The conditions determining network-forming and aggregation properties of hyaluronan on the mica surface were studied. The hyaluronan was deposited on the surface from aqueous and saline solutions and attached by a bivalent cation. The morphology of the immobilized assemblies was characterized by atomic force microscopy. The experimental results show that the morphology and size of the aggregates as well as the density of the interconnecting fibrillar network, both made of hyaluronan, at the liquid-solid phase interface are determined not only by its molecular weight or concentration in solution, but also by the dissolution conditions and storage time. These findings extend the current state of knowledge about the conformational variability of this biologically important polymer. Understanding the conformational variability is of great importance, as it governs the physiological functions of hyaluronan, as well as its processability and formulations. That in turn determines its usability in different pharmacological and biomaterial applications.
- MeSH
- hydrofobní a hydrofilní interakce MeSH
- hypertonický solný roztok chemie MeSH
- kyselina hyaluronová chemie MeSH
- mikroskopie atomárních sil metody MeSH
- molekulární struktura MeSH
- molekulová hmotnost MeSH
- polymery chemie MeSH
- povrchové vlastnosti MeSH
- rozpustnost MeSH
- silikáty hliníku chemie MeSH
- skladování léků MeSH
- voda chemie MeSH
- vodíková vazba MeSH
- Publikační typ
- časopisecké články MeSH
Maghemite nanoparticle based silicone composite for application in arterial embolization hyperthermia is developed. It possesses embolization ability, high heating efficiency in alternating magnetic fields and radiopaque property. The initial components of the composite are selected so that the material stays liquid for 20min, providing the opportunity for transcatheter transportation and filling of the tumour vascular system. After this induction period the viscosity increases rapidly and soft embolus is formed which is able to occlude the tumour blood vessels. The composite is thermally stable up to 225°C, displays rubber-elastic properties and has a thermal expansion coefficient higher than that of blood. Maghemite nanoparticles uniformly distributed in the composite provide its rapid heating (tens of °Cmin(-1)) due to Neel magnetization relaxation. Required X-ray contrast of composite is achieved by addition of potassium iodide.
- MeSH
- indukovaná hypertermie * MeSH
- jodid draselný chemie MeSH
- lidé MeSH
- magnetické pole * MeSH
- nanokompozity chemie MeSH
- pružnost MeSH
- silikony chemie MeSH
- terapeutická embolizace * MeSH
- železité sloučeniny chemie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- MeSH
- inteligence klasifikace MeSH
- inteligenční testy MeSH
- lidé MeSH
- Check Tag
- lidé MeSH
- MeSH
- lidé MeSH
- sezónní afektivní porucha psychologie MeSH
- Check Tag
- lidé MeSH
- MeSH
- lidé MeSH
- pracovní zátěž MeSH
- psychický stres prevence a kontrola MeSH
- životní styl MeSH
- Check Tag
- lidé MeSH
- MeSH
- interpersonální vztahy MeSH
- konflikt (psychologie) MeSH
- lidé MeSH
- manželství psychologie zákonodárství a právo MeSH
- nesouhlas a spor dějiny zákonodárství a právo MeSH
- právní vědy dějiny MeSH
- rodina psychologie MeSH
- sociální péče klasifikace psychologie zákonodárství a právo MeSH
- trest dějiny psychologie MeSH
- trestní zákon dějiny metody trendy MeSH
- Check Tag
- lidé MeSH
