OBJECTIVES: To introduce and assess the efficacy and risks associated with a new treatment method of post-catheterization pseudoaneurysms. METHODS: Thrombin injection was indicated in patients with failure of compression therapy during 24 hours. Patients with a cavity volume < 1 cm3, with a pseudoaneurysm causing compression or haemorrhagic shock were excluded. A needle is introduced under local anaesthesia with ultrasound guidance, its tip is placed thoroughly in the centre of the cavity. Subsequently, under colour-flow mapping, thrombin solution with concentration of 1000 IU/ml is cautiously injected, which results in instantaneous thrombosis of the pseudoaneurysm cavity. RESULTS: Thrombin injection was used in 17 patients during a period of 12 months. 12 of them were women, 6 patients with valvular disease, 2 after intervention and 5 anticoagulated. The method was successful in 16 patients. In 5 of them, a small residual cavity persisted, which was not suitable for re-injection, and was closed completely after a few minutes of compression by a ultrasound transducer. There were no thrombotic complications. CONCLUSION: Although compression remains the method of choice, thrombin injection is a highly effective, quick and, with necessary precautions, safe alternative to surgical treatment of pseudoaneurysms, mainly in anticoagulated patients.

• MeSH
• arteria femoralis * diagnostické zobrazování   zranění   MeSH
• hemostatika aplikace a dávkování   MeSH
• injekce MeSH
• intervenční ultrasonografie MeSH
• lidé středního věku MeSH
• lidé MeSH
• nepravé aneurysma diagnostické zobrazování   etiologie   terapie   MeSH
• periferní katetrizace škodlivé účinky   MeSH
• senioři MeSH
• thrombin aplikace a dávkování   MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• hemostatika MeSH
• thrombin MeSH

The nephrotoxicity of various combinations of antibiotics--aminoglycosides, cephalosporins, vancomycin, amphotericin B--in 171 oncologic patients is described. The most nephrotoxic combination seems to be cefotaxime plus gentamicin, ceftriaxone plus amikacin and amphotericin B with cephalosporin, vancomycin or aminoglycoside. Less toxic was netilmicin with penicillin or cephalosporin, and vancomycin.

• MeSH
• amfotericin B škodlivé účinky   MeSH
• aminoglykosidy MeSH
• antibakteriální látky škodlivé účinky   MeSH
• cefalosporiny škodlivé účinky   MeSH
• kombinovaná farmakoterapie škodlivé účinky   MeSH
• ledviny účinky léků   MeSH
• lidé MeSH
• nádory komplikace   MeSH
• retrospektivní studie MeSH
• vankomycin škodlivé účinky   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• amfotericin B MeSH
• aminoglykosidy MeSH
• antibakteriální látky MeSH
• cefalosporiny MeSH
• vankomycin MeSH