit (O.H.), Department of Clinical Sciences Malmö, Lund University Memory Clinic (O.H.), Skåne University Hospital, Malmö, Sweden and Department of Neurology, Alzheimer Center (P.S.), Amsterdam Neuroscience, the Netherlands
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Kontsekova, Eva
Autor Kontsekova, Eva From the AXON Neuroscience R&D Services SE (J. Hanes, A.K., E.K., L.F., B.K., E.S., N.Z.), Bratislava, Slovakia Department of Psychiatry and Neurochemistry (H.K., H.Z., K.B.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal Clinical Neurochemistry Laboratory (H.K., H.Z., K.B.), Sahlgrenska University Hospital, Mölndal, Sweden AXON Neuroscience CRM Services SE (S.K.), Bratislava, Slovakia International Clinical Research Centre (J. Hort, M.V.), St. Anne's University Hospital Brno Memory Clinic, Department of Neurology (J. Hort, M.V.), Charles University, 2nd Faculty of Medicine and Motol University Hospital, Czech Republic Department of Clinical Chemistry, Neurochemistry Laboratory (L.B., C.E.T.), Amsterdam Neuroscience, VU University Medical Center Amsterdam, the Netherlands Axon Neuroscience SE (M.N.), Larnaca, Cyprus Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, Queen Square, London UK Dementia Research Institute at UCL (H.Z.), London Clinical Memory Research Unit (O.H.), Department of Clinical Sciences Malmö, Lund University Memory Clinic (O.H.), Skåne University Hospital, Malmö, Sweden and Department of Neurology, Alzheimer Center (P.S.), Amsterdam Neuroscience, the Netherlands
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Fialova, Lubica
Autor Fialova, Lubica From the AXON Neuroscience R&D Services SE (J. Hanes, A.K., E.K., L.F., B.K., E.S., N.Z.), Bratislava, Slovakia Department of Psychiatry and Neurochemistry (H.K., H.Z., K.B.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal Clinical Neurochemistry Laboratory (H.K., H.Z., K.B.), Sahlgrenska University Hospital, Mölndal, Sweden AXON Neuroscience CRM Services SE (S.K.), Bratislava, Slovakia International Clinical Research Centre (J. Hort, M.V.), St. Anne's University Hospital Brno Memory Clinic, Department of Neurology (J. Hort, M.V.), Charles University, 2nd Faculty of Medicine and Motol University Hospital, Czech Republic Department of Clinical Chemistry, Neurochemistry Laboratory (L.B., C.E.T.), Amsterdam Neuroscience, VU University Medical Center Amsterdam, the Netherlands Axon Neuroscience SE (M.N.), Larnaca, Cyprus Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, Queen Square, London UK Dementia Research Institute at UCL (H.Z.), London Clinical Memory Research Unit (O.H.), Department of Clinical Sciences Malmö, Lund University Memory Clinic (O.H.), Skåne University Hospital, Malmö, Sweden and Department of Neurology, Alzheimer Center (P.S.), Amsterdam Neuroscience, the Netherlands
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Katina, Stanislav
Autor Katina, Stanislav From the AXON Neuroscience R&D Services SE (J. Hanes, A.K., E.K., L.F., B.K., E.S., N.Z.), Bratislava, Slovakia Department of Psychiatry and Neurochemistry (H.K., H.Z., K.B.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal Clinical Neurochemistry Laboratory (H.K., H.Z., K.B.), Sahlgrenska University Hospital, Mölndal, Sweden AXON Neuroscience CRM Services SE (S.K.), Bratislava, Slovakia International Clinical Research Centre (J. Hort, M.V.), St. Anne's University Hospital Brno Memory Clinic, Department of Neurology (J. Hort, M.V.), Charles University, 2nd Faculty of Medicine and Motol University Hospital, Czech Republic Department of Clinical Chemistry, Neurochemistry Laboratory (L.B., C.E.T.), Amsterdam Neuroscience, VU University Medical Center Amsterdam, the Netherlands Axon Neuroscience SE (M.N.), Larnaca, Cyprus Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, Queen Square, London UK Dementia Research Institute at UCL (H.Z.), London Clinical Memory Research Unit (O.H.), Department of Clinical Sciences Malmö, Lund University Memory Clinic (O.H.), Skåne University Hospital, Malmö, Sweden and Department of Neurology, Alzheimer Center (P.S.), Amsterdam Neuroscience, the Netherlands
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Kovacech, Branislav
Autor Kovacech, Branislav From the AXON Neuroscience R&D Services SE (J. Hanes, A.K., E.K., L.F., B.K., E.S., N.Z.), Bratislava, Slovakia Department of Psychiatry and Neurochemistry (H.K., H.Z., K.B.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal Clinical Neurochemistry Laboratory (H.K., H.Z., K.B.), Sahlgrenska University Hospital, Mölndal, Sweden AXON Neuroscience CRM Services SE (S.K.), Bratislava, Slovakia International Clinical Research Centre (J. Hort, M.V.), St. Anne's University Hospital Brno Memory Clinic, Department of Neurology (J. Hort, M.V.), Charles University, 2nd Faculty of Medicine and Motol University Hospital, Czech Republic Department of Clinical Chemistry, Neurochemistry Laboratory (L.B., C.E.T.), Amsterdam Neuroscience, VU University Medical Center Amsterdam, the Netherlands Axon Neuroscience SE (M.N.), Larnaca, Cyprus Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, Queen Square, London UK Dementia Research Institute at UCL (H.Z.), London Clinical Memory Research Unit (O.H.), Department of Clinical Sciences Malmö, Lund University Memory Clinic (O.H.), Skåne University Hospital, Malmö, Sweden and Department of Neurology, Alzheimer Center (P.S.), Amsterdam Neuroscience, the Netherlands
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Stevens, Eva
Autor Stevens, Eva From the AXON Neuroscience R&D Services SE (J. Hanes, A.K., E.K., L.F., B.K., E.S., N.Z.), Bratislava, Slovakia Department of Psychiatry and Neurochemistry (H.K., H.Z., K.B.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal Clinical Neurochemistry Laboratory (H.K., H.Z., K.B.), Sahlgrenska University Hospital, Mölndal, Sweden AXON Neuroscience CRM Services SE (S.K.), Bratislava, Slovakia International Clinical Research Centre (J. Hort, M.V.), St. Anne's University Hospital Brno Memory Clinic, Department of Neurology (J. Hort, M.V.), Charles University, 2nd Faculty of Medicine and Motol University Hospital, Czech Republic Department of Clinical Chemistry, Neurochemistry Laboratory (L.B., C.E.T.), Amsterdam Neuroscience, VU University Medical Center Amsterdam, the Netherlands Axon Neuroscience SE (M.N.), Larnaca, Cyprus Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, Queen Square, London UK Dementia Research Institute at UCL (H.Z.), London Clinical Memory Research Unit (O.H.), Department of Clinical Sciences Malmö, Lund University Memory Clinic (O.H.), Skåne University Hospital, Malmö, Sweden and Department of Neurology, Alzheimer Center (P.S.), Amsterdam Neuroscience, the Netherlands
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Hort, Jakub
Autor Hort, Jakub From the AXON Neuroscience R&D Services SE (J. Hanes, A.K., E.K., L.F., B.K., E.S., N.Z.), Bratislava, Slovakia Department of Psychiatry and Neurochemistry (H.K., H.Z., K.B.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal Clinical Neurochemistry Laboratory (H.K., H.Z., K.B.), Sahlgrenska University Hospital, Mölndal, Sweden AXON Neuroscience CRM Services SE (S.K.), Bratislava, Slovakia International Clinical Research Centre (J. Hort, M.V.), St. Anne's University Hospital Brno Memory Clinic, Department of Neurology (J. Hort, M.V.), Charles University, 2nd Faculty of Medicine and Motol University Hospital, Czech Republic Department of Clinical Chemistry, Neurochemistry Laboratory (L.B., C.E.T.), Amsterdam Neuroscience, VU University Medical Center Amsterdam, the Netherlands Axon Neuroscience SE (M.N.), Larnaca, Cyprus Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, Queen Square, London UK Dementia Research Institute at UCL (H.Z.), London Clinical Memory Research Unit (O.H.), Department of Clinical Sciences Malmö, Lund University Memory Clinic (O.H.), Skåne University Hospital, Malmö, Sweden and Department of Neurology, Alzheimer Center (P.S.), Amsterdam Neuroscience, the Netherlands
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Vyhnalek, Martin
Autor Vyhnalek, Martin From the AXON Neuroscience R&D Services SE (J. Hanes, A.K., E.K., L.F., B.K., E.S., N.Z.), Bratislava, Slovakia Department of Psychiatry and Neurochemistry (H.K., H.Z., K.B.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal Clinical Neurochemistry Laboratory (H.K., H.Z., K.B.), Sahlgrenska University Hospital, Mölndal, Sweden AXON Neuroscience CRM Services SE (S.K.), Bratislava, Slovakia International Clinical Research Centre (J. Hort, M.V.), St. Anne's University Hospital Brno Memory Clinic, Department of Neurology (J. Hort, M.V.), Charles University, 2nd Faculty of Medicine and Motol University Hospital, Czech Republic Department of Clinical Chemistry, Neurochemistry Laboratory (L.B., C.E.T.), Amsterdam Neuroscience, VU University Medical Center Amsterdam, the Netherlands Axon Neuroscience SE (M.N.), Larnaca, Cyprus Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, Queen Square, London UK Dementia Research Institute at UCL (H.Z.), London Clinical Memory Research Unit (O.H.), Department of Clinical Sciences Malmö, Lund University Memory Clinic (O.H.), Skåne University Hospital, Malmö, Sweden and Department of Neurology, Alzheimer Center (P.S.), Amsterdam Neuroscience, the Netherlands
OBJECTIVE: To investigate whether tau phosphorylated at Thr217 (p-tau T217) assay in CSF can distinguish patients with Alzheimer disease (AD) from patients with other dementias and healthy controls. METHODS: We developed and validated a novel Simoa immunoassay to detect p-tau T217 in CSF. There was a total of 190 participants from 3 cohorts with AD (n = 77) and other neurodegenerative diseases (n = 69) as well as healthy participants (n = 44). RESULTS: The p-tau T217 assay (cutoff 242 pg/mL) identified patients with AD with accuracy of 90%, with 78% positive predictive value (PPV), 97% negative predictive value (NPV), 93% sensitivity, and 88% specificity, compared favorably with p-tau T181 ELISA (52 pg/mL), showing 78% accuracy, 58% PPV, 98% NPV, 71% specificity, and 97% sensitivity. The assay distinguished patients with AD from age-matched healthy controls (cutoff 163 pg/mL, 98% sensitivity, 93% specificity), similarly to p-tau T181 ELISA (cutoff 60 pg/mL, 96% sensitivity, 86% specificity). In patients with AD, we found a strong correlation between p-tau T217 and p-tau T181, total tau and β-amyloid 40, but not β-amyloid 42. CONCLUSIONS: This study demonstrates that p-tau T217 displayed better diagnostic accuracy than p-tau T181. The data suggest that the new p-tau T217 assay has potential as an AD diagnostic test in clinical evaluation. CLASSIFICATION OF EVIDENCE: This study provides Class III evidence that a CSF immunoassay for p-tau T217 distinguishes patients with AD from patients with other dementias and healthy controls.
- MeSH
- Alzheimerova nemoc mozkomíšní mok diagnóza MeSH
- amyloidní beta-protein mozkomíšní mok MeSH
- diferenciální diagnóza MeSH
- frontotemporální demence mozkomíšní mok diagnóza MeSH
- imunoanalýza metody normy MeSH
- kohortové studie MeSH
- lidé středního věku MeSH
- lidé MeSH
- neurodegenerativní nemoci mozkomíšní mok diagnóza MeSH
- peptidové fragmenty mozkomíšní mok MeSH
- prediktivní hodnota testů MeSH
- primární progresivní afázie mozkomíšní mok diagnóza MeSH
- progresivní supranukleární obrna mozkomíšní mok diagnóza MeSH
- proteiny tau mozkomíšní mok MeSH
- reprodukovatelnost výsledků MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- senzitivita a specificita MeSH
- tauopatie mozkomíšní mok diagnóza MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- hodnotící studie MeSH
- práce podpořená grantem MeSH
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