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Autor
Breier, Alan 1 Cho, Kang Ik K 1 Heller, Carina 1 Holt, Daphne 1 Kasparek, Tomas 1 Keshavan, Matcheri S 1 Kikinis, Zora 1 Kubicki, Marek 1 Kudlicka, Peter 1 Lewandowski, Kathryn E 1 Lizano, Paulo 1 Losak, Jan 1 Makris, Nikos 1 Pasternak, Ofer 1 Rizzoni, Elizabeth 1 Rushmore, Jarrett 1 Seethaler, Magdalena 1 Seitz-Holland, Johanna 1 Senay, Olcay 1 Shenton, Martha E 1
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Pracoviště
Center for Morphometric Analysis Depa... 1 Central European Institute of Technol... 1 Department of Anatomy and Neurobiolog... 1 Department of Clinical Psychology Fri... 1 Department of Psychiatry Beth Israel ... 1 Department of Psychiatry Brigham and ... 1 Department of Psychiatry Faculty of M... 1 Department of Psychiatry Indiana Univ... 1 Department of Psychiatry Istanbul Fac... 1 Department of Psychiatry Massachusett... 1 Department of Psychiatry McLean Hospi... 1 Department of Psychiatry and Psychoth... 1 Department of Psychology Colby Colleg... 1 Department of Radiology Brigham and W... 1 Departments of Psychiatry and Biochem... 1
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Autor
Breier, Alan 1 Cho, Kang Ik K 1 Heller, Carina 1 Holt, Daphne 1 Kasparek, Tomas 1 Keshavan, Matcheri S 1 Kikinis, Zora 1 Kubicki, Marek 1 Kudlicka, Peter 1 Lewandowski, Kathryn E 1 Lizano, Paulo 1 Losak, Jan 1 Makris, Nikos 1 Pasternak, Ofer 1 Rizzoni, Elizabeth 1 Rushmore, Jarrett 1 Seethaler, Magdalena 1 Seitz-Holland, Johanna 1 Senay, Olcay 1 Shenton, Martha E 1
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Pracoviště
Center for Morphometric Analysis Depa... 1 Central European Institute of Technol... 1 Department of Anatomy and Neurobiolog... 1 Department of Clinical Psychology Fri... 1 Department of Psychiatry Beth Israel ... 1 Department of Psychiatry Brigham and ... 1 Department of Psychiatry Faculty of M... 1 Department of Psychiatry Indiana Univ... 1 Department of Psychiatry Istanbul Fac... 1 Department of Psychiatry Massachusett... 1 Department of Psychiatry McLean Hospi... 1 Department of Psychiatry and Psychoth... 1 Department of Psychology Colby Colleg... 1 Department of Radiology Brigham and W... 1 Departments of Psychiatry and Biochem... 1
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- Senay, Olcay
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Seethaler, Magdalena
Autor Seethaler, Magdalena ORCID Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Psychiatric University Hospital Charité at St. Hedwig Hospital, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany
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Makris, Nikos
Autor Makris, Nikos Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, Massachusetts, USA Center for Morphometric Analysis, Department of Psychiatry, Massachusetts General Hospital, Charlestown, Massachusetts, USA
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Yeterian, Edward
Autor Yeterian, Edward Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA Center for Morphometric Analysis, Department of Psychiatry, Massachusetts General Hospital, Charlestown, Massachusetts, USA Department of Psychology, Colby College, Waterville, Maine, USA
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Rushmore, Jarrett
Autor Rushmore, Jarrett Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, Massachusetts, USA Center for Morphometric Analysis, Department of Psychiatry, Massachusetts General Hospital, Charlestown, Massachusetts, USA
- Cho, Kang Ik K
- Rizzoni, Elizabeth
- Heller, Carina
- Pasternak, Ofer
- Szczepankiewicz, Filip
PubMed Central od 1998
ProQuest Central od 2021-08-01
Medline Complete (EBSCOhost) od 2012-07-01
Health & Medicine (ProQuest) od 2021-08-01
Wiley-Blackwell Open Access Titles od 1996
ROAD: Directory of Open Access Scholarly Resources od 1993
PubMed
36744628
DOI
10.1002/hbm.26224
Knihovny.cz E-zdroje
The choroid plexus (ChP) is part of the blood-cerebrospinal fluid barrier, regulating brain homeostasis and the brain's response to peripheral events. Its upregulation and enlargement are considered essential in psychosis. However, the timing of the ChP enlargement has not been established. This study introduces a novel magnetic resonance imaging-based segmentation method to examine ChP volumes in two cohorts of individuals with psychosis. The first sample consists of 41 individuals with early course psychosis (mean duration of illness = 1.78 years) and 30 healthy individuals. The second sample consists of 30 individuals with chronic psychosis (mean duration of illness = 7.96 years) and 34 healthy individuals. We utilized manual segmentation to measure ChP volumes. We applied ANCOVAs to compare normalized ChP volumes between groups and partial correlations to investigate the relationship between ChP, LV volumes, and clinical characteristics. Our segmentation demonstrated good reliability (.87). We further showed a significant ChP volume increase in early psychosis (left: p < .00010, right: p < .00010) and a significant positive correlation between higher ChP and higher LV volumes in chronic psychosis (left: r = .54, p = .0030, right: r = .68; p < .0010). Our study suggests that ChP enlargement may be a marker of acute response around disease onset. It might also play a modulatory role in the chronic enlargement of lateral ventricles, often reported in psychosis. Future longitudinal studies should investigate the dynamics of ChP enlargement as a promising marker for novel therapeutic strategies.
- MeSH
- lidé MeSH
- magnetická rezonanční tomografie MeSH
- mozek patologie MeSH
- plexus chorioideus * diagnostické zobrazování patologie MeSH
- psychotické poruchy * diagnostické zobrazování patologie MeSH
- reprodukovatelnost výsledků MeSH
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- lidé MeSH
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- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
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