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A preliminary choroid plexus volumetric study in individuals with psychosis

O. Senay, M. Seethaler, N. Makris, E. Yeterian, J. Rushmore, KIK. Cho, E. Rizzoni, C. Heller, O. Pasternak, F. Szczepankiewicz, CF. Westin, J. Losak, L. Ustohal, J. Tomandl, L. Vojtisek, P. Kudlicka, Z. Kikinis, D. Holt, KE. Lewandowski, P....

. 2023 ; 44 (6) : 2465-2478. [pub] 20230206

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, Research Support, N.I.H., Extramural, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc23003623

Grantová podpora
U01 MH109977 NIMH NIH HHS - United States
K24 MH110807 NIMH NIH HHS - United States
R01 MH102377 NIMH NIH HHS - United States

The choroid plexus (ChP) is part of the blood-cerebrospinal fluid barrier, regulating brain homeostasis and the brain's response to peripheral events. Its upregulation and enlargement are considered essential in psychosis. However, the timing of the ChP enlargement has not been established. This study introduces a novel magnetic resonance imaging-based segmentation method to examine ChP volumes in two cohorts of individuals with psychosis. The first sample consists of 41 individuals with early course psychosis (mean duration of illness = 1.78 years) and 30 healthy individuals. The second sample consists of 30 individuals with chronic psychosis (mean duration of illness = 7.96 years) and 34 healthy individuals. We utilized manual segmentation to measure ChP volumes. We applied ANCOVAs to compare normalized ChP volumes between groups and partial correlations to investigate the relationship between ChP, LV volumes, and clinical characteristics. Our segmentation demonstrated good reliability (.87). We further showed a significant ChP volume increase in early psychosis (left: p < .00010, right: p < .00010) and a significant positive correlation between higher ChP and higher LV volumes in chronic psychosis (left: r = .54, p = .0030, right: r = .68; p < .0010). Our study suggests that ChP enlargement may be a marker of acute response around disease onset. It might also play a modulatory role in the chronic enlargement of lateral ventricles, often reported in psychosis. Future longitudinal studies should investigate the dynamics of ChP enlargement as a promising marker for novel therapeutic strategies.

Center for Morphometric Analysis Department of Psychiatry Massachusetts General Hospital Charlestown Massachusetts USA

Central European Institute of Technology Masaryk University Neuroscience Centre Brno Czech Republic

Department of Anatomy and Neurobiology Boston University School of Medicine Boston Massachusetts USA

Department of Clinical Psychology Friedrich Schiller University Jena Jena Germany

Department of Psychiatry and Psychotherapy Campus Charité Mitte Psychiatric University Hospital Charité at St Hedwig Hospital Charité Universitätsmedizin Berlin Corporate Member of Freie Universität Berlin Humboldt Universität zu Berlin and Berlin Institute of Health Berlin Germany

Department of Psychiatry Beth Israel Deaconess Medical Center Harvard Medical School Boston Massachusetts USA

Department of Psychiatry Brigham and Women's Hospital Harvard Medical School Boston Massachusetts USA

Department of Psychiatry Faculty of Medicine Masaryk University and University Hospital Brno Brno Czech Republic

Department of Psychiatry Indiana University School of Medicine Indianapolis Indiana USA

Department of Psychiatry Istanbul Faculty of Medicine Istanbul University Istanbul Turkey

Department of Psychiatry Massachusetts General Hospital Harvard Medical School Boston Massachusetts USA

Department of Psychiatry McLean Hospital Harvard Medical School Belmont Massachusetts USA

Department of Psychology Colby College Waterville Maine USA

Department of Radiology Brigham and Women's Hospital Harvard Medical School Boston Massachusetts USA

Departments of Psychiatry and Biochemistry Faculty of Medicine Masaryk University and University Hospital Brno Brno Czech Republic

Citace poskytuje Crossref.org

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