• MeSH
• ischemie mozku * patofyziologie   MeSH
• modely nemocí na zvířatech * MeSH
• mozková hypoxie * patofyziologie   MeSH
• techniky in vitro MeSH
• zvířata MeSH
• Check Tag
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH

The problem of space flights called for the need to construct ground-base models which imitate or simulate some reactions of the organism to the complex of spaceflight factors, mainly to microgravity. In this review the processes and models simulating flight factors and their advantages and disadvantages are described. The authors have supplemented the models used until now by a new modification of suspension hypokinesia, so-called safety-pin suspension. This model appears to be simple and inexpensive. It causes relatively weak traumatic stress and this may be demonstrated by daily weighing of the animals.

• MeSH
• biologické modely MeSH
• gravitace * MeSH
• imobilizace fyziologie   MeSH
• krysa rodu Rattus MeSH
• letecké a kosmické lékařství MeSH
• zvířata MeSH
• Check Tag
• krysa rodu Rattus MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH

The ribonucleic acid (RNA) and protein content of the ventromedial hypothalamic nuclei (VMH), the lateral hypothalamic areas (LHA) and the cortex (C) of adult male Wistar rats followed free access to food and water were determined at 6-hour intervals (at 6.00, 12.00, 18.00 and 24.00 h); the RNA and protein content of the suprachiasmatic nuclei (SCN) were determined at 12.00 and 24.00 h. The RNA content of the VMH, LHA and SCN differed at various intervals; in the cortex it did not alter significantly. The highest RNA concentration in the VMH was recorded at 18.00 h and in the LHA at 24.00 h, after which, in both areas, it fell. The lowest RNA content in the LHA and the VMH was found at 12.00 h. In the SCN, the RNA concentration at 24.00 h was significantly higher than at 12.00 h. The protein content did not alter significantly during the circadian cycle in any of the structures examined.

• MeSH
• area hypothalamica lateralis analýza   metabolismus   MeSH
• časové faktory MeSH
• cirkadiánní rytmus * MeSH
• inbrední kmeny potkanů MeSH
• krysa rodu Rattus MeSH
• mozková kůra analýza   metabolismus   MeSH
• nucleus suprachiasmaticus analýza   metabolismus   MeSH
• nucleus ventromedialis hypothalami analýza   metabolismus   MeSH
• přijímání potravy * MeSH
• proteiny analýza   MeSH
• RNA analýza   MeSH
• zvířata MeSH
• Check Tag
• krysa rodu Rattus MeSH
• mužské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• srovnávací studie MeSH
• Názvy látek
• proteiny MeSH
• RNA MeSH

The objective of this study was to determine the effects of bovine growth hormone (bGH) on body growth of suckling lambs. Suckling Merino lambs (fed on milk replacer from 4th day of life) were daily injected from 10th to 38th day of life with 80 micrograms bGH/kg b.w. Only insignificant increase of body weight was observed after 4 weeks of GH treatment. After 31st day of life body weight gain in the experimental lambs was significantly higher. It can be concluded that bGH increases body weight gain of lambs in 2nd month of life. It is probable that growth rate of sucklings is limited only by biological and biochemical capabilities of the organism and it can be hardly influenced by exogenous hormonal manipulation.

• MeSH
• kojená zvířata metabolismus   MeSH
• ovce růst a vývoj   MeSH
• růstový hormon farmakologie   MeSH
• skot MeSH
• tělesná hmotnost účinky léků   MeSH
• zvířata MeSH
• Check Tag
• skot MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• růstový hormon MeSH

• MeSH
• area hypothalamica lateralis metabolismus   MeSH
• DNA metabolismus   MeSH
• inbrední kmeny potkanů MeSH
• inzulin farmakologie   MeSH
• krysa rodu Rattus MeSH
• nucleus ventromedialis hypothalami metabolismus   MeSH
• přijímání potravy účinky léků   MeSH
• proteiny nervové tkáně metabolismus   MeSH
• RNA metabolismus   MeSH
• zvířata MeSH
• Check Tag
• krysa rodu Rattus MeSH
• mužské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• anglický abstrakt MeSH
• časopisecké články MeSH
• Názvy látek
• DNA MeSH
• inzulin MeSH
• proteiny nervové tkáně MeSH
• RNA MeSH

The objective of this study was to determine the effects of growth hormone on body growth and the content of RNA, DNA and protein in liver, brain and heart muscle in rat pups from reduced nests. Suckling rats raised in litters of 4 youngs were daily injected from 3rd to 28th day of life with 1 microgram of bGH/g body weight. Our results show that GH administration evoked higher body weight gain and increase of tail length after 23rd day of life. There was significant increase of liver content of nucleic acids and protein. This GH-responsivity of pups from reduced nests might be related to differences in their metabolic profile and accelerated somatic and psychosocial development in comparison to normal youngs.

• MeSH
• DNA metabolismus   MeSH
• inbrední kmeny potkanů MeSH
• játra účinky léků   metabolismus   MeSH
• kojená zvířata růst a vývoj   metabolismus   MeSH
• krysa rodu Rattus MeSH
• mozek účinky léků   metabolismus   MeSH
• myokard metabolismus   MeSH
• proteiny metabolismus   MeSH
• receptory somatotropinu metabolismus   MeSH
• RNA metabolismus   MeSH
• růstový hormon farmakologie   MeSH
• srdce účinky léků   MeSH
• tělesná hmotnost účinky léků   MeSH
• velikost vrhu * MeSH
• zvířata MeSH
• Check Tag
• krysa rodu Rattus MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• DNA MeSH
• proteiny MeSH
• receptory somatotropinu MeSH
• RNA MeSH
• růstový hormon MeSH

We studied the influence of the three main nutritive components of milk - saccharides, fat and amino acids - on milk intake in suckling lambs and on the role of insulin as a key metabolic hormone for the regulation of milk intake. The intake was slowed down after p.o. administration of milk fat (p less than 0.05), after i. v. administration of methionine (p less than 0.001) and after p. o. administration of glucose, lactose (p less than 0.01, p less than 0.001) and sorbitol (p less than 0.001). After i. v. administration of glycerol, lysine, threonine, arginine, glucose, and i. v. and p. o. administration of galactose the intake of milk did not change significantly (p greater than 0.05). The findings indicate that the short-time regulation of milk intake in suckling ruminant animals is not subjected to the specific effect of some of the milk components. Regarding the metabolic effects, the problem concerns the speed of resorption of easily metabolizable sources of energy from the digestive system to the liver and to the whole body. Neutral Zn-insulin administered intraperitoneally at a dose of 4 U X kg-1 increased the milk intake (p less than 0.01, p less than 0.001), in 8 to 22 hours after the administration only when the animals were on the low-fat milk diet (5.9%-11% fat in dry matter). We assume that the long-range hyperphagy can be related mainly with the fast metabolizing of energy-rich substances (glucose) into the body stores (glycogen, fat) accompanied by subsequent hormonal changes.(ABSTRACT TRUNCATED AT 250 WORDS)

• MeSH
• aminokyseliny aplikace a dávkování   MeSH
• kojená zvířata fyziologie   MeSH
• mléko MeSH
• ovce fyziologie   MeSH
• sacharidy aplikace a dávkování   MeSH
• stravovací zvyklosti fyziologie   MeSH
• tuky aplikace a dávkování   MeSH
• zvířata MeSH
• Check Tag
• zvířata MeSH
• Publikační typ
• anglický abstrakt MeSH
• časopisecké články MeSH
• Názvy látek
• aminokyseliny MeSH
• sacharidy MeSH
• tuky MeSH