20-Hydroxyecdysterone - (2β,3β,5β,22R)-2,3,14,20,22,25-hexahydroxycholest-7-en-6-one was isolated in satisfactory yield using ethanol extraction from the aerial part of Silene wolgensis (Hornem.) Otth; sometimes Silene wolgensis (Willd.) Bess. ex Spreng. The complexation of the phytoecdysteroid with β-cyclodextrin was studied by NMR spectroscopy. By studying the changes in chemical shifts of protons of substrates and receptors it was found that ecdysterone interacts with cyclodextrins to form supramolecular inclusion complexes of stoichiometric composition of 1:1 or 1:2. Ecdysterone-β-cyclodextrin complexes exhibit 100 times higher solubility in water than the parent compound.
- Klíčová slova
- Cyclodextrins, Ecdysterones, Inclusion complexes, NMR spectroscopy,
- MeSH
- biologická dostupnost MeSH
- cyklodextriny chemie MeSH
- ekdysteron chemie izolace a purifikace farmakokinetika MeSH
- magnetická rezonanční spektroskopie MeSH
- molekulární konformace MeSH
- rozpustnost MeSH
- Silene chemie MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- cyklodextriny MeSH
- ekdysteron MeSH
