Ionic liquids are increasingly used for their superior properties. Four water-immiscible ionic liquids (butyltriethylammonium bis(trifluoromethylsulfonyl)imide, octyltriethylammonium bis(trifluoromethylsulfonyl)imide, dodecyltriethylammonium bis(trifluoromethylsulfonyl)imide, butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide) and their water miscible precursors (bromides) were synthesized in a microwave reactor and by conventional heating. The best conditions for microwave-assisted synthesis concerning the yield and the purity of the product are proposed. The heating in the microwave reactor significantly shortened the reaction time. Biocide and ecotoxic effects of synthesized ionic liquids and their precursors were investigated. All tested compounds had at least a little effect on the growth or living of microorganisms (bacteria or mold). The precursor dodecyltriethylammonium bromide was found to be the strongest biocide, but posed a risk to the aquatic environment due to its relatively high EC50 value in the test with Vibrio fischeri. We assumed that apart from the alkyl chain length, the solubility in water, duration of action, or type of anion can influence the final biocide and ecotoxic effect.
- MeSH
- Aliivibrio fischeri účinky léků MeSH
- amoniové sloučeniny chemie MeSH
- antibakteriální látky chemická syntéza farmakologie MeSH
- antifungální látky chemická syntéza chemie farmakologie MeSH
- ekotoxikologie metody MeSH
- imidazoly chemie MeSH
- iontové kapaliny chemická syntéza farmakologie MeSH
- kvartérní amoniové sloučeniny chemická syntéza farmakologie MeSH
- mikrovlny MeSH
- preklinické hodnocení léčiv metody MeSH
- Publikační typ
- časopisecké články MeSH
A methodology for preparing phosphonium-based ionic liquid modified silica-based monolithic capillary columns is presented. The silica monolithic columns with dimensions of 150 × 0.1 mm were modified by a phosphonium-based ionic liquid (trioctyl(3/4-vinylbenzyl)phosphonium chloride) via 3-(trimethoxysilyl)propyl methacrylate. The prepared columns were evaluated under hydrophilic interaction liquid chromatography separation conditions, employing a sample mixture containing purine and pyrimidine bases and nucleosides. Detection was made by UV. The high efficiency of the original silica monolith was preserved even after modification, and it reached values in the range of 98,000-174,000 theoretical plates/m. The effects of the concentration of acetonitrile in the mobile phase, the presence of additives in the mobile phase, such as, acetic acid or ammonium acetate, and the pH of the mobile phase on the separation of some selected analytes were investigated. The prepared columns showed different separation selectivity compared to silica, phenyl and sulfobetaine stationary phases.
- MeSH
- betain analogy a deriváty chemie MeSH
- chromatografie kapalinová metody MeSH
- hydrofobní a hydrofilní interakce MeSH
- iontové kapaliny chemická syntéza chemie MeSH
- nukleosidy analýza MeSH
- organofosforové sloučeniny chemie MeSH
- oxid křemičitý chemie MeSH
- poréznost MeSH
- reprodukovatelnost výsledků MeSH
- Publikační typ
- časopisecké články MeSH
