AIM: To present an outline of acquired atypical forms of ocular toxoplasmosis (OT) in childhood, with reference to the 100th anniversary of the discovery of this etiology by Professor Janků from Czechoslovakia, who was first to describe the clinical congenital picture of OT characterised by macular scar. MATERIAL AND METHODS: Symptoms of intraocular bilateral neuritis appeared in a 6-year-old girl, with visual acuity (VA) bilaterally 0.1. Toxoplasmic etiology was demonstrated in laboratory tests, and the patient was immunocompetent. Following treatment with macrolide antibiotic and parabulbar application of corticosteroid, the condition was normalised stably at VA 1.0 in both eyes. Bilateral retinal vasculitis was determined in an 8-year-old boy, with VA of 0.25 in the right eye and 0.25 in the left, with a medical history of strabismus detected after suffering from varicella. The examination for toxoplasmosis was negative, but pronounced general hypogammaglobulinaemia classes IgG, IgM and IgA was detected. Immunosuppressive and immunomodulatory therapy did not produce the desired effect, and the condition progressed to retinochoroiditis. Due to blindness and dolorous glaucoma, enucleation of the right eye was performed at the age of 15 years. Histologically toxoplasmic cysts with bradyzoites were detected, a subsequent laboratory test demonstrated toxoplasmic etiology upon a background of persistent regressing hypogammaglobulinaemia. General anti-toxoplasma and subsequent immunosuppressive treatment did not produce the desired effect, and at the age of 22 years the patient lost his sight also in the left eye. CONCLUSION: Atypical form of OT intraocular neuritis in an immunocompetent patient had a favourable course, whereas retinal vasculitis with retinochoroiditis in a temporarily immunocompromised patient ended in bilateral blindness.

• Klíčová slova
• Professor Janků, Toxoplasmosis, hypogammaglobulinaemia, intraocular neuritis, retinal vasculitis, retinochoroiditis, varicella,
• MeSH
• agamaglobulinemie * farmakoterapie   MeSH
• antibakteriální látky terapeutické užití   MeSH
• chorioretinitida * farmakoterapie   MeSH
• dítě MeSH
• dospělí MeSH
• hormony kůry nadledvin MeSH
• imunoglobulin A terapeutické užití   MeSH
• imunoglobulin G terapeutické užití   MeSH
• imunoglobulin M terapeutické užití   MeSH
• imunosupresiva terapeutické užití   MeSH
• lidé MeSH
• makrolidy terapeutické užití   MeSH
• mladiství MeSH
• mladý dospělý MeSH
• neuritida * farmakoterapie   MeSH
• oční toxoplazmóza * komplikace   diagnóza   MeSH
• retinální vaskulitida * farmakoterapie   MeSH
• slepota farmakoterapie   MeSH
• Toxoplasma * MeSH
• Check Tag
• dítě MeSH
• dospělí MeSH
• lidé MeSH
• mladiství MeSH
• mladý dospělý MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH
• Názvy látek
• antibakteriální látky MeSH
• hormony kůry nadledvin MeSH
• imunoglobulin A MeSH
• imunoglobulin G MeSH
• imunoglobulin M MeSH
• imunosupresiva MeSH
• makrolidy MeSH

UNLABELLED: Punctate Inner Choroidopathy (PIC) is a rare idiopathic ocular inflammatory disease. It occurs mostly in young, myopic, otherwise healthy women. Symptoms of the disease include acute vision decrease associated with central and paracentral scotoma. In 80% of cases PIC occur bilaterally. We report the case of a woman at the age of twenty-five, who was treated for PIC. Due to the finding of active inflammatory deposit in the retina of the left eye and low visual acuity was recommended corticosteroid therapy with a good therapeutic effect. KEY WORDS: Punctate Inner Choroidopathy (PIC), white dot syndromes.

• MeSH
• chorioretinitida komplikace   diagnóza   farmakoterapie   MeSH
• dospělí MeSH
• fluoresceinová angiografie MeSH
• glukokortikoidy terapeutické užití   MeSH
• lidé MeSH
• skotom diagnóza   farmakoterapie   MeSH
• snížené vidění diagnóza   farmakoterapie   MeSH
• zraková ostrost MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH
• Názvy látek
• glukokortikoidy MeSH

• MeSH
• betamethason aplikace a dávkování   MeSH
• chorioretinitida farmakoterapie   MeSH
• dospělí MeSH
• injekce MeSH
• konjunktiva MeSH
• lidé středního věku MeSH
• lidé MeSH
• recidiva MeSH
• uveitida farmakoterapie   MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• anglický abstrakt MeSH
• časopisecké články MeSH
• Názvy látek
• betamethason MeSH