- Publikační typ
- abstrakt z konference MeSH
BACKGROUND: Infection represents a less frequent cause for the development of an abdominal aortic aneurysm. The diagnosis is associated with a high risk of rapir progression and rupture. CASE REPORTS: Case 1 is a female operated on urgently for a ruptured mycotic aneurysm of the abdominal aorta. After resection of the aneurysm, we performed in situ replacement using a rifampicin-soaked vascular prosthesis. In case 2, an asymptomatic aneurysm of the right iliac artery was treated by endovascular implantation of a stent-graft. Both patients were treated with antibiotics concurrently and are still alive. DISCUSSION: The discussion deals with the up-to-date treatment modalities for mycotic aneurysms in the aorto-iliac region. The indication criteria must be adjusted individually. CONCLUSION: The prognosis of patients with a mycotic aneurysm depends particularly on an early diagnosis.
- MeSH
- aneurysma břišní aorty diagnóza chirurgie MeSH
- aneurysma ilické tepny diagnóza chirurgie MeSH
- antibakteriální látky aplikace a dávkování MeSH
- aortografie MeSH
- časná diagnóza MeSH
- cévy - implantace protéz metody MeSH
- lidé MeSH
- počítačová rentgenová tomografie MeSH
- prognóza MeSH
- ruptura aorty diagnóza chirurgie MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- stenty * MeSH
- zánětlivé aneurysma diagnóza chirurgie MeSH
- zobrazování trojrozměrné MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- kazuistiky MeSH
- Publikační typ
- abstrakt z konference MeSH
Reciprocal interactions between a tumor and its microenvironment control expansion of tumor cells. Here we show a specific type of interaction in which blasts of experimental leukemia destroy the bone marrow (BM) structures and kill stromal cells. The in vitro experiments showed that the cytotoxic agent released by leukemic cells is the fragmented DNA derived from their genome and occurring in nucleosome-like complexes. This DNA entered nuclei of BM or other cells and induced H2A.X phosphorylation at serine 139, similar to double-strand break-inducing agents. There was a correlation between large amounts of acquired DNA and death of recipient cells. Moreover, the DNA integrated into chromosomal DNA of recipient cells. Primary human acute myeloid leukemia cells also released fragmented DNA that penetrated the nuclei of other cells both in vitro and in vivo. We suggest that DNA fragments released from leukemic and also perhaps other types of tumor cells can activate DNA repair mechanisms or death in recipient cells of a tumor microenvironment, depending on the amount of the acquired DNA. This can impair DNA stability and viability of tumor stromal cells, undermine homeostatic capacity of tumor microenvironment and facilitate tumor progression.
- MeSH
- akutní myeloidní leukemie patologie MeSH
- apoptóza MeSH
- buněčné jádro metabolismus MeSH
- buňky stromatu fyziologie MeSH
- DNA metabolismus sekrece MeSH
- histony metabolismus sekrece MeSH
- kostní dřeň patologie MeSH
- kur domácí MeSH
- kuřecí embryo MeSH
- lidé MeSH
- nádorové buněčné linie MeSH
- nádorové mikroprostředí * MeSH
- nádory kostní dřeně patologie MeSH
- nukleozomy metabolismus sekrece MeSH
- oprava DNA MeSH
- poškození DNA MeSH
- progrese nemoci MeSH
- transplantace nádorů MeSH
- zvířata MeSH
- Check Tag
- kuřecí embryo MeSH
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
