Severe burn injuries cause functional impairment in distant internal organs. Although this mechanism is not clear, it is possible that free radical toxicity plays an important role. Research in animals and clinical studies have shown that there is a close relationship between a lipid peroxidative reaction and secondary pathological changes following thermal injury. It has been demonstrated that antioxidant treatment prevents oxidative tissue damage associated with thermal trauma. This study was designed to determine the possible protective effect of caffeic acid phenethyl ester (CAPE) treatment against oxidative damage in the kidney and lung induced by thermal injury. Rats were decapitated either 1, 3 or 7 days after burn injury. CAPE was administered intraperitoneally immediately after thermal injury. Kidney and lung tissues were taken for the determination of malondialdehyde (MDA) level, myeloperoxidase (MPO), catalase (CAT), superoxide dismutase (SOD) and xanthine oxidase (XO) activities. Severe skin thermal injury caused a significant decrease in SOD and CAT activities, as well as significant increases in MDA level, XO and MPO activities in tissues during the postburn period. Treatment of rats with CAPE (10 micromol/kg) significantly elevated the decreased SOD and CAT activities, while it decreased MDA levels and MPO as well as XO activity.
- MeSH
- fenethylalkohol aplikace a dávkování analogy a deriváty MeSH
- injekce intraperitoneální MeSH
- krysa rodu Rattus MeSH
- kyseliny kávové aplikace a dávkování MeSH
- malondialdehyd metabolismus MeSH
- modely nemocí na zvířatech MeSH
- multiorgánové selhání farmakoterapie etiologie metabolismus MeSH
- nemoci ledvin farmakoterapie etiologie metabolismus MeSH
- oxidoreduktasy metabolismus MeSH
- plicní nemoci farmakoterapie etiologie metabolismus MeSH
- popálení komplikace metabolismus MeSH
- potkani Wistar MeSH
- výsledek terapie MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- caffeic acid phenethyl ester MeSH Prohlížeč
- fenethylalkohol MeSH
- kyseliny kávové MeSH
- malondialdehyd MeSH
- oxidoreduktasy MeSH
