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Autor
Kobrlová, Tereza 2 Marco-Contelles, Jose Luis 2 Mezeiová, Eva 2 Pejchal, Jaroslav 2 Valko, Marian 2 Andrys, Rudolf 1 Andrýs, Rudolf 1 Capek, Jan 1 Handl, Jiri 1 Handl, Jiří 1 Hrabinova, Martina 1 Hrabinová, Martina 1 Janockova, Jana 1 Janočková, Jana 1 Konečný, Jan 1 Korabecny, Jan 1 Korábečný, Jan 1 Micankova, Petra 1 Mičánková, Petra 1 Muckova, Lubica 1
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Pracoviště
Institute of General Organic Chemistr... 2 Slovak University of Technology Facul... 2 Slovak University of Technology Facul... 1 University Hospital Hradec Kralove Bi... 1 University Hospital Hradec Kralove Bi... 1 University Hradec Kralove Faculty of ... 1 University Hradec Kralove Faculty of ... 1 University of Defence in Brno Faculty... 1 University of Defence in Brno Faculty... 1 University of Pardubice Faculty of Ch... 1 University of Pardubice Faculty of Ch... 1
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Autor
Kobrlová, Tereza 2 Marco-Contelles, Jose Luis 2 Mezeiová, Eva 2 Pejchal, Jaroslav 2 Valko, Marian 2 Andrys, Rudolf 1 Andrýs, Rudolf 1 Capek, Jan 1 Handl, Jiri 1 Handl, Jiří 1 Hrabinova, Martina 1 Hrabinová, Martina 1 Janockova, Jana 1 Janočková, Jana 1 Konečný, Jan 1 Korabecny, Jan 1 Korábečný, Jan 1 Micankova, Petra 1 Mičánková, Petra 1 Muckova, Lubica 1
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Pracoviště
Institute of General Organic Chemistr... 2 Slovak University of Technology Facul... 2 Slovak University of Technology Facul... 1 University Hospital Hradec Kralove Bi... 1 University Hospital Hradec Kralove Bi... 1 University Hradec Kralove Faculty of ... 1 University Hradec Kralove Faculty of ... 1 University of Defence in Brno Faculty... 1 University of Defence in Brno Faculty... 1 University of Pardubice Faculty of Ch... 1 University of Pardubice Faculty of Ch... 1
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Digitální knihovna NLK
Zdroj
E-zdroje NLK Online
ROAD: Directory of Open Access Scholarly Resources od 2011- Publikační typ
- abstrakt z konference MeSH
- Mezeiová, Eva
- Janockova, Jana
- Andrys, Rudolf
- Soukup, Ondrej
- Kobrlová, Tereza, 1991-
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Muckova, Lubica
Autor Muckova, Lubica University Hospital Hradec Kralove, Biomedical Research Centre, Sokolska 581, 500 05, Hradec Kralove, Czech Republic University of Defence in Brno, Faculty of Military Health Sciences, Department of Toxicology and Military Pharmacy, Trebesska 1575, 500 01, Hradec Kralove, Czech Republic
- Pejchal, Jaroslav
- Simunkova, Miriama
- Handl, Jiri
- Micankova, Petra
Alzheimer's disease is a progressive brain disorder with characteristic symptoms and several pathological hallmarks. The concept of "one drug, one target" has not generated any new drugs since 2004. The new era of drug development in the field of AD builds upon rationally designed multi-target directed ligands that can better address the complexity of AD. Herewith, we designed ten novel derivatives of 2-propargylamino-naphthoquinone. The biological evaluation of these compounds includes inhibition of monoamine oxidase A/B, inhibition of amyloid-beta aggregation, radical-scavenging, and metal-chelating properties. Some of the compounds possess low cytotoxicity profile with an anti-inflammatory ability in the lipopolysaccharide-stimulated cellular model. All these features warrant their further testing in the field of AD.
- MeSH
- Alzheimerova nemoc farmakoterapie MeSH
- lidé MeSH
- naftochinony farmakologie terapeutické užití MeSH
- racionální návrh léčiv MeSH
- vztahy mezi strukturou a aktivitou MeSH
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- lidé MeSH
- Publikační typ
- časopisecké články MeSH
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