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Pracoviště
Cellular and Molecular Biology Progra... 1 Department of Biological Chemistry an... 1 Department of Human Genetics Universi... 1 Department of Medicine Division of Ca... 1 Department of Obstetrics and Gynecolo... 1 Department of Urology University of M... 1 Masonic Medical Research Institute 21... 1 School of Life Science and Technology... 1
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- Autor
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Pracoviště
Cellular and Molecular Biology Progra... 1 Department of Biological Chemistry an... 1 Department of Human Genetics Universi... 1 Department of Medicine Division of Ca... 1 Department of Obstetrics and Gynecolo... 1 Department of Urology University of M... 1 Masonic Medical Research Institute 21... 1 School of Life Science and Technology... 1
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- Sheldon, Caroline
- Kessinger, Chase W
- Sun, Yan
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Kontaridis, Maria I
Autor Kontaridis, Maria I Masonic Medical Research Institute, 2150 Bleecker Street, Utica, NY 13501, United States of America Department of Medicine, Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA
- Ma, Qianyi
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Hammoud, Saher Sue
Autor Hammoud, Saher Sue Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, MI, USA Department of Urology, University of Michigan, Ann Arbor, MI, USA
- Gao, Zibei
- Zhang, Hui
- Lin, Zhiqiang
Myh6-Cre transgenic mouse line was known to express Cre recombinase only in the heart. Nevertheless, during breeding Myh6-Cre to Rosa26fstdTom reporter (tdTom) mouse line, we observed that a significant part of their F2 tdTom/+ offspring had tdTom reporter gene universally activated. Our results show that Myh6-Cre transgenic mice have Cre recombinase activity in a subpopulation of the male germline cells, and that Myh6 gene transcripts are enriched in the interstitial Leydig cells and the undifferentiated spermatogonia stem cells. In summary, the current study confirms that the previously known "heart-specific" Myh6 promoter drives Cre expression in the testis.
- MeSH
- integrasy * genetika metabolismus MeSH
- myši transgenní MeSH
- myši MeSH
- promotorové oblasti (genetika) genetika MeSH
- zárodečné buňky * metabolismus MeSH
- zvířata MeSH
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- mužské pohlaví MeSH
- myši MeSH
- zvířata MeSH
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- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
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