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44 záznamů v PubMed Filtry

Článek

Sabeluzol a flunarizin v pamĕtových procesech: animální studie
[Sabeluzole and flunarizine in memory processes: animal studies]

Ceskoslovenska psychiatrie. 1993 Apr ; 89 (2) : 91-3.

Cesk Psychiatr
ISSN 0069-2336
Zdroj

The memory enhancing properties of sabeluzole nad flunarizine were evaluated in two experimental paradigms in male rats. First, we studied the protective action of both drugs against a chlordiazepoxide-induced impairment of habituation. Sabeluzole (5 or 25 mg/kg) or flunarizine (10 mg/kg) were administered sc 1 hr before and chlordiazepoxide (20 mg/kg) immediately after the acquisition session. In the retention session 72 hr later, chlordiazepoxide treated animals displayed higher locomotor and exploratory activities and this effect was blocked by pretreatment with sabeluzole or flunarizine. The results suggest that both drugs prevented amnesic effect of chlordiazepoxide. The second paradigm was the social memory test in which the time spent in social investigation behaviour toward a familiar or a novel juvenile conspecific was used to measure the duration of the memory that the animal forms of the juvenile. Sabeluzole (25 mg/kg) or flunarizine (3 mg/kg) were injected to the adults immediately after the initial exposure. Reexposure to the same or a novel juvenile was done 2 hr later. In contrast to controls, sabeluzole-treated animals showed a significant reduction in social investigation during reexposure to the same juvenile. Since there was no effect on investigation of a novel juvenile, results suggest that sabeluzole-treated rats are able to remember longer the individual characteristics of juvenile rats obtained through olfactory cues during a short social interaction. The time spent by adults treated with flunarizine in the investigation the same juvenile during reexposure was similar to that observed during the initial exposure. It means that flunarizine was ineffective in enhancing short-term olfactory memory.

MeSH
chlordiazepoxid farmakologie MeSH
flunarizin farmakologie MeSH
habituace (psychofyziologie) účinky léků MeSH
krysa rodu Rattus MeSH
paměť účinky léků MeSH
piperidiny farmakologie MeSH
thiazoly farmakologie MeSH
zvířata MeSH
Check Tag
krysa rodu Rattus MeSH
mužské pohlaví MeSH
zvířata MeSH
Publikační typ
anglický abstrakt MeSH
časopisecké články MeSH
Názvy látek
chlordiazepoxid MeSH
flunarizin MeSH
piperidiny MeSH
sabeluzole MeSH Prohlížeč
thiazoly MeSH

Článek

Sabeluzole improves social recognition and antagonizes chlordiazepoxide's effect on habituation in the rat

Psychopharmacology. 1991 ; 104 (4) : 505-9.

Psychopharmacology (Berl)
ISSN 0033-3158
Zdroj

The memory enhancing properties of sabeluzole were evaluated in two experimental paradigms in rats. First, we determined the protective action of sabeluzole against a chlordiazepoxide-induced impairment of habituation. Sabeluzole (5 or 25 mg/kg, SC) was administered 1 h before and chlordiazepoxide (20 mg/kg, SC) immediately after the acquisition session. In the retention session 72 h later, chlordiazepoxide-treated animals displayed higher locomotor and rearing activities and this effect was blocked by pretreatment with sabeluzole. The results suggest that sabeluzole prevented the amnesic effect of chlordiazepoxide. The second paradigm was a social recognition test in which the behaviour toward a familiar or a novel conspecific was investigated. Time spent in social investigation and time spent sniffing of scent traces left on the floor was estimated during exposure of an adult to a juvenile male rat. Sabeluzole (25 mg/kg, SC) was injected into the adults immediately after the first exposure. Reexposure to the same or a novel juvenile was performed 120 min later. In contrast to control, sabeluzole-treated animals showed a significant reduction in social investigation during the second exposure to the same juvenile. Time spent sniffing the floor was significantly decreased in sabeluzole-treated males. Since there was no effect on investigation of a novel juvenile, results suggest that sabeluzole-treated rats are able to remember longer the individual characteristics of juvenile rat obtained through olfactory cues.

MeSH
chlordiazepoxid antagonisté a inhibitory farmakologie MeSH
habituace (psychofyziologie) účinky léků MeSH
inbrední kmeny potkanů MeSH
kognice účinky léků MeSH
krátkodobá paměť účinky léků MeSH
krysa rodu Rattus MeSH
piperidiny farmakologie MeSH
pohybová aktivita účinky léků MeSH
sociální chování * MeSH
thiazoly farmakologie MeSH
zvířata MeSH
Check Tag
krysa rodu Rattus MeSH
mužské pohlaví MeSH
zvířata MeSH
Publikační typ
časopisecké články MeSH
Názvy látek
chlordiazepoxid MeSH
piperidiny MeSH
sabeluzole MeSH Prohlížeč
thiazoly MeSH

Článek

Effects of the acute and chronic administration of chlordiazepoxide on the development of spontaneous motility in chick embryos

Sedlácek, J
Autor Sedlácek, J Research Laboratory of Psychiatry, Faculty of Medicine, Charles University, Prague

Physiologia Bohemoslovaca. 1989 ; 38 (3) : 241-9.

Physiol Bohemoslov
ISSN 0369-9463
Zdroj

The effects of the acute and chronic administration of chlordiazepoxide on spontaneous motility and on the reactivity of the generator of embryonic motility were studied in chick embryos from the 4th to the 19th day of incubation. 1. The acute administration of chlordiazepoxide (5 mg/kg e.w.) significantly depressed spontaneous motility from the 13th day of incubation. 2. The chronic administration of chlordiazepoxide (12.2 mg/kg e.w./24 h) from the 4th to the 8th, 12th and 16th day of incubation enhanced the reduction of the spontaneous motility of 17-day-old embryos. 3. The chronic administration of chlordiazepoxide significantly modified the activity of both activators (strychnine, metrazol, bicuculline, picrotoxin) and inhibitors (GABA, chlordiazepoxide) of the spontaneous motility of chick embryos.