Alzheimer's disease (AD) and sporadic Creutzfeldt-Jakob disease (sCJD) are both characterized by extracellular pathologically conformed aggregates of amyloid proteins-amyloid β-protein (Aβ) and prion protein (PrPSc), respectively. To investigate the potential morphological colocalization of Aβ and PrPSc aggregates, we examined the hippocampal regions (archicortex and neocortex) of 20 subjects with confirmed comorbid AD and sCJD using neurohistopathological analyses, immunohistochemical methods, and confocal fluorescent microscopy. Our data showed that extracellular Aβ and PrPSc aggregates tended to be, in most cases, located separately, and "compound" plaques were relatively rare. We observed PrPSc plaque-like structures in the periphery of the non-compact parts of Aβ plaques, as well as in tau protein-positive dystrophic structures. The AD ABC score according to the NIA-Alzheimer's association guidelines, and prion protein subtype with codon 129 methionine-valine (M/V) polymorphisms in sCJD, while representing key characteristics of these diseases, did not correlate with the morphology of the Aβ/PrPSc co-aggregates. However, our data showed that PrPSc aggregation could dominate during co-aggregation with non-compact Aβ in the periphery of Aβ plaques.

• Klíčová slova
• Alzheimer’s disease, Aβ, Creutzfeldt–Jakob disease, colocalization, confocal microscopy, plaques, prion protein, tau protein,
• MeSH
• Alzheimerova nemoc patologie   MeSH
• amyloidní beta-protein genetika   metabolismus   MeSH
• amyloidní plaky patologie   MeSH
• Creutzfeldtova-Jakobova nemoc patologie   MeSH
• extracelulární prostor chemie   MeSH
• jednonukleotidový polymorfismus genetika   MeSH
• kodon genetika   MeSH
• komorbidita MeSH
• lidé středního věku MeSH
• lidé MeSH
• mozek patologie   MeSH
• neurony patologie   MeSH
• pilotní projekty MeSH
• proteinové agregáty * MeSH
• proteiny tau metabolismus   MeSH
• PrPSc proteiny genetika   metabolismus   MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• amyloidní beta-protein MeSH
• kodon MeSH
• proteinové agregáty * MeSH
• proteiny tau MeSH
• PrPSc proteiny MeSH

• MeSH
• DNA primery MeSH
• genotyp MeSH
• ovce MeSH
• polymerázová řetězová reakce veterinární   MeSH
• PrPSc proteiny genetika   MeSH
• rodokmen MeSH
• scrapie epidemiologie   etiologie   genetika   MeSH
• zvířata MeSH
• Check Tag
• mužské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• Geografické názvy
• Slovenská republika epidemiologie   MeSH
• Názvy látek
• DNA primery MeSH
• PrPSc proteiny MeSH