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Autor
Bezlyak, Vladimir 1 Butzkueven, Helmut 1 Drahota, Jiri 1 Ellenberger, David 1 Forsberg, Lars 1 Friede, Tim 1 Glaser, Anna 1 Hillert, Jan 1 Horakova, Dana 1 Joensen, Hanna 1 Klyve, Pernilla 1 Lerede, Annalaura 1 Lines, Carol 1 Magyari, Melinda 1 Manouchehrinia, Ali 1 Middleton, Rod 1 Nicholas, Richard 1 Pontieri, Luigi 1 Ramanujam, Ryan 1 Rodgers, Jeff 1
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Pracoviště
Czech National Multiple Sclerosis Pat... 1 Danish Multiple Sclerosis Registry De... 1 Department of Cellular and Molecular ... 1 Department of Clinical Neuroscience K... 1 Department of Clinical Neuroscience K... 1 Department of Clinical Neurosciences ... 1 Department of Mathematics KTH Royal I... 1 Department of Medical Statistics Univ... 1 Department of Neurology Danish Multip... 1 Department of Neurology and Center of... 1 Department of Neuroscience Central Cl... 1 Department of Visual Neuroscience UCL... 1 Faculty of Medicine Health and Life S... 1 Faculty of Medicine Health and Life S... 1 German MS Registry MS Forschungs und ... 1 Novartis Pharma AG Basel Switzerland 1 Swansea University Medical School Swa... 1
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Autor
Bezlyak, Vladimir 1 Butzkueven, Helmut 1 Drahota, Jiri 1 Ellenberger, David 1 Forsberg, Lars 1 Friede, Tim 1 Glaser, Anna 1 Hillert, Jan 1 Horakova, Dana 1 Joensen, Hanna 1 Klyve, Pernilla 1 Lerede, Annalaura 1 Lines, Carol 1 Magyari, Melinda 1 Manouchehrinia, Ali 1 Middleton, Rod 1 Nicholas, Richard 1 Pontieri, Luigi 1 Ramanujam, Ryan 1 Rodgers, Jeff 1
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Pracoviště
Czech National Multiple Sclerosis Pat... 1 Danish Multiple Sclerosis Registry De... 1 Department of Cellular and Molecular ... 1 Department of Clinical Neuroscience K... 1 Department of Clinical Neuroscience K... 1 Department of Clinical Neurosciences ... 1 Department of Mathematics KTH Royal I... 1 Department of Medical Statistics Univ... 1 Department of Neurology Danish Multip... 1 Department of Neurology and Center of... 1 Department of Neuroscience Central Cl... 1 Department of Visual Neuroscience UCL... 1 Faculty of Medicine Health and Life S... 1 Faculty of Medicine Health and Life S... 1 German MS Registry MS Forschungs und ... 1 Novartis Pharma AG Basel Switzerland 1 Swansea University Medical School Swa... 1
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PubMed
37771841
PubMed Central
PMC10524069
DOI
10.1177/17562864231198963
PII: 10.1177_17562864231198963
Knihovny.cz E-zdroje
INTRODUCTION: Prescribing guidance for disease-modifying treatment (DMT) in multiple sclerosis (MS) is centred on a clinical diagnosis of relapsing-remitting MS (RRMS). DMT prescription guidelines and monitoring vary across countries. Standardising the approach to diagnosis of disease course, for example, assigning RRMS or secondary progressive MS (SPMS) diagnoses, allows examination of the impact of health system characteristics on the stated clinical diagnosis and treatment access. METHODS: We analysed registry data from six cohorts in five countries (Czech Republic, Denmark, Germany, Sweden and United Kingdom) on patients with an initial diagnosis of RRMS. We standardised our approach utilising a pre-existing algorithm (DecisionTree, DT) to determine patient diagnoses of RRMS or secondary progressive MS (SPMS). We identified five global drivers of DMT prescribing: Provision, Availability, Funding, Monitoring and Audit, data were analysed against these concepts using meta-analysis and univariate meta-regression. RESULTS: In 64,235 patients, we found variations in DMT use between countries, with higher usage in RRMS and lower usage in SPMS, with correspondingly lower usage in the UK compared to other registers. Factors such as female gender (p = 0.041), increasing disability via Expanded Disability Status Scale (EDSS) score (p = 0.004), and the presence of monitoring (p = 0.029) in SPMS influenced the likelihood of receiving DMTs. Standardising the diagnosis revealed differences in reclassification rates from clinical RRMS to DT-SPMS, with Sweden having the lowest rate Sweden (Sweden 0.009, range: Denmark 0.103 - UK portal 0.311). Those with higher EDSS at index (p < 0.03) and female gender (p < 0.049) were more likely to be reclassified from RRMS to DT-SPMS. The study also explored the impact of diagnosis on DMT usage in clinical SPMS, finding that the prescribing environment and auditing practices affected access to treatment. DISCUSSION: This highlights the importance of a healthcare system's approach to verifying the clinical label of MS course in facilitating appropriate prescribing, with some flexibility allowed in uncertain cases to ensure continued access to treatment.
- Klíčová slova
- big data, clinical audit, decision tree, disease registers, international collaboration, multiple sclerosis,
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Po ukončení testovacího provozu bude odkaz přesměrován adresu produkční verze portálu Medvik.