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Effect of Treatment on Damage and Hospitalization in Elderly Patients with Microscopic Polyangiitis and Granulomatosis with Polyangiitis

Weiner, Maria
Autor Weiner, Maria From the Department of Nephrology and Department of Medical and Health Sciences, Department of Rheumatology and Department of Clinical and Experimental Medicine, Linköping University, Linköping; Department of Clinical Sciences, Section of Rheumatology, Lund University, Lund; Department of Renal Medicine, Karolinska University Hospital and CLINTEC Karolinska Institute, Stockholm; Department of Nephrology, Lund University, Skåne University Hospital, Lund and Malmö; University College London Centre for Nephrology, Royal Free Hospital; Department of Medicine, Imperial College London, London; Institute of Clinical Sciences, University of Birmingham, Birmingham; Department of Medicine, University of Cambridge, Cambridge, UK; Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Department of Renal Medicine, Tan Tock Seng Hospital, Singapore. maria.weiner@liu.se M. Weiner, MD, Department of Nephrology and Department of Medical and Health Sciences, Linköping University; S.M. Goh, MBBS, University College London Centre for Nephrology, Royal Free Hospital, and Department of Renal Medicine, Tan Tock Seng Hospital; A.J. Mohammad, MD, PhD, Department of Clinical Sciences, Section of Rheumatology, Lund University, and Department of Medicine, University of Cambridge; Z. Hrušková, MD, PhD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; A. Tanna, MD, Department of Medicine, Imperial College London; P. Sharp, PhD, Institute of Clinical Sciences, University of Birmingham; A. Kang, MBBS, Department of Medicine, Imperial College London; A. Bruchfeld, MD, PhD, Department of Renal Medicine, Karolinska University Hospital and CLINTEC Karolinska Institute; D. Selga, MD, PhD, Department of Nephrology, Lund University, Skåne University Hospital; Z. Chocová, MD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; K. Westman, MD, PhD, Department of Nephrology, Lund University, Skåne University Hospital; P. Eriksson, MD, PhD, Department of Rheumatology and Department of Clinical and Experimental Medicine, Linköping University; L. Harper, MBChB, PhD, Institute of Clinical Sciences, University of Birmingham; C.D. Pusey, DSc, FMedSci, Department of Medicine, Imperial College London; V. Tesař, MD, PhD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; A.D. Salama, MBBS, FRCP, PhD, University College London Centre for Nephrology, Royal Free Hospital; M. Segelmark, MD, PhD, Department of Nephrology and Department of Medical and Health Sciences, Linköping University. maria.weiner@liu.se
Goh, Su Mein
Autor Goh, Su Mein From the Department of Nephrology and Department of Medical and Health Sciences, Department of Rheumatology and Department of Clinical and Experimental Medicine, Linköping University, Linköping; Department of Clinical Sciences, Section of Rheumatology, Lund University, Lund; Department of Renal Medicine, Karolinska University Hospital and CLINTEC Karolinska Institute, Stockholm; Department of Nephrology, Lund University, Skåne University Hospital, Lund and Malmö; University College London Centre for Nephrology, Royal Free Hospital; Department of Medicine, Imperial College London, London; Institute of Clinical Sciences, University of Birmingham, Birmingham; Department of Medicine, University of Cambridge, Cambridge, UK; Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Department of Renal Medicine, Tan Tock Seng Hospital, Singapore M. Weiner, MD, Department of Nephrology and Department of Medical and Health Sciences, Linköping University; S.M. Goh, MBBS, University College London Centre for Nephrology, Royal Free Hospital, and Department of Renal Medicine, Tan Tock Seng Hospital; A.J. Mohammad, MD, PhD, Department of Clinical Sciences, Section of Rheumatology, Lund University, and Department of Medicine, University of Cambridge; Z. Hrušková, MD, PhD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; A. Tanna, MD, Department of Medicine, Imperial College London; P. Sharp, PhD, Institute of Clinical Sciences, University of Birmingham; A. Kang, MBBS, Department of Medicine, Imperial College London; A. Bruchfeld, MD, PhD, Department of Renal Medicine, Karolinska University Hospital and CLINTEC Karolinska Institute; D. Selga, MD, PhD, Department of Nephrology, Lund University, Skåne University Hospital; Z. Chocová, MD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; K. Westman, MD, PhD, Department of Nephrology, Lund University, Skåne University Hospital; P. Eriksson, MD, PhD, Department of Rheumatology and Department of Clinical and Experimental Medicine, Linköping University; L. Harper, MBChB, PhD, Institute of Clinical Sciences, University of Birmingham; C.D. Pusey, DSc, FMedSci, Department of Medicine, Imperial College London; V. Tesař, MD, PhD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; A.D. Salama, MBBS, FRCP, PhD, University College London Centre for Nephrology, Royal Free Hospital; M. Segelmark, MD, PhD, Department of Nephrology and Department of Medical and Health Sciences, Linköping University
Mohammad, Aladdin J
Autor Mohammad, Aladdin J ORCID From the Department of Nephrology and Department of Medical and Health Sciences, Department of Rheumatology and Department of Clinical and Experimental Medicine, Linköping University, Linköping; Department of Clinical Sciences, Section of Rheumatology, Lund University, Lund; Department of Renal Medicine, Karolinska University Hospital and CLINTEC Karolinska Institute, Stockholm; Department of Nephrology, Lund University, Skåne University Hospital, Lund and Malmö; University College London Centre for Nephrology, Royal Free Hospital; Department of Medicine, Imperial College London, London; Institute of Clinical Sciences, University of Birmingham, Birmingham; Department of Medicine, University of Cambridge, Cambridge, UK; Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Department of Renal Medicine, Tan Tock Seng Hospital, Singapore M. Weiner, MD, Department of Nephrology and Department of Medical and Health Sciences, Linköping University; S.M. Goh, MBBS, University College London Centre for Nephrology, Royal Free Hospital, and Department of Renal Medicine, Tan Tock Seng Hospital; A.J. Mohammad, MD, PhD, Department of Clinical Sciences, Section of Rheumatology, Lund University, and Department of Medicine, University of Cambridge; Z. Hrušková, MD, PhD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; A. Tanna, MD, Department of Medicine, Imperial College London; P. Sharp, PhD, Institute of Clinical Sciences, University of Birmingham; A. Kang, MBBS, Department of Medicine, Imperial College London; A. Bruchfeld, MD, PhD, Department of Renal Medicine, Karolinska University Hospital and CLINTEC Karolinska Institute; D. Selga, MD, PhD, Department of Nephrology, Lund University, Skåne University Hospital; Z. Chocová, MD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; K. Westman, MD, PhD, Department of Nephrology, Lund University, Skåne University Hospital; P. Eriksson, MD, PhD, Department of Rheumatology and Department of Clinical and Experimental Medicine, Linköping University; L. Harper, MBChB, PhD, Institute of Clinical Sciences, University of Birmingham; C.D. Pusey, DSc, FMedSci, Department of Medicine, Imperial College London; V. Tesař, MD, PhD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; A.D. Salama, MBBS, FRCP, PhD, University College London Centre for Nephrology, Royal Free Hospital; M. Segelmark, MD, PhD, Department of Nephrology and Department of Medical and Health Sciences, Linköping University
Hrušková, Zdenka
Autor Autorita ORCID From the Department of Nephrology and Department of Medical and Health Sciences, Department of Rheumatology and Department of Clinical and Experimental Medicine, Linköping University, Linköping; Department of Clinical Sciences, Section of Rheumatology, Lund University, Lund; Department of Renal Medicine, Karolinska University Hospital and CLINTEC Karolinska Institute, Stockholm; Department of Nephrology, Lund University, Skåne University Hospital, Lund and Malmö; University College London Centre for Nephrology, Royal Free Hospital; Department of Medicine, Imperial College London, London; Institute of Clinical Sciences, University of Birmingham, Birmingham; Department of Medicine, University of Cambridge, Cambridge, UK; Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Department of Renal Medicine, Tan Tock Seng Hospital, Singapore M. Weiner, MD, Department of Nephrology and Department of Medical and Health Sciences, Linköping University; S.M. Goh, MBBS, University College London Centre for Nephrology, Royal Free Hospital, and Department of Renal Medicine, Tan Tock Seng Hospital; A.J. Mohammad, MD, PhD, Department of Clinical Sciences, Section of Rheumatology, Lund University, and Department of Medicine, University of Cambridge; Z. Hrušková, MD, PhD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; A. Tanna, MD, Department of Medicine, Imperial College London; P. Sharp, PhD, Institute of Clinical Sciences, University of Birmingham; A. Kang, MBBS, Department of Medicine, Imperial College London; A. Bruchfeld, MD, PhD, Department of Renal Medicine, Karolinska University Hospital and CLINTEC Karolinska Institute; D. Selga, MD, PhD, Department of Nephrology, Lund University, Skåne University Hospital; Z. Chocová, MD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; K. Westman, MD, PhD, Department of Nephrology, Lund University, Skåne University Hospital; P. Eriksson, MD, PhD, Department of Rheumatology and Department of Clinical and Experimental Medicine, Linköping University; L. Harper, MBChB, PhD, Institute of Clinical Sciences, University of Birmingham; C.D. Pusey, DSc, FMedSci, Department of Medicine, Imperial College London; V. Tesař, MD, PhD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; A.D. Salama, MBBS, FRCP, PhD, University College London Centre for Nephrology, Royal Free Hospital; M. Segelmark, MD, PhD, Department of Nephrology and Department of Medical and Health Sciences, Linköping University
Tanna, Anisha
Autor Tanna, Anisha From the Department of Nephrology and Department of Medical and Health Sciences, Department of Rheumatology and Department of Clinical and Experimental Medicine, Linköping University, Linköping; Department of Clinical Sciences, Section of Rheumatology, Lund University, Lund; Department of Renal Medicine, Karolinska University Hospital and CLINTEC Karolinska Institute, Stockholm; Department of Nephrology, Lund University, Skåne University Hospital, Lund and Malmö; University College London Centre for Nephrology, Royal Free Hospital; Department of Medicine, Imperial College London, London; Institute of Clinical Sciences, University of Birmingham, Birmingham; Department of Medicine, University of Cambridge, Cambridge, UK; Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Department of Renal Medicine, Tan Tock Seng Hospital, Singapore M. Weiner, MD, Department of Nephrology and Department of Medical and Health Sciences, Linköping University; S.M. Goh, MBBS, University College London Centre for Nephrology, Royal Free Hospital, and Department of Renal Medicine, Tan Tock Seng Hospital; A.J. Mohammad, MD, PhD, Department of Clinical Sciences, Section of Rheumatology, Lund University, and Department of Medicine, University of Cambridge; Z. Hrušková, MD, PhD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; A. Tanna, MD, Department of Medicine, Imperial College London; P. Sharp, PhD, Institute of Clinical Sciences, University of Birmingham; A. Kang, MBBS, Department of Medicine, Imperial College London; A. Bruchfeld, MD, PhD, Department of Renal Medicine, Karolinska University Hospital and CLINTEC Karolinska Institute; D. Selga, MD, PhD, Department of Nephrology, Lund University, Skåne University Hospital; Z. Chocová, MD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; K. Westman, MD, PhD, Department of Nephrology, Lund University, Skåne University Hospital; P. Eriksson, MD, PhD, Department of Rheumatology and Department of Clinical and Experimental Medicine, Linköping University; L. Harper, MBChB, PhD, Institute of Clinical Sciences, University of Birmingham; C.D. Pusey, DSc, FMedSci, Department of Medicine, Imperial College London; V. Tesař, MD, PhD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; A.D. Salama, MBBS, FRCP, PhD, University College London Centre for Nephrology, Royal Free Hospital; M. Segelmark, MD, PhD, Department of Nephrology and Department of Medical and Health Sciences, Linköping University
Sharp, Phoebe
Autor Sharp, Phoebe From the Department of Nephrology and Department of Medical and Health Sciences, Department of Rheumatology and Department of Clinical and Experimental Medicine, Linköping University, Linköping; Department of Clinical Sciences, Section of Rheumatology, Lund University, Lund; Department of Renal Medicine, Karolinska University Hospital and CLINTEC Karolinska Institute, Stockholm; Department of Nephrology, Lund University, Skåne University Hospital, Lund and Malmö; University College London Centre for Nephrology, Royal Free Hospital; Department of Medicine, Imperial College London, London; Institute of Clinical Sciences, University of Birmingham, Birmingham; Department of Medicine, University of Cambridge, Cambridge, UK; Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Department of Renal Medicine, Tan Tock Seng Hospital, Singapore M. Weiner, MD, Department of Nephrology and Department of Medical and Health Sciences, Linköping University; S.M. Goh, MBBS, University College London Centre for Nephrology, Royal Free Hospital, and Department of Renal Medicine, Tan Tock Seng Hospital; A.J. Mohammad, MD, PhD, Department of Clinical Sciences, Section of Rheumatology, Lund University, and Department of Medicine, University of Cambridge; Z. Hrušková, MD, PhD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; A. Tanna, MD, Department of Medicine, Imperial College London; P. Sharp, PhD, Institute of Clinical Sciences, University of Birmingham; A. Kang, MBBS, Department of Medicine, Imperial College London; A. Bruchfeld, MD, PhD, Department of Renal Medicine, Karolinska University Hospital and CLINTEC Karolinska Institute; D. Selga, MD, PhD, Department of Nephrology, Lund University, Skåne University Hospital; Z. Chocová, MD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; K. Westman, MD, PhD, Department of Nephrology, Lund University, Skåne University Hospital; P. Eriksson, MD, PhD, Department of Rheumatology and Department of Clinical and Experimental Medicine, Linköping University; L. Harper, MBChB, PhD, Institute of Clinical Sciences, University of Birmingham; C.D. Pusey, DSc, FMedSci, Department of Medicine, Imperial College London; V. Tesař, MD, PhD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; A.D. Salama, MBBS, FRCP, PhD, University College London Centre for Nephrology, Royal Free Hospital; M. Segelmark, MD, PhD, Department of Nephrology and Department of Medical and Health Sciences, Linköping University
Kang, Amy
Autor Kang, Amy From the Department of Nephrology and Department of Medical and Health Sciences, Department of Rheumatology and Department of Clinical and Experimental Medicine, Linköping University, Linköping; Department of Clinical Sciences, Section of Rheumatology, Lund University, Lund; Department of Renal Medicine, Karolinska University Hospital and CLINTEC Karolinska Institute, Stockholm; Department of Nephrology, Lund University, Skåne University Hospital, Lund and Malmö; University College London Centre for Nephrology, Royal Free Hospital; Department of Medicine, Imperial College London, London; Institute of Clinical Sciences, University of Birmingham, Birmingham; Department of Medicine, University of Cambridge, Cambridge, UK; Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Department of Renal Medicine, Tan Tock Seng Hospital, Singapore M. Weiner, MD, Department of Nephrology and Department of Medical and Health Sciences, Linköping University; S.M. Goh, MBBS, University College London Centre for Nephrology, Royal Free Hospital, and Department of Renal Medicine, Tan Tock Seng Hospital; A.J. Mohammad, MD, PhD, Department of Clinical Sciences, Section of Rheumatology, Lund University, and Department of Medicine, University of Cambridge; Z. Hrušková, MD, PhD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; A. Tanna, MD, Department of Medicine, Imperial College London; P. Sharp, PhD, Institute of Clinical Sciences, University of Birmingham; A. Kang, MBBS, Department of Medicine, Imperial College London; A. Bruchfeld, MD, PhD, Department of Renal Medicine, Karolinska University Hospital and CLINTEC Karolinska Institute; D. Selga, MD, PhD, Department of Nephrology, Lund University, Skåne University Hospital; Z. Chocová, MD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; K. Westman, MD, PhD, Department of Nephrology, Lund University, Skåne University Hospital; P. Eriksson, MD, PhD, Department of Rheumatology and Department of Clinical and Experimental Medicine, Linköping University; L. Harper, MBChB, PhD, Institute of Clinical Sciences, University of Birmingham; C.D. Pusey, DSc, FMedSci, Department of Medicine, Imperial College London; V. Tesař, MD, PhD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; A.D. Salama, MBBS, FRCP, PhD, University College London Centre for Nephrology, Royal Free Hospital; M. Segelmark, MD, PhD, Department of Nephrology and Department of Medical and Health Sciences, Linköping University
Bruchfeld, Annette
Autor Bruchfeld, Annette ORCID From the Department of Nephrology and Department of Medical and Health Sciences, Department of Rheumatology and Department of Clinical and Experimental Medicine, Linköping University, Linköping; Department of Clinical Sciences, Section of Rheumatology, Lund University, Lund; Department of Renal Medicine, Karolinska University Hospital and CLINTEC Karolinska Institute, Stockholm; Department of Nephrology, Lund University, Skåne University Hospital, Lund and Malmö; University College London Centre for Nephrology, Royal Free Hospital; Department of Medicine, Imperial College London, London; Institute of Clinical Sciences, University of Birmingham, Birmingham; Department of Medicine, University of Cambridge, Cambridge, UK; Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Department of Renal Medicine, Tan Tock Seng Hospital, Singapore M. Weiner, MD, Department of Nephrology and Department of Medical and Health Sciences, Linköping University; S.M. Goh, MBBS, University College London Centre for Nephrology, Royal Free Hospital, and Department of Renal Medicine, Tan Tock Seng Hospital; A.J. Mohammad, MD, PhD, Department of Clinical Sciences, Section of Rheumatology, Lund University, and Department of Medicine, University of Cambridge; Z. Hrušková, MD, PhD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; A. Tanna, MD, Department of Medicine, Imperial College London; P. Sharp, PhD, Institute of Clinical Sciences, University of Birmingham; A. Kang, MBBS, Department of Medicine, Imperial College London; A. Bruchfeld, MD, PhD, Department of Renal Medicine, Karolinska University Hospital and CLINTEC Karolinska Institute; D. Selga, MD, PhD, Department of Nephrology, Lund University, Skåne University Hospital; Z. Chocová, MD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; K. Westman, MD, PhD, Department of Nephrology, Lund University, Skåne University Hospital; P. Eriksson, MD, PhD, Department of Rheumatology and Department of Clinical and Experimental Medicine, Linköping University; L. Harper, MBChB, PhD, Institute of Clinical Sciences, University of Birmingham; C.D. Pusey, DSc, FMedSci, Department of Medicine, Imperial College London; V. Tesař, MD, PhD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; A.D. Salama, MBBS, FRCP, PhD, University College London Centre for Nephrology, Royal Free Hospital; M. Segelmark, MD, PhD, Department of Nephrology and Department of Medical and Health Sciences, Linköping University
Selga, Daina
Autor Selga, Daina From the Department of Nephrology and Department of Medical and Health Sciences, Department of Rheumatology and Department of Clinical and Experimental Medicine, Linköping University, Linköping; Department of Clinical Sciences, Section of Rheumatology, Lund University, Lund; Department of Renal Medicine, Karolinska University Hospital and CLINTEC Karolinska Institute, Stockholm; Department of Nephrology, Lund University, Skåne University Hospital, Lund and Malmö; University College London Centre for Nephrology, Royal Free Hospital; Department of Medicine, Imperial College London, London; Institute of Clinical Sciences, University of Birmingham, Birmingham; Department of Medicine, University of Cambridge, Cambridge, UK; Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Department of Renal Medicine, Tan Tock Seng Hospital, Singapore M. Weiner, MD, Department of Nephrology and Department of Medical and Health Sciences, Linköping University; S.M. Goh, MBBS, University College London Centre for Nephrology, Royal Free Hospital, and Department of Renal Medicine, Tan Tock Seng Hospital; A.J. Mohammad, MD, PhD, Department of Clinical Sciences, Section of Rheumatology, Lund University, and Department of Medicine, University of Cambridge; Z. Hrušková, MD, PhD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; A. Tanna, MD, Department of Medicine, Imperial College London; P. Sharp, PhD, Institute of Clinical Sciences, University of Birmingham; A. Kang, MBBS, Department of Medicine, Imperial College London; A. Bruchfeld, MD, PhD, Department of Renal Medicine, Karolinska University Hospital and CLINTEC Karolinska Institute; D. Selga, MD, PhD, Department of Nephrology, Lund University, Skåne University Hospital; Z. Chocová, MD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; K. Westman, MD, PhD, Department of Nephrology, Lund University, Skåne University Hospital; P. Eriksson, MD, PhD, Department of Rheumatology and Department of Clinical and Experimental Medicine, Linköping University; L. Harper, MBChB, PhD, Institute of Clinical Sciences, University of Birmingham; C.D. Pusey, DSc, FMedSci, Department of Medicine, Imperial College London; V. Tesař, MD, PhD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; A.D. Salama, MBBS, FRCP, PhD, University College London Centre for Nephrology, Royal Free Hospital; M. Segelmark, MD, PhD, Department of Nephrology and Department of Medical and Health Sciences, Linköping University
Chocová, Zdeňka
Autor Chocová, Zdeňka From the Department of Nephrology and Department of Medical and Health Sciences, Department of Rheumatology and Department of Clinical and Experimental Medicine, Linköping University, Linköping; Department of Clinical Sciences, Section of Rheumatology, Lund University, Lund; Department of Renal Medicine, Karolinska University Hospital and CLINTEC Karolinska Institute, Stockholm; Department of Nephrology, Lund University, Skåne University Hospital, Lund and Malmö; University College London Centre for Nephrology, Royal Free Hospital; Department of Medicine, Imperial College London, London; Institute of Clinical Sciences, University of Birmingham, Birmingham; Department of Medicine, University of Cambridge, Cambridge, UK; Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Department of Renal Medicine, Tan Tock Seng Hospital, Singapore M. Weiner, MD, Department of Nephrology and Department of Medical and Health Sciences, Linköping University; S.M. Goh, MBBS, University College London Centre for Nephrology, Royal Free Hospital, and Department of Renal Medicine, Tan Tock Seng Hospital; A.J. Mohammad, MD, PhD, Department of Clinical Sciences, Section of Rheumatology, Lund University, and Department of Medicine, University of Cambridge; Z. Hrušková, MD, PhD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; A. Tanna, MD, Department of Medicine, Imperial College London; P. Sharp, PhD, Institute of Clinical Sciences, University of Birmingham; A. Kang, MBBS, Department of Medicine, Imperial College London; A. Bruchfeld, MD, PhD, Department of Renal Medicine, Karolinska University Hospital and CLINTEC Karolinska Institute; D. Selga, MD, PhD, Department of Nephrology, Lund University, Skåne University Hospital; Z. Chocová, MD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; K. Westman, MD, PhD, Department of Nephrology, Lund University, Skåne University Hospital; P. Eriksson, MD, PhD, Department of Rheumatology and Department of Clinical and Experimental Medicine, Linköping University; L. Harper, MBChB, PhD, Institute of Clinical Sciences, University of Birmingham; C.D. Pusey, DSc, FMedSci, Department of Medicine, Imperial College London; V. Tesař, MD, PhD, Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital; A.D. Salama, MBBS, FRCP, PhD, University College London Centre for Nephrology, Royal Free Hospital; M. Segelmark, MD, PhD, Department of Nephrology and Department of Medical and Health Sciences, Linköping University

The Journal of rheumatology. 2020 Apr ; 47 (4) : 580-588. [epub] 20190715

J Rheumatol
ISSN 1499-2752 | 0315-162X
Zdroj

OBJECTIVE: Age is a risk factor for organ damage, adverse events, and mortality in microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA). However, the relationship between treatment and damage, hospitalizations, and causes of death in elderly patients is largely unknown. METHODS: Consecutive patients from Sweden, the United Kingdom, and the Czech Republic diagnosed between 1997 and 2013 were included. Inclusion criteria were a diagnosis of MPA or GPA and age 75 years or more at diagnosis. Treatment with cyclophosphamide (CYC), rituximab (RTX), and corticosteroids the first 3 months was registered. Outcomes up to 2 years from diagnosis included Vasculitis Damage Index (VDI), hospitalization, and cause of death. RESULTS: Treatment data were available for 167 of 202 patients. At 2 years, 4% had no items of damage. There was a positive association between VDI score at 2 years and Birmingham Vasculitis Activity Score at onset, and a negative association with treatment using CYC or RTX. Intravenous methylprednisolone dose was associated with treatment-related damage. During the first year, 69% of patients were readmitted to hospital. Myeloperoxidase-antineutrophil cytoplasmic antibody positivity and lower creatinine levels decreased the odds of readmission. The most common cause of death was infection, and this was associated with cumulative oral prednisolone dose. CONCLUSION: Immunosuppressive treatment with CYC or RTX in elderly patients with MPA and GPA was associated with development of less permanent organ damage and was not associated with hospitalization. However, higher doses of corticosteroids during the first 3 months was associated with treatment-related damage and fatal infections.

Klíčová slova
ANTINEUTROPHIL CYTOPLASMIC ANTIBODY-ASSOCIATED VASCULITIS, GRANULOMATOSIS WITH POLYANGIITIS, HOSPITALIZATION, MICROSCOPIC POLYANGIITIS,
MeSH
granulomatóza s polyangiitidou * komplikace farmakoterapie MeSH
hospitalizace MeSH
lidé MeSH
mikroskopická polyangiitida * farmakoterapie MeSH
peroxidasa MeSH
protilátky proti cytoplazmě neutrofilů MeSH
senioři MeSH
Check Tag
lidé MeSH
senioři MeSH
Publikační typ
časopisecké články MeSH
práce podpořená grantem MeSH
Názvy látek
peroxidasa MeSH
protilátky proti cytoplazmě neutrofilů MeSH

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