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Autor
Bonnarme, Pascal 1 Boucheix, Claude 1 Briozzo, Pierre 1 Chadefaux-Vekemans, Bernadette 1 Dairou, Julien 1 Desterke, Christophe 1 Gaston-Mathé, Yann 1 Goldschmidt, Emma 1 Haghighi-Rad, Farhad 1 Hamelin, Jocelyne 1 Kopečný, David 1 Machover, David 1 Magnani, Mauro 1 Mollicone, Rosella 1 Pierigè, Francesca 1 Rossi, Luigia 1 Saffroy, Raphaël 1
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Pracoviště
Assistance Publique Hôpitaux de Paris... 1 Assistance Publique Hôpitaux de Paris... 1 CNRS UMR 8601 Paris France 1 CRH Department of Protein Biochemistr... 1 INRA AgroParisTech UMR 782 GMPA Thive... 1 INSERM U1193 Villejuif France 1 INSERM U1197 Villejuif France 1 INSERM U935 Villejuif France 1 Institut Jean Pierre Bourgin INRA Agr... 1 University Paris Descartes Paris France 1 University Paris Saclay Paris France 1 University Paris Sud Villejuif France 1 University of Urbino Carlo Bo Urbino ... 1 YGM Consult SAS Paris France 1
- Formát
- Publikační typ
- Check Tag
- Kategorie
- Jazyk
- Země
- Časopis/zdroj
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- Vlastník
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Autor
Bonnarme, Pascal 1 Boucheix, Claude 1 Briozzo, Pierre 1 Chadefaux-Vekemans, Bernadette 1 Dairou, Julien 1 Desterke, Christophe 1 Gaston-Mathé, Yann 1 Goldschmidt, Emma 1 Haghighi-Rad, Farhad 1 Hamelin, Jocelyne 1 Kopečný, David 1 Machover, David 1 Magnani, Mauro 1 Mollicone, Rosella 1 Pierigè, Francesca 1 Rossi, Luigia 1 Saffroy, Raphaël 1
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Pracoviště
Assistance Publique Hôpitaux de Paris... 1 Assistance Publique Hôpitaux de Paris... 1 CNRS UMR 8601 Paris France 1 CRH Department of Protein Biochemistr... 1 INRA AgroParisTech UMR 782 GMPA Thive... 1 INSERM U1193 Villejuif France 1 INSERM U1197 Villejuif France 1 INSERM U935 Villejuif France 1 Institut Jean Pierre Bourgin INRA Agr... 1 University Paris Descartes Paris France 1 University Paris Saclay Paris France 1 University Paris Sud Villejuif France 1 University of Urbino Carlo Bo Urbino ... 1 YGM Consult SAS Paris France 1
- Formát
- Publikační typ
- Check Tag
- Kategorie
- Jazyk
- Země
- Časopis/zdroj
- Dostupnost
- Vlastník
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Machover, David
Autor Machover, David Assistance Publique-Hôpitaux de Paris, Hospital Paul-Brousse, Villejuif, France (D.M., J.H., E.G., R.S.,) INSERM U935, Villejuif, France (D.M., C.D., F.H.-R., C.B.) University Paris-Sud, Villejuif, France (D.M., J.H., C.D., R.M., F.H.-R., C.B., R.S.) University Paris-Saclay, Paris, France (D.M., J.H., C.D., R.M., F.H.-R., C.B., R.S.) University of Urbino Carlo Bo, Urbino, Italy (L.R., F.P., M.M.) INSERM U1193, Villejuif, France (J.H., R.S.) INSERM U1197, Villejuif, France (R.M.) INRA-AgroParisTech, UMR 782 GMPA, Thiverval-Grignon, France (P.Bo.) Institut Jean-Pierre Bourgin, INRA-AgroParisTech, University Paris-Saclay, Versailles, France (P.Br.) CRH-Department of Protein Biochemistry and Proteomics, Palacký University, Olomouc, Czech Republic (D.K.) YGM Consult SAS, Paris, France (Y.G.-M.) CNRS UMR 8601, Paris, France (J.D.) Assistance Publique-Hôpitaux de Paris, Hospital Necker-Enfants Malades, Paris. France (B.C.-V.) and University Paris-Descartes, Paris, France (B.C.-V., J.D.) david.machover1@orange.fr david.machover@aphp.fr
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Rossi, Luigia
Autor Rossi, Luigia Assistance Publique-Hôpitaux de Paris, Hospital Paul-Brousse, Villejuif, France (D.M., J.H., E.G., R.S.,) INSERM U935, Villejuif, France (D.M., C.D., F.H.-R., C.B.) University Paris-Sud, Villejuif, France (D.M., J.H., C.D., R.M., F.H.-R., C.B., R.S.) University Paris-Saclay, Paris, France (D.M., J.H., C.D., R.M., F.H.-R., C.B., R.S.) University of Urbino Carlo Bo, Urbino, Italy (L.R., F.P., M.M.) INSERM U1193, Villejuif, France (J.H., R.S.) INSERM U1197, Villejuif, France (R.M.) INRA-AgroParisTech, UMR 782 GMPA, Thiverval-Grignon, France (P.Bo.) Institut Jean-Pierre Bourgin, INRA-AgroParisTech, University Paris-Saclay, Versailles, France (P.Br.) CRH-Department of Protein Biochemistry and Proteomics, Palacký University, Olomouc, Czech Republic (D.K.) YGM Consult SAS, Paris, France (Y.G.-M.) CNRS UMR 8601, Paris, France (J.D.) Assistance Publique-Hôpitaux de Paris, Hospital Necker-Enfants Malades, Paris. France (B.C.-V.) and University Paris-Descartes, Paris, France (B.C.-V., J.D.)
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Hamelin, Jocelyne
Autor Hamelin, Jocelyne Assistance Publique-Hôpitaux de Paris, Hospital Paul-Brousse, Villejuif, France (D.M., J.H., E.G., R.S.,) INSERM U935, Villejuif, France (D.M., C.D., F.H.-R., C.B.) University Paris-Sud, Villejuif, France (D.M., J.H., C.D., R.M., F.H.-R., C.B., R.S.) University Paris-Saclay, Paris, France (D.M., J.H., C.D., R.M., F.H.-R., C.B., R.S.) University of Urbino Carlo Bo, Urbino, Italy (L.R., F.P., M.M.) INSERM U1193, Villejuif, France (J.H., R.S.) INSERM U1197, Villejuif, France (R.M.) INRA-AgroParisTech, UMR 782 GMPA, Thiverval-Grignon, France (P.Bo.) Institut Jean-Pierre Bourgin, INRA-AgroParisTech, University Paris-Saclay, Versailles, France (P.Br.) CRH-Department of Protein Biochemistry and Proteomics, Palacký University, Olomouc, Czech Republic (D.K.) YGM Consult SAS, Paris, France (Y.G.-M.) CNRS UMR 8601, Paris, France (J.D.) Assistance Publique-Hôpitaux de Paris, Hospital Necker-Enfants Malades, Paris. France (B.C.-V.) and University Paris-Descartes, Paris, France (B.C.-V., J.D.)
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Desterke, Christophe
Autor Desterke, Christophe Assistance Publique-Hôpitaux de Paris, Hospital Paul-Brousse, Villejuif, France (D.M., J.H., E.G., R.S.,) INSERM U935, Villejuif, France (D.M., C.D., F.H.-R., C.B.) University Paris-Sud, Villejuif, France (D.M., J.H., C.D., R.M., F.H.-R., C.B., R.S.) University Paris-Saclay, Paris, France (D.M., J.H., C.D., R.M., F.H.-R., C.B., R.S.) University of Urbino Carlo Bo, Urbino, Italy (L.R., F.P., M.M.) INSERM U1193, Villejuif, France (J.H., R.S.) INSERM U1197, Villejuif, France (R.M.) INRA-AgroParisTech, UMR 782 GMPA, Thiverval-Grignon, France (P.Bo.) Institut Jean-Pierre Bourgin, INRA-AgroParisTech, University Paris-Saclay, Versailles, France (P.Br.) CRH-Department of Protein Biochemistry and Proteomics, Palacký University, Olomouc, Czech Republic (D.K.) YGM Consult SAS, Paris, France (Y.G.-M.) CNRS UMR 8601, Paris, France (J.D.) Assistance Publique-Hôpitaux de Paris, Hospital Necker-Enfants Malades, Paris. France (B.C.-V.) and University Paris-Descartes, Paris, France (B.C.-V., J.D.)
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Goldschmidt, Emma
Autor Goldschmidt, Emma Assistance Publique-Hôpitaux de Paris, Hospital Paul-Brousse, Villejuif, France (D.M., J.H., E.G., R.S.,) INSERM U935, Villejuif, France (D.M., C.D., F.H.-R., C.B.) University Paris-Sud, Villejuif, France (D.M., J.H., C.D., R.M., F.H.-R., C.B., R.S.) University Paris-Saclay, Paris, France (D.M., J.H., C.D., R.M., F.H.-R., C.B., R.S.) University of Urbino Carlo Bo, Urbino, Italy (L.R., F.P., M.M.) INSERM U1193, Villejuif, France (J.H., R.S.) INSERM U1197, Villejuif, France (R.M.) INRA-AgroParisTech, UMR 782 GMPA, Thiverval-Grignon, France (P.Bo.) Institut Jean-Pierre Bourgin, INRA-AgroParisTech, University Paris-Saclay, Versailles, France (P.Br.) CRH-Department of Protein Biochemistry and Proteomics, Palacký University, Olomouc, Czech Republic (D.K.) YGM Consult SAS, Paris, France (Y.G.-M.) CNRS UMR 8601, Paris, France (J.D.) Assistance Publique-Hôpitaux de Paris, Hospital Necker-Enfants Malades, Paris. France (B.C.-V.) and University Paris-Descartes, Paris, France (B.C.-V., J.D.)
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Chadefaux-Vekemans, Bernadette
Autor Chadefaux-Vekemans, Bernadette Assistance Publique-Hôpitaux de Paris, Hospital Paul-Brousse, Villejuif, France (D.M., J.H., E.G., R.S.,) INSERM U935, Villejuif, France (D.M., C.D., F.H.-R., C.B.) University Paris-Sud, Villejuif, France (D.M., J.H., C.D., R.M., F.H.-R., C.B., R.S.) University Paris-Saclay, Paris, France (D.M., J.H., C.D., R.M., F.H.-R., C.B., R.S.) University of Urbino Carlo Bo, Urbino, Italy (L.R., F.P., M.M.) INSERM U1193, Villejuif, France (J.H., R.S.) INSERM U1197, Villejuif, France (R.M.) INRA-AgroParisTech, UMR 782 GMPA, Thiverval-Grignon, France (P.Bo.) Institut Jean-Pierre Bourgin, INRA-AgroParisTech, University Paris-Saclay, Versailles, France (P.Br.) CRH-Department of Protein Biochemistry and Proteomics, Palacký University, Olomouc, Czech Republic (D.K.) YGM Consult SAS, Paris, France (Y.G.-M.) CNRS UMR 8601, Paris, France (J.D.) Assistance Publique-Hôpitaux de Paris, Hospital Necker-Enfants Malades, Paris. France (B.C.-V.) and University Paris-Descartes, Paris, France (B.C.-V., J.D.)
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Bonnarme, Pascal
Autor Bonnarme, Pascal Assistance Publique-Hôpitaux de Paris, Hospital Paul-Brousse, Villejuif, France (D.M., J.H., E.G., R.S.,) INSERM U935, Villejuif, France (D.M., C.D., F.H.-R., C.B.) University Paris-Sud, Villejuif, France (D.M., J.H., C.D., R.M., F.H.-R., C.B., R.S.) University Paris-Saclay, Paris, France (D.M., J.H., C.D., R.M., F.H.-R., C.B., R.S.) University of Urbino Carlo Bo, Urbino, Italy (L.R., F.P., M.M.) INSERM U1193, Villejuif, France (J.H., R.S.) INSERM U1197, Villejuif, France (R.M.) INRA-AgroParisTech, UMR 782 GMPA, Thiverval-Grignon, France (P.Bo.) Institut Jean-Pierre Bourgin, INRA-AgroParisTech, University Paris-Saclay, Versailles, France (P.Br.) CRH-Department of Protein Biochemistry and Proteomics, Palacký University, Olomouc, Czech Republic (D.K.) YGM Consult SAS, Paris, France (Y.G.-M.) CNRS UMR 8601, Paris, France (J.D.) Assistance Publique-Hôpitaux de Paris, Hospital Necker-Enfants Malades, Paris. France (B.C.-V.) and University Paris-Descartes, Paris, France (B.C.-V., J.D.)
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Briozzo, Pierre
Autor Briozzo, Pierre Assistance Publique-Hôpitaux de Paris, Hospital Paul-Brousse, Villejuif, France (D.M., J.H., E.G., R.S.,) INSERM U935, Villejuif, France (D.M., C.D., F.H.-R., C.B.) University Paris-Sud, Villejuif, France (D.M., J.H., C.D., R.M., F.H.-R., C.B., R.S.) University Paris-Saclay, Paris, France (D.M., J.H., C.D., R.M., F.H.-R., C.B., R.S.) University of Urbino Carlo Bo, Urbino, Italy (L.R., F.P., M.M.) INSERM U1193, Villejuif, France (J.H., R.S.) INSERM U1197, Villejuif, France (R.M.) INRA-AgroParisTech, UMR 782 GMPA, Thiverval-Grignon, France (P.Bo.) Institut Jean-Pierre Bourgin, INRA-AgroParisTech, University Paris-Saclay, Versailles, France (P.Br.) CRH-Department of Protein Biochemistry and Proteomics, Palacký University, Olomouc, Czech Republic (D.K.) YGM Consult SAS, Paris, France (Y.G.-M.) CNRS UMR 8601, Paris, France (J.D.) Assistance Publique-Hôpitaux de Paris, Hospital Necker-Enfants Malades, Paris. France (B.C.-V.) and University Paris-Descartes, Paris, France (B.C.-V., J.D.)
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Kopečný, David
Autor Kopečný, David Assistance Publique-Hôpitaux de Paris, Hospital Paul-Brousse, Villejuif, France (D.M., J.H., E.G., R.S.,) INSERM U935, Villejuif, France (D.M., C.D., F.H.-R., C.B.) University Paris-Sud, Villejuif, France (D.M., J.H., C.D., R.M., F.H.-R., C.B., R.S.) University Paris-Saclay, Paris, France (D.M., J.H., C.D., R.M., F.H.-R., C.B., R.S.) University of Urbino Carlo Bo, Urbino, Italy (L.R., F.P., M.M.) INSERM U1193, Villejuif, France (J.H., R.S.) INSERM U1197, Villejuif, France (R.M.) INRA-AgroParisTech, UMR 782 GMPA, Thiverval-Grignon, France (P.Bo.) Institut Jean-Pierre Bourgin, INRA-AgroParisTech, University Paris-Saclay, Versailles, France (P.Br.) CRH-Department of Protein Biochemistry and Proteomics, Palacký University, Olomouc, Czech Republic (D.K.) YGM Consult SAS, Paris, France (Y.G.-M.) CNRS UMR 8601, Paris, France (J.D.) Assistance Publique-Hôpitaux de Paris, Hospital Necker-Enfants Malades, Paris. France (B.C.-V.) and University Paris-Descartes, Paris, France (B.C.-V., J.D.)
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Pierigè, Francesca
Autor Pierigè, Francesca Assistance Publique-Hôpitaux de Paris, Hospital Paul-Brousse, Villejuif, France (D.M., J.H., E.G., R.S.,) INSERM U935, Villejuif, France (D.M., C.D., F.H.-R., C.B.) University Paris-Sud, Villejuif, France (D.M., J.H., C.D., R.M., F.H.-R., C.B., R.S.) University Paris-Saclay, Paris, France (D.M., J.H., C.D., R.M., F.H.-R., C.B., R.S.) University of Urbino Carlo Bo, Urbino, Italy (L.R., F.P., M.M.) INSERM U1193, Villejuif, France (J.H., R.S.) INSERM U1197, Villejuif, France (R.M.) INRA-AgroParisTech, UMR 782 GMPA, Thiverval-Grignon, France (P.Bo.) Institut Jean-Pierre Bourgin, INRA-AgroParisTech, University Paris-Saclay, Versailles, France (P.Br.) CRH-Department of Protein Biochemistry and Proteomics, Palacký University, Olomouc, Czech Republic (D.K.) YGM Consult SAS, Paris, France (Y.G.-M.) CNRS UMR 8601, Paris, France (J.D.) Assistance Publique-Hôpitaux de Paris, Hospital Necker-Enfants Malades, Paris. France (B.C.-V.) and University Paris-Descartes, Paris, France (B.C.-V., J.D.)
Open Access Digital Library od 1997-01-01 do Před 1 rokem
PubMed
30940696
DOI
10.1124/jpet.119.256537
Knihovny.cz E-zdroje
Methionine deprivation induces growth arrest and death of cancer cells. To eliminate l-methionine we produced, purified, and characterized the recombinant pyridoxal 5'-phosphate (PLP)-dependent l-methionine γ-lyase (MGL)- BL929 from the cheese-ripening Brevibacterium aurantiacum Transformation of an Escherichia coli strain with the gene BL929 from B. aurantiacum optimized for E. coli expression led to production of the MGL-BL929. Elimination of l-methionine and cytotoxicity in vitro were assessed, and methylation-sensitive epigenetics was explored for changes resulting from exposure of cancer cells to the enzyme. A bioreactor was built by encapsulation of the protein in human erythrocytes to achieve sustained elimination of l-methionine in extracellular fluids. Catalysis was limited to α,γ-elimination of l-methionine and l-homocysteine. The enzyme had no activity on other sulfur-containing amino acids. Enzyme activity decreased in presence of serum albumin or plasma resulting from reduction of PLP availability. Elimination of l-methionine induced cytotoxicity on a vast panel of human cancer cell lines and spared normal cells. Exposure of colorectal carcinoma cells to the MGL-BL929 reduced methyl-CpG levels of hypermethylated gene promoters including that of CDKN2A, whose mRNA expression was increased, together with a decrease in global histone H3 dimethyl lysine 9. The MGL-erythrocyte bioreactor durably preserves enzyme activity in vitro and strongly eliminates l-methionine from medium.
- MeSH
- bioreaktory MeSH
- Brevibacterium enzymologie MeSH
- dospělí MeSH
- erytrocyty účinky léků metabolismus MeSH
- lidé MeSH
- lyasy štěpící vazby C-S farmakologie MeSH
- methionin metabolismus MeSH
- myši MeSH
- nádorové buněčné linie MeSH
- rekombinantní proteiny farmakologie MeSH
- tobolky MeSH
- zvířata MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
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Po ukončení testovacího provozu bude odkaz přesměrován adresu produkční verze portálu Medvik.