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Autor
Beganovic, Mirela 1 Bozhkov, Peter V 1 Cardoso, Catarina 1 Dalman, Kerstin 1 Elander, Pernilla H 1 Hofius, Daniel 1 Lindberg Yilmaz, Jenny 1 Liu, Qinsong 1 Ljung, Karin 1 Marmon, Sofia 1 Minina, Elena A 1 Moschou, Panagiotis N 1 Novák, Ondrej 1 Sanchez-Vera, Victoria 1 Shabala, Lana 1 Shabala, Sergey 1 Stymne, Sten 1 Suarez, Maria F 1 Vetukuri, Ramesh R 1
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Pracoviště
Departamento de Biologia Molecular y ... 1 Department of Molecular Sciences Upps... 1 Department of Plant Biology Uppsala B... 1 Department of Plant Biology Uppsala B... 1 Department of Plant Breeding Swedish ... 1 Laboratory of Growth Regulators Centr... 1 ScanBiRes AB Alnarp Sweden 1 School of Land and Food University of... 1 Umeå Plant Science Centre Department ... 1
- Formát
- Publikační typ
- Kategorie
- Jazyk
- Země
- Časopis/zdroj
- Dostupnost
- Vlastník
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Autor
Beganovic, Mirela 1 Bozhkov, Peter V 1 Cardoso, Catarina 1 Dalman, Kerstin 1 Elander, Pernilla H 1 Hofius, Daniel 1 Lindberg Yilmaz, Jenny 1 Liu, Qinsong 1 Ljung, Karin 1 Marmon, Sofia 1 Minina, Elena A 1 Moschou, Panagiotis N 1 Novák, Ondrej 1 Sanchez-Vera, Victoria 1 Shabala, Lana 1 Shabala, Sergey 1 Stymne, Sten 1 Suarez, Maria F 1 Vetukuri, Ramesh R 1
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Pracoviště
Departamento de Biologia Molecular y ... 1 Department of Molecular Sciences Upps... 1 Department of Plant Biology Uppsala B... 1 Department of Plant Biology Uppsala B... 1 Department of Plant Breeding Swedish ... 1 Laboratory of Growth Regulators Centr... 1 ScanBiRes AB Alnarp Sweden 1 School of Land and Food University of... 1 Umeå Plant Science Centre Department ... 1
- Formát
- Publikační typ
- Kategorie
- Jazyk
- Země
- Časopis/zdroj
- Dostupnost
- Vlastník
NLK
Free Medical Journals
od 1996 do Před 1 rokem
Open Access Digital Library
od 1996-01-01
PubMed
29365132
DOI
10.1093/jxb/ery010
Knihovny.cz E-zdroje
Autophagy is a major catabolic process whereby autophagosomes deliver cytoplasmic content to the lytic compartment for recycling. Autophagosome formation requires two ubiquitin-like systems conjugating Atg12 with Atg5, and Atg8 with lipid phosphatidylethanolamine (PE), respectively. Genetic suppression of these systems causes autophagy-deficient phenotypes with reduced fitness and longevity. We show that Atg5 and the E1-like enzyme, Atg7, are rate-limiting components of Atg8-PE conjugation in Arabidopsis. Overexpression of ATG5 or ATG7 stimulates Atg8 lipidation, autophagosome formation, and autophagic flux. It also induces transcriptional changes opposite to those observed in atg5 and atg7 mutants, favoring stress resistance and growth. As a result, ATG5- or ATG7-overexpressing plants exhibit increased resistance to necrotrophic pathogens and oxidative stress, delayed aging and enhanced growth, seed set, and seed oil content. This work provides an experimental paradigm and mechanistic insight into genetic stimulation of autophagy in planta and shows its efficiency for improving plant productivity.
- MeSH
- Arabidopsis genetika fyziologie MeSH
- Atg5 genetika metabolismus MeSH
- autofagie genetika MeSH
- genetická zdatnost * MeSH
- proteiny huseníčku genetika metabolismus MeSH
- rodina proteinů Atg8 genetika metabolismus MeSH
- signální transdukce genetika MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
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